New PET tracer aims to spot Alzheimer's tau tangles more clearly

NCT ID NCT07306598

Recruiting now Diagnosis Sponsor: Tianjin Medical University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new radioactive tracer called [18F]NIDF that binds to tau tangles in the brain, which are linked to Alzheimer's and other neurodegenerative diseases. Researchers will give the tracer to 20 healthy volunteers and patients, then use PET scans to see how well it highlights tau buildup. The main goals are to check safety and see if the tracer can improve diagnosis compared to existing methods.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: [18F]NIDF (a radioactive tracer for PET imaging)
What this could lead to: If successful, this could lead to a more accurate way to diagnose Alzheimer's and other tau-related brain diseases using PET scans.
What could go wrong: This is a very early, small study (20 participants) focused on safety and imaging quality, not treatment. The tracer may not prove better than existing methods.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease neurodegenerative disease tauopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER'S DISEASE NEURODEGENERATIVE DISEASE TAUOPATHIES

Contacts and locations

Locations

The First Affiliated Hospital of University of Science and Technology of China
RECRUITING

Hefei, Anhui, 230000, China
Tianjin Medical University General Hospital
RECRUITING

Tianjin, Tianjin Municipality, 350005, China

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