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Can a simple test predict Alzheimer's years before symptoms start?

NCT ID NCT00869817

Recruiting now Knowledge-focused Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 21, 2026 · Updated 5 times

Summary

This long-term study follows 700 adults who carry a rare genetic mutation that causes early-onset Alzheimer's. Researchers collect blood, spinal fluid, brain scans, and cognitive tests to find biomarkers that signal the disease before memory loss begins. The goal is to improve early detection and help design future prevention trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could identify early warning signs of Alzheimer's in people with genetic mutations, enabling earlier diagnosis and better clinical trial design.
What could go wrong
This is an observational study, not a treatment trial. It may not directly benefit participants, and findings may not apply to the more common, non-genetic forms of Alzheimer's.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Alzheimer disease 3 Alzheimer disease 4 familial Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER'S DISEASE

Contacts and locations

Locations

  • Amsterdam UMC

    RECRUITING

    Amsterdam, 1081HV, Netherlands

  • Asan Medical Center

    RECRUITING

    Seoul, Songpa-Gu, 05505, South Korea

  • Brigham and Women's Hospital

    RECRUITING

    Boston, Massachusetts, 02115, United States

  • Butler Hospital

    RECRUITING

    Providence, Rhode Island, 02906, United States

  • Columbia University

    SUSPENDED

    New York, New York, 10032, United States

  • Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI)

    RECRUITING

    Salta, Salta Province, Argentina

  • Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia" (FLENI) Instituto de Investigaciones Neurológicas Raúl Correa

    RECRUITING

    Buenos Aires, Argentina

  • German Center for Neurodegenerative Diseases (DZNE) Munich, and University Hospital Ludwig-Maximilians-Universitat (LMU) Munich

    RECRUITING

    Munich, D-81377, Germany

  • German Center for Neurodegenerative Diseases (DZNE) Tübingen and Hertie-Institute for Clinical Brain Research, University of Tübingen

    RECRUITING

    Tübingen, D-72076, Germany

  • Grupo Neurociencias de Antioquia

    RECRUITING

    Medellín, Colombia, Colombia

  • Hospital Clinic Barcelona

    SUSPENDED

    Barcelona, Catalonia, 08036, Spain

  • Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo

    RECRUITING

    São Paulo, São Paulo, 05403-900, Brazil

  • Indiana University-Indiana Alzheimer Disease Center

    RECRUITING

    Indianapolis, Indiana, 46202, United States

  • Institute of Neurology, Queen Square

    RECRUITING

    London, WC1N 3BG, United Kingdom

  • Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suarez"

    RECRUITING

    Mexico City, Mexico City, 14269, Mexico

  • Mayo Clinic Jacksonville

    RECRUITING

    Jacksonville, Florida, 32224, United States

  • McGill University Research Centre for Studies in Aging

    NOT_YET_RECRUITING

    Verdun, Quebec, H4H 1R3, Canada

  • Mental Health Research Institute, University of Melbourne

    SUSPENDED

    Melbourne, Victoria, 3130, Australia

  • Neuroscience Research Australia

    RECRUITING

    Sydney, New South Wales, 2031, Australia

  • Niigata University

    RECRUITING

    Niigata, Japan

  • Osaka City University

    SUSPENDED

    Osaka, Japan

  • Sir James McCusker Alzheimer's Disease Research Unit, Edith Cowan University

    RECRUITING

    Perth, Western Australia, 6009, Australia

  • Tokyo University

    RECRUITING

    Tokyo, Japan

  • University of Pittsburgh

    RECRUITING

    Pittsburgh, Pennsylvania, 15260, United States

  • University of Washington

    RECRUITING

    Seattle, Washington, 98195, United States

  • Washington University in St. Louis School of Medicine

    RECRUITING

    St Louis, Missouri, 63108, United States

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