New antibody shows promise in slowing Alzheimer's decline

NCT ID NCT01767311

Completed Disease control Sponsor: Eisai Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested an experimental drug called lecanemab (BAN2401) in 856 people with early Alzheimer's disease, including those with mild cognitive impairment or mild dementia. Participants received different doses of the drug or a placebo every 2 or 4 weeks for 18 months. The goal was to see if lecanemab could slow cognitive decline and reduce amyloid plaques in the brain. Results suggested the drug may help slow disease progression, but side effects like brain swelling were observed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lecanemab (also known as BAN2401), an antibody given by IV infusion
What this could lead to: If it works, this could lead to a treatment that slows memory loss and cognitive decline in people with early Alzheimer's disease.
What could go wrong: This is a Phase 2 trial, so results are still early. The drug may not work for everyone, and side effects like brain swelling or bleeding can occur.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER'S DISEASE

Contacts and locations

Locations

Eisai Trial Site #1

Otake-shi, Hiroshima, Japan
Eisai Trial Site #1

Himeji-shi, Hyōgo, Japan
Eisai Trial Site #1

Kobe, Hyōgo, Japan
Eisai Trial Site #1

Nishinomiya-shi, Hyōgo, Japan
Eisai Trial Site #1

Kyoto, Kyoto, Japan
Eisai Trial Site #1

Kurashiki-shi, Okayama-ken, Japan
Eisai Trial Site #1

Osaka, Osaka, Japan
Eisai Trial Site #1

Saitama-shi, Saitama, Japan
Eisai Trial Site #1

Itabashi-ku, Tokyo-To, Japan
Eisai Trial Site #1

Shinjuku-ku, Tokyo-To, Japan
Eisai Trial Site #2

Himeji-shi, Hyōgo, Japan
Eisai Trial Site #2

Shinjuku-ku, Tokyo-To, Japan
Eisai Trial Site #3

Himeji-shi, Hyōgo, Japan
Facility #1

Birmingham, Alabama, 35294, United States
Facility #1

Phoenix, Arizona, 85004, United States
Facility #1

Tucson, Arizona, 85724, United States
Facility #1

Carson, California, 90746, United States
Facility #1

Lomita, California, 90717, United States
Facility #1

Long Beach, California, 90806, United States
Facility #1

Los Alamitos, California, 90720, United States
Facility #1

Los Angeles, California, 90024, United States
Facility #1

Orange, California, United States
Facility #1

Oxnard, California, 93030, United States
Facility #1

San Diego, California, 92123, United States
Facility #1

Denver, Colorado, 80239-3133, United States
Facility #1

New Haven, Connecticut, 06510, United States
Facility #1

Atlantis, Florida, 33462, United States
Facility #1

Boca Raton, Florida, 33431, United States
Facility #1

Bradenton, Florida, 34205, United States
Facility #1

Deerfield Beach, Florida, 33064, United States
Facility #1

Delray Beach, Florida, 33445, United States
Facility #1

Fort Myers, Florida, 33912, United States
Facility #1

Hallandale, Florida, 33009, United States
Facility #1

Hialeah, Florida, 33016, United States
Facility #1

Lake Worth, Florida, 33449, United States
Facility #1

Leesburg, Florida, 34748, United States
Facility #1

Miami, Florida, 33133, United States
Facility #1

Miami Springs, Florida, 33166, United States
Facility #1

Naples, Florida, 34102, United States
Facility #1

Ocala, Florida, 34471, United States
Facility #1

Orlando, Florida, 32806, United States
Facility #1

Palm Beach Gardens, Florida, 33410, United States
Facility #1

St. Petersburg, Florida, 33713, United States
Facility #1

Sunrise, Florida, 33351, United States
Facility #1

Tampa, Florida, 33613, United States
Facility #1

The Villages, Florida, United States
Facility #1

Atlanta, Georgia, 30329, United States
Facility #1

Columbus, Georgia, 31909, United States
Facility #1

Decatur, Georgia, 30033, United States
Facility #1

Chicago, Illinois, 60640, United States
Facility #1

Elk Grove Village, Illinois, 60007, United States
Facility #1

Elkhart, Indiana, 46514, United States
Facility #1

Indianapolis, Indiana, 46202, United States
Facility #1

Wichita, Kansas, 67214, United States
Facility #1

Lexington, Kentucky, 40504, United States
Facility #1

Boston, Massachusetts, 02115, United States
Facility #1

Burlington, Massachusetts, 01805, United States
Facility #1

Newton, Massachusetts, 02459, United States
Facility #1

Ann Arbor, Michigan, 48105-2945, United States
Facility #1

East Lansing, Michigan, United States
Facility #1

Farmington Hills, Michigan, 48334, United States
Facility #1

Lansing, Michigan, 48824, United States
Facility #1

West Bloomfield, Michigan, 48322, United States
