ALZHEIMER S DISEASE

This study tested a drug called lecanemab (BAN2401) in 856 people with early Alzheimer's disease (mild memory problems or mild dementia). The goal was to see if the drug could slow down worsening of memory and thinking skills compared to a placebo. Participants received different…

This study tested a low dose of nilotinib, a drug normally used for leukemia, in 37 people with mild-to-moderate Alzheimer's. The goal was to see if the drug is safe and whether it can reach the brain and affect proteins linked to Alzheimer's. Participants took the drug or a plac…

This early-stage study tested a new drug called SHR-1707 in 33 people with mild Alzheimer's disease or mild cognitive impairment. The main goal was to see if the drug is safe and how the body processes it. Researchers also looked at whether it could reduce amyloid plaques in the …

This study tested an experimental drug called 50561 in 68 people with mild to moderate Alzheimer's disease. The goal was to see if it could slow down memory and thinking decline compared to a placebo. The trial was double-blind, meaning neither patients nor doctors knew who got t…

This study tested a new imaging agent called [18F]APN-1607 to see if it can help diagnose Alzheimer's disease using PET scans. Researchers compared brain scan patterns in 230 people with Alzheimer's, mild cognitive impairment, and healthy volunteers. The goal was to improve early…

This study looked at whether measuring certain proteins (amyloid peptides) in the blood can help diagnose Alzheimer's disease or predict how fast it will progress. Researchers followed over 1,000 older adults, some with mild cognitive impairment and some with Alzheimer's, to see …

This study tested a dietary supplement made from medium-chain triglycerides (MCTs), a type of fat found in coconut oil, in 43 people with mild-to-moderate Alzheimer's disease or a related language disorder. The main goal was to see if the supplement was safe and tolerable, and to…

This study looked at whether different lengths of light exposure can help people with Alzheimer's disease sleep better and improve their mood and agitation. 135 participants were randomly assigned to receive 2 hours, 4 hours, or all-day morning light. The goal was to find the bes…

This early-stage study tested the safety of a new drug called BMS-984923 in 51 healthy older adults and people with Alzheimer's disease. The goal was to see if the drug is safe and tolerable, and to understand how it works in the body. This is a first step toward possibly easing …

This study tested whether music therapy singing sessions can improve memory and language in people with Alzheimer's disease or mild cognitive impairment. Over 12 months, 100 participants met with a licensed music therapist and were assigned to different music experiences or pleas…

This study tested a new drug called IBC-Ab002 in 40 people with early Alzheimer's disease. The main goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a placebo through an IV, and researchers monitored for side effects an…

This study tested a personalized approach to manage agitation in people with Alzheimer's disease living at home. A nurse worked with doctors and caregivers to create a custom care plan, using video calls and training. The goal was to see if this reduces hospitalizations and helps…

This study tested an experimental drug called SAGE-718 in 174 people with mild cognitive impairment or mild dementia due to Alzheimer's disease. The goal was to see if the drug could improve thinking skills, like processing speed, compared to a placebo. The trial is now complete,…

This early-stage study tested a new drug called MK-1167 in 28 people with Alzheimer's disease who were already taking donepezil. The main goal was to see if MK-1167 is safe and how the body processes it. Researchers measured side effects and drug levels in the blood. This is a fi…

This study looked at whether a specially designed light therapy can improve sleep, thinking, mood, and behavior in people with Alzheimer's disease or mild cognitive impairment. About 100 participants received either the active light or a placebo for 6 months. The goal was to see …

This early-stage study tested an experimental drug called NMRA-323511 in two groups: healthy older adults and people with Alzheimer's disease who experience agitation. The goal was to check the drug's safety and whether it can reduce agitated behaviors. The study involved 96 part…

This early-stage study tested a new drug called MK-8189 (elpipodect) in 29 people with Alzheimer's disease, some of whom also had symptoms like agitation or psychosis. The main goal was to see if the drug is safe and tolerable at different doses. Researchers tracked side effects …

This study looked at over 6,000 Medicare patients with mild cognitive impairment or dementia to see how amyloid PET scans affect their care and health outcomes. Researchers compared results between different racial and ethnic groups to improve precision in diagnosis and treatment…

This study used brain scans to see how age influences the amount of amyloid plaque in people with Alzheimer's disease and two related conditions (posterior cortical atrophy and logopenic progressive aphasia). Researchers compared early-onset and late-onset Alzheimer's to find age…

This study followed 404 older adults for 10 years after hip fracture surgery. Researchers checked if early signs of Alzheimer's in the brain (measured from spinal fluid) were linked to how long patients lived. The goal was to understand if pre-existing brain changes affect long-t…

This study looked at how brain scans and other tests can help find early signs of Alzheimer's disease. Researchers followed 242 healthy volunteers and people with memory problems over time. They used MRI and PET scans to measure brain changes, thinking skills, and daily activitie…

This study looked at whether a quick, painless eye scan can detect early signs of Alzheimer's disease. Researchers measured the thickness of the retina's nerve layer in 200 older adults, some with Alzheimer's and some without. The goal was to see if changes in the eye could serve…

This study looked at whether certain hormone levels in the blood differ between people with Alzheimer's disease, those with mild memory problems, and healthy older adults. Researchers measured IGF-I and IGFBP-3 in 693 participants to see if these levels are linked to thinking and…

This study tested whether a virtual reality headset that plays specific lights and sounds is safe and comfortable for people with early Alzheimer's and for healthy older adults. 27 volunteers tried the headset while researchers measured brain activity and asked about side effects…

This study looked at how people with Alzheimer's disease search for objects in realistic scenes and real-life settings. Researchers tracked eye movements to understand which parts of attention and memory are impaired. The goal was to link these visual difficulties to problems wit…

This study looked at whether text message reminders help older adults follow a daily morning light routine designed to reset their internal body clock. Twenty healthy adults over age 55 took part. Researchers measured light exposure and sleep patterns to see if reminders improved…