Could a radioactive tracer reveal hidden brain inflammation in Alzheimer's?

NCT ID NCT06129838

Recruiting now Knowledge-focused Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new radioactive tracer called [11C]-CS1P1 to see if it can detect inflammation in the brains of people with Alzheimer's disease. Researchers will compare brain scans from 80 older adults—some healthy and some with memory problems—to see if the tracer lights up more in Alzheimer's patients. The goal is to better understand how inflammation relates to Alzheimer's and potentially improve diagnosis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: [11C]-CS1P1 (a radioactive tracer for PET scans)
What this could lead to: If successful, this could lead to a new way to see brain inflammation in Alzheimer's, helping doctors diagnose and track the disease more accurately.
What could go wrong: This is an early imaging study with only 80 participants, so it may not confirm whether the tracer reliably distinguishes Alzheimer's from normal aging. The tracer is investigational and not yet approved for routine use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE

Contacts and locations

Locations

Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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