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Brain training vs. Alzheimer's: does it work?

NCT ID NCT00646269

Disease control Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested three non-drug approaches—cognitive training, reminiscence therapy, and a personalized program—in 640 people with mild-to-moderate Alzheimer's. The goal was to see if these therapies could delay progression to severe dementia. Participants were followed for changes in thinking, daily function, mood, and quality of life.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

640 people

The number who actually took part.

Start date

Mar 2008

Finished

Dec 2012

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients in the mild to moderate stages of Alzheimer's Disease : MMSE score between 16 and 26 ; and stages 3 to 5 of the Global Deterioration Scale * Patients over 50 years of age * Patients with social security affiliation Exclusion Criteria: * Patients suffering other type of dementia * Institutionalized patients * Patients with psychiatric disorder * Patients with severe pathology in the terminal stages * Patients receiving non pharmacological therapies other than that proposed in the study * Enrollment in a pharmacological trial in the first 6 months

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Conditions

The condition(s) this trial relates to.

Alzheimer disease dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer's disease

Contacts and locations

Locations

  • Association AA83 Alzheimer Aidants Var Etablissement " Les pensées "

    La Seyne-sur-Mer, 83500, France

  • Bagatelle

    Talence, 33401, France

  • CH Agen

    Agen, 47923, France

  • CHI Poissy-saint-germain-en-laye

    Poissy, 78300, France

  • CHIC Marmande - Tonneins

    Tonneins, 47400, France

  • CHRU de Saint-Etienne

    Saint-Etienne, 42055, France

  • CHU Amiens Nord

    Amiens, 80054, France

  • CHU Côte de Nacre

    Caen, 14033, France

  • CHU Limoges

    Limoges, 87042, France

  • CHU Purpan-Casselardit

    Toulouse, 31300, France

  • CHU de Rennes

    Rennes, 35000, France

  • CMRR & Neuropsychologie, Pavillon de Neurologie, CHU de Grenoble

    Grenoble, 38043, France

  • Centre Antonin Balmes

    Montpellier, 34295, France

  • Centre Hospitalier Bretagne Sud

    Lorient, 56322, France

  • Centre Hospitalier La Rochelle

    La Rochelle, 17000, France

  • Centre Hospitalier de Libourne

    Libourne, 33505, France

  • Centre Hospitalier des Pyrénées

    Pau, 64000, France

  • Centre Mémoire de Ressources et de Recherches de Bordeaux, CHU de Bordeaux

    Bordeaux, 33076, France

  • Centre Mémoire, Hôpital Pasteur,

    Nice, 06002, France

  • Centre de Gériatrie

    Dax, 40107, France

  • Centre hospitalier Ariège Couserans

    Saint-Girons, 09201, France

  • Centre pour Personnes Agées

    Colmar, 68020, France

  • Clinique Neurologique, CHU Nord

    Nantes, 44093, France

  • Groupe Hospitalier Saint-Augustin

    Malestroit, 56140, France

  • Hôpital Broca

    Paris, 75013, France

  • Hôpital Dupuytren

    Draveil, 92210, France

  • Hôpital Gui de Chauliac

    Montpellier, 34295, France

  • Hôpital Pellegrin

    Bordeaux, 33076, France

  • Hôpital Privé Gériatrique Les Magnolias

    Longjumeau, 91161, France

  • Hôpital Sainte-Marguerite

    Marseille, 13009, France

  • Hôpital Xavier-Arnozan

    Pessac, 33604, France

  • Hôpital de Jour Gériatrique

    Pau, 64000, France

  • Hôpital de Jour Gériatrique

    Saint-Raphaël, 83700, France

  • Hôpital de Jour gériatrique

    Poitiers, 86021, France

  • Hôpital de la Salpétrière,

    Paris, 75013, France

  • Hôpital des Charpennes

    Villeurbanne, 69100, France

  • Hôpitaux universitaires de Strasbourg

    Strasbourg, 67091, France

  • Les Fontaines de Monjous

    Gradignan, 33170, France

  • Pôle de Gérontologie CHICAS

    Gap, 05007, France

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