Facility #1

St Louis, Missouri, 63118, United States
Facility #1

Eatontown, New Jersey, 07724, United States
Facility #1

Toms River, New Jersey, 08755, United States
Facility #1

Albany, New York, 12206, United States
Facility #1

Amherst, New York, 14226, United States
Facility #1

Latham, New York, 12110, United States
Facility #1

New York, New York, 10016, United States
Facility #1

Rochester, New York, 14620, United States
Facility #1

Charlotte, North Carolina, 28211, United States
Facility #1

Centerville, Ohio, 45459, United States
Facility #1

Oklahoma City, Oklahoma, 73112, United States
Facility #1

Portland, Oregon, 97239, United States
Facility #1

Abington, Pennsylvania, 19001, United States
Facility #1

Jenkintown, Pennsylvania, 19046, United States
Facility #1

East Providence, Rhode Island, 02914, United States
Facility #1

Knoxville, Tennessee, 37920, United States
Facility #1

Austin, Texas, 78757, United States
Facility #1

Dallas, Texas, 75214, United States
Facility #1

Houston, Texas, 77074, United States
Facility #1

San Antonio, Texas, 78229, United States
Facility #1

Bennington, Vermont, 05201, United States
Facility #1

Richmond, Virginia, 23294, United States
Facility #1

Milwaukee, Wisconsin, 53226, United States
Facility #1

Kentville, Nova Scotia, Canada
Facility #1

Kingston, Ontario, Canada
Facility #1

Ottawa, Ontario, Canada
Facility #1

Peterborough, Ontario, Canada
Facility #1

Toronto, Ontario, Canada
Facility #1

Greenfield Park, Quebec, Canada
Facility #1

Montreal, Quebec, Canada
Facility #1

Verdun, Quebec, Canada
Facility #1

Québec, Canada
Facility #1

Strasbourg, Bas Rhin, France
Facility #1

Toulouse, Haute Garonne, France
Facility #1

Paris, Paris, France
Facility #1

Bron, France
Facility #1

Paris, France
Facility #1

Rennes, France
Facility #1

Villeurbanne, France
Facility #1

Gunzburg, Baden-Wurttemberg, Germany
Facility #1

Karlstadt am Main, Bavaria, Germany
Facility #1

Hanover, Lower Saxony, Germany
Facility #1

Mittweida, Saxony, Germany
Facility #1

Hoppegarten, State of Berlin, Germany
Facility #1

Berlin, Germany
Facility #1

Günzburg, Germany
Facility #1

Hamburg, Germany
Facility #1

Heidelberg, Germany
Facility #1

Leipzig, Germany
Facility #1

Mannheim, Germany
Facility #1

München, Germany
Facility #1

Tübingen, Germany
Facility #1

Brescia, Italy
Facility #1

Genova, Italy
Facility #1

Milan, Italy
Facility #1

Parma, Italy
Facility #1

Perugia, Italy
Facility #1

Pisa, Italy
Facility #1

Roma, Italy
Facility #1

Amsterdam, Netherlands
Facility #1

Seongnam-si, Gyeonggi-do, South Korea
Facility #1

Pusan, Gyeongsangnam-do, South Korea
Facility #1

Sant Cugat Del Vallés, Barcelona, Spain
Facility #1

Donostia / San Sebastian, Guipuzcoa, Spain
Facility #1

Barakaldo, Vizcaya, Spain
Facility #1

Alicante, Spain
Facility #1

Barcelona, Spain
Facility #1

Madrid, Spain
Facility #1

Seville, Spain
Facility #1

Malmö, Sweden
Facility #1

Mölndal, Sweden
Facility #1

Stockholm, Sweden
Facility #1

Uppsala, Sweden
Facility #1

London, Greater London, United Kingdom
Facility #1

Isleworth, Middlesex, United Kingdom
Facility #1

Glasgow, Renfrewshire, United Kingdom
Facility #1

Bath, United Kingdom
Facility #1

Swindon, United Kingdom
Facility #2

Los Angeles, California, 90024, United States
Facility #2

New Haven, Connecticut, 06510, United States
Facility #2

Boca Raton, Florida, 33486, United States
Facility #2

Leesburg, Florida, 34749, United States
Facility #2

Miami, Florida, 33137, United States
Facility #2

Tampa, Florida, 33613, United States
Facility #2

Atlanta, Georgia, 30308, United States
Facility #2

Boston, Massachusetts, 02118, United States
Facility #2

New York, New York, 10021, United States
Facility #2

Rochester, New York, 14623, United States
Facility #2

Oklahoma City, Oklahoma, 73116, United States
Facility #2

Portland, Oregon, 97210, United States
Facility #2

Dallas, Texas, United States
Facility #2

San Antonio, Texas, 78229, United States
Facility #2

London, Ontario, Canada
Facility #2

Berlin, Germany
Facility #2

Roma, Italy
Facility #2

Seoul, South Korea
Facility #2

Madrid, Spain
Facility #2

London, United Kingdom
Facility #3

Los Angeles, California, 90024, United States
Facility #3

Miami, Florida, 33145, United States
Facility #3

Tampa, Florida, 33609, United States
Facility #3

San Antonio, Texas, 78229, United States
Facility #3

Berlin, Germany
Facility #3

Roma, Italy
Facility #3

Seoul, South Korea
Facility #4

Seoul, South Korea

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