New antibody shows promise in slowing Alzheimer's decline

NCT ID NCT01767311

Completed Disease control Sponsor: Eisai Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested an experimental drug called lecanemab (BAN2401) in 856 people with early Alzheimer's disease, including those with mild cognitive impairment or mild dementia. Participants received different doses of the drug or a placebo every 2 or 4 weeks for 18 months. The goal was to see if lecanemab could slow cognitive decline and reduce amyloid plaques in the brain. Results suggested the drug may help slow disease progression, but side effects like brain swelling were observed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Lecanemab (also known as BAN2401), an antibody given by IV infusion

What this could lead to

If it works, this could lead to a treatment that slows memory loss and cognitive decline in people with early Alzheimer's disease.

What could go wrong

This is a Phase 2 trial, so results are still early. The drug may not work for everyone, and side effects like brain swelling or bleeding can occur.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER S DISEASE

Contacts and locations

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Locations

Eisai Trial Site #1

Otake-shi, Hiroshima, Japan
Eisai Trial Site #1

Himeji-shi, Hyōgo, Japan
Eisai Trial Site #1

Kobe, Hyōgo, Japan
Eisai Trial Site #1

Nishinomiya-shi, Hyōgo, Japan
Eisai Trial Site #1

Kyoto, Kyoto, Japan
Eisai Trial Site #1

Kurashiki-shi, Okayama-ken, Japan
Eisai Trial Site #1

Osaka, Osaka, Japan
Eisai Trial Site #1

Saitama-shi, Saitama, Japan
Eisai Trial Site #1

Itabashi-ku, Tokyo-To, Japan
Eisai Trial Site #1

Shinjuku-ku, Tokyo-To, Japan
Eisai Trial Site #2

Himeji-shi, Hyōgo, Japan
Eisai Trial Site #2

Shinjuku-ku, Tokyo-To, Japan
Eisai Trial Site #3

Himeji-shi, Hyōgo, Japan
Facility #1

Birmingham, Alabama, 35294, United States
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Phoenix, Arizona, 85004, United States
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Tucson, Arizona, 85724, United States
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Carson, California, 90746, United States
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Lomita, California, 90717, United States
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Long Beach, California, 90806, United States
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Los Alamitos, California, 90720, United States
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Los Angeles, California, 90024, United States
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Orange, California, United States
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Oxnard, California, 93030, United States
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San Diego, California, 92123, United States
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Denver, Colorado, 80239-3133, United States
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New Haven, Connecticut, 06510, United States
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Atlantis, Florida, 33462, United States
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Boca Raton, Florida, 33431, United States
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Bradenton, Florida, 34205, United States
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Deerfield Beach, Florida, 33064, United States
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Delray Beach, Florida, 33445, United States
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Fort Myers, Florida, 33912, United States
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Hallandale, Florida, 33009, United States
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Hialeah, Florida, 33016, United States
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Lake Worth, Florida, 33449, United States
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Leesburg, Florida, 34748, United States
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Miami, Florida, 33133, United States
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Miami Springs, Florida, 33166, United States
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Naples, Florida, 34102, United States
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Ocala, Florida, 34471, United States
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Orlando, Florida, 32806, United States
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Palm Beach Gardens, Florida, 33410, United States
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St. Petersburg, Florida, 33713, United States
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Sunrise, Florida, 33351, United States
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Tampa, Florida, 33613, United States
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The Villages, Florida, United States
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Atlanta, Georgia, 30329, United States
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Columbus, Georgia, 31909, United States
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Decatur, Georgia, 30033, United States
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Chicago, Illinois, 60640, United States
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Elk Grove Village, Illinois, 60007, United States
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Elkhart, Indiana, 46514, United States
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Indianapolis, Indiana, 46202, United States
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Wichita, Kansas, 67214, United States
Facility #1

Lexington, Kentucky, 40504, United States
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Boston, Massachusetts, 02115, United States
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Burlington, Massachusetts, 01805, United States
Facility #1

Newton, Massachusetts, 02459, United States
Facility #1

Ann Arbor, Michigan, 48105-2945, United States
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East Lansing, Michigan, United States
Facility #1

Farmington Hills, Michigan, 48334, United States
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Lansing, Michigan, 48824, United States
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West Bloomfield, Michigan, 48322, United States
Facility #1

St Louis, Missouri, 63118, United States
Facility #1

Eatontown, New Jersey, 07724, United States
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Toms River, New Jersey, 08755, United States
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Albany, New York, 12206, United States
Facility #1

Amherst, New York, 14226, United States
Facility #1

Latham, New York, 12110, United States
Facility #1

New York, New York, 10016, United States
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Rochester, New York, 14620, United States
Facility #1

