Experimental Alzheimer's vaccine aims to clear brain plaques

NCT ID NCT05462106

Recruiting now Disease control Sponsor: AC Immune SA Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study tests an experimental vaccine called ACI-24.060 in people with early Alzheimer's and non-demented adults with Down syndrome. The vaccine is designed to help the immune system clear amyloid plaques from the brain, which are linked to Alzheimer's. Researchers will check if it is safe and if it can slow memory loss. The trial involves 304 participants and compares the vaccine to a placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ACI-24.060 (an experimental vaccine that targets amyloid plaques in the brain)
What this could lead to: If it works, this vaccine could slow or stop memory decline in early Alzheimer's and in adults with Down syndrome, offering a new way to control the disease.
What could go wrong: This is an early-phase trial (Phase 1/2) with only 304 participants, so it may not prove effective. The vaccine could cause side effects like brain swelling or allergic reactions, and it requires ongoing monitoring.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease brain disorder central nervous system disorder dementia Down syndrome Plaque, Amyloid

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER'S DISEASE AMYLOID PLAQUE BETA-AMYLOID DSAD PRODROMAL ALZHEIMER'S DISEASE

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••
Contact

Email: •••••@•••••

Locations

Barrow Neurological Institute
WITHDRAWN

Phoenix, Arizona, 85013, United States
Cambridge and Peterborough NHS Foundation Trust - Windsor Research Units
ACTIVE_NOT_RECRUITING

Cambridge, United Kingdom
Charter Research, LLC
RECRUITING

Orlando, Florida, 32803, United States
Charter Research, LLC
RECRUITING

The Villages, Florida, 32162, United States
Flourish Research
NOT_YET_RECRUITING

Matthews, North Carolina, 28105, United States
Fundació ACE, Institut Català de Neurociències Aplicades
RECRUITING

Barcelona, Spain
Headlands Horizons LLC
NOT_YET_RECRUITING

Orlando, Florida, 32819, United States
Hospital Clínico San Carlos
RECRUITING

Madrid, Spain
Hospital Universitario Marqués de Valdecilla
ACTIVE_NOT_RECRUITING

Santander, Spain
Hospital Universitario Virgen De Las Nieves
WITHDRAWN

Granada, Spain
Hospital Universitario de la Princesa
ACTIVE_NOT_RECRUITING

Madrid, Spain
Hospital Universitario y Politécnico La Fe
RECRUITING

Valencia, Spain
Hospital de la Santa Creu i Sant Pau
RECRUITING

Barcelona, Spain
Indiana University / IU Health
ACTIVE_NOT_RECRUITING

Indianapolis, Indiana, 46202, United States
K2 Medical Research The Villages LLC
RECRUITING

Lady Lake, Florida, 32159, United States
Liverpool University Hospitals NHS Foundation Trust
RECRUITING

Liverpool, United Kingdom
Massachusetts General Hospital
ACTIVE_NOT_RECRUITING

Boston, Massachusetts, 02114, United States
NeuroClin Limited
NOT_YET_RECRUITING

Warrington, WA3 7PB, United Kingdom
Neurology Clinical, P.C.
RECRUITING

Cordova, Tennessee, 38018, United States
Oxford Health NHS Foundation Trust
RECRUITING

Oxford, United Kingdom
Re:Cognition Health Limited
RECRUITING

London, United Kingdom
South London and Maudsley NHS Foundation Trust of The Maudsley Hospital
RECRUITING

London, United Kingdom
The Washington University
ACTIVE_NOT_RECRUITING

St Louis, Missouri, 63130, United States
UT Health San Antonio
WITHDRAWN

San Antonio, Texas, 78229, United States
University of Kansas Medical Center Research Institute
ACTIVE_NOT_RECRUITING

Fairway, Kansas, 66205-2513, United States
Vanderbilt University Medical Center
ACTIVE_NOT_RECRUITING

Nashville, Tennessee, 37232-2103, United States

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