ALZHEIMER'S DISEASE

This was the first study in people to test the safety and side effects of a new drug called IBC-Ab002 for early Alzheimer's disease. The study involved 40 participants who received either the drug or a placebo through an IV. The main goal was to see how safe the drug was and how …

This study tested whether low daily doses of nilotinib, a drug used for leukemia, could be safe and potentially slow Alzheimer's disease progression. Thirty-seven people with mild to moderate Alzheimer's took either the drug or a placebo pill for six months. Researchers measured …

This was an early safety study of a new drug, MK-1167, for Alzheimer's disease. It involved 28 patients who were already taking a standard Alzheimer's medication (donepezil). The main goals were to check for side effects and see how the drug is processed by the body over 24 hours…

This early-stage study tested the safety and side effects of an experimental drug called BMS-984923 in healthy older adults and people with early Alzheimer's disease. The main goal was to see if the drug was safe at different dose levels and to check if brain scans could detect c…

This study tested whether an investigational drug called lecanemab (BAN2401) could slow the progression of early Alzheimer's disease. It involved 856 people with either mild cognitive impairment or mild dementia due to Alzheimer's. Participants received different doses of the dru…

This study tested an experimental drug called 50561 to see if it could help people with mild to moderate Alzheimer's disease. 68 participants were randomly assigned to receive either the drug or a placebo (a dummy pill) for 24 weeks. Researchers measured changes in memory, thinki…

This study tested a new type of PET scan that uses a special tracer called [18F]APN-1607. The goal was to see if this scan could show different patterns in the brains of healthy people, people with mild memory problems, and people with Alzheimer's dementia. Researchers compared t…

This study aimed to see if measuring certain proteins in the blood could help doctors predict Alzheimer's disease. Researchers followed over 1,000 people with either mild memory problems or early Alzheimer's to see if their blood test results could forecast who would get worse or…

This study tested whether an investigational drug called SAGE-718 could improve cognitive performance, specifically processing speed, in people with early-stage Alzheimer's disease or mild cognitive impairment. 174 participants were randomly assigned to receive either the drug or…

This early-stage study tested an experimental drug called NMRA-323511 to see if it is safe and can help reduce agitation in people with Alzheimer's disease. The trial involved 96 participants, including healthy elderly adults and people with Alzheimer's who experience agitation. …

This study tested whether regular music therapy sessions focused on singing could help improve memory, language, and quality of life for people with Alzheimer's disease or mild cognitive impairment. Over 100 participants were assigned to different schedules of music therapy for a…

This study tested whether a special, tailored lighting treatment could help people with Alzheimer's or dementia sleep better and improve their mood and thinking. Researchers compared the active light treatment to a placebo light for six months in 101 participants. They measured c…

This study used brain imaging scans to understand how age affects the buildup of amyloid protein in the brains of people with Alzheimer's disease and related conditions. Researchers compared younger-onset and older-onset Alzheimer's patients, along with people having specific lan…

This study aimed to understand how Alzheimer's disease affects visual attention and search abilities. Researchers tracked eye movements of 48 participants (including Alzheimer's patients and healthy controls) while they searched for objects on a computer screen and in real-world …

This study aimed to understand if certain proteins in the blood (IGF-I and IGFBP-3) are linked to Alzheimer's disease and memory problems. Researchers compared these protein levels in three groups: people with Alzheimer's, people with mild memory issues, and healthy elderly indiv…

This study tested whether using a virtual reality (VR) headset to deliver light and sound stimulation is safe and practical for people. It involved older adults, some with early Alzheimer's disease and some who were cognitively healthy. The main goal was to see how the brain resp…

This study looked at whether a special brain scan (amyloid PET) helps doctors make better care decisions for people with memory problems or dementia. It followed over 6,000 Medicare patients from diverse backgrounds to see if the scan results changed their treatment plans and hea…

This study followed 404 patients for 10 years after their hip fracture surgery. Researchers wanted to see if signs of early Alzheimer's disease, measured in spinal fluid at the time of surgery, were linked to how long patients lived. The goal is to better understand long-term ris…

This small study tested whether daily text message reminders help people with early Alzheimer's or mild memory problems stick to a morning light therapy routine. Researchers enrolled 20 healthy older adults to see if the reminders improved their compliance. They measured particip…