Charlotte, North Carolina, 28211, United States
Facility #1

Centerville, Ohio, 45459, United States
Facility #1

Oklahoma City, Oklahoma, 73112, United States
Facility #1

Portland, Oregon, 97239, United States
Facility #1

Abington, Pennsylvania, 19001, United States
Facility #1

Jenkintown, Pennsylvania, 19046, United States
Facility #1

East Providence, Rhode Island, 02914, United States
Facility #1

Knoxville, Tennessee, 37920, United States
Facility #1

Austin, Texas, 78757, United States
Facility #1

Dallas, Texas, 75214, United States
Facility #1

Houston, Texas, 77074, United States
Facility #1

San Antonio, Texas, 78229, United States
Facility #1

Bennington, Vermont, 05201, United States
Facility #1

Richmond, Virginia, 23294, United States
Facility #1

Milwaukee, Wisconsin, 53226, United States
Facility #1

Kentville, Nova Scotia, Canada
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Kingston, Ontario, Canada
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Ottawa, Ontario, Canada
Facility #1

Peterborough, Ontario, Canada
Facility #1

Toronto, Ontario, Canada
Facility #1

Greenfield Park, Quebec, Canada
Facility #1

Montreal, Quebec, Canada
Facility #1

Verdun, Quebec, Canada
Facility #1

Québec, Canada
Facility #1

Strasbourg, Bas Rhin, France
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Toulouse, Haute Garonne, France
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Paris, Paris, France
Facility #1

Bron, France
Facility #1

Paris, France
Facility #1

Rennes, France
Facility #1

Villeurbanne, France
Facility #1

Gunzburg, Baden-Wurttemberg, Germany
Facility #1

Karlstadt am Main, Bavaria, Germany
Facility #1

Hanover, Lower Saxony, Germany
Facility #1

Mittweida, Saxony, Germany
Facility #1

Hoppegarten, State of Berlin, Germany
Facility #1

Berlin, Germany
Facility #1

Günzburg, Germany
Facility #1

Hamburg, Germany
Facility #1

Heidelberg, Germany
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Leipzig, Germany
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Mannheim, Germany
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München, Germany
Facility #1

Tübingen, Germany
Facility #1

Brescia, Italy
Facility #1

Genova, Italy
Facility #1

Milan, Italy
Facility #1

Parma, Italy
Facility #1

Perugia, Italy
Facility #1

Pisa, Italy
Facility #1

Roma, Italy
Facility #1

Amsterdam, Netherlands
Facility #1

Seongnam-si, Gyeonggi-do, South Korea
Facility #1

Pusan, Gyeongsangnam-do, South Korea
Facility #1

Sant Cugat Del Vallés, Barcelona, Spain
Facility #1

Donostia / San Sebastian, Guipuzcoa, Spain
Facility #1

Barakaldo, Vizcaya, Spain
Facility #1

Alicante, Spain
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Barcelona, Spain
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Madrid, Spain
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Seville, Spain
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Malmö, Sweden
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Mölndal, Sweden
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Stockholm, Sweden
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Uppsala, Sweden
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London, Greater London, United Kingdom
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Isleworth, Middlesex, United Kingdom
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Glasgow, Renfrewshire, United Kingdom
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Bath, United Kingdom
Facility #1

Swindon, United Kingdom
Facility #2

Los Angeles, California, 90024, United States
Facility #2

New Haven, Connecticut, 06510, United States
Facility #2

Boca Raton, Florida, 33486, United States
Facility #2

Leesburg, Florida, 34749, United States
Facility #2

Miami, Florida, 33137, United States
Facility #2

Tampa, Florida, 33613, United States
Facility #2

Atlanta, Georgia, 30308, United States
Facility #2

Boston, Massachusetts, 02118, United States
Facility #2

New York, New York, 10021, United States
Facility #2

Rochester, New York, 14623, United States
Facility #2

Oklahoma City, Oklahoma, 73116, United States
Facility #2

Portland, Oregon, 97210, United States
Facility #2

Dallas, Texas, United States
Facility #2

San Antonio, Texas, 78229, United States
Facility #2

London, Ontario, Canada
Facility #2

Berlin, Germany
Facility #2

Roma, Italy
Facility #2

Seoul, South Korea
Facility #2

Madrid, Spain
Facility #2

London, United Kingdom
Facility #3

Los Angeles, California, 90024, United States
Facility #3

Miami, Florida, 33145, United States
Facility #3

Tampa, Florida, 33609, United States
Facility #3

San Antonio, Texas, 78229, United States
Facility #3

Berlin, Germany
Facility #3

Roma, Italy
Facility #3

Seoul, South Korea
Facility #4

Seoul, South Korea