New pill aims to slow Alzheimer's before symptoms worsen

NCT ID NCT06402838

Ongoing Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 2 times

Summary

This study tests an experimental daily pill (RO7269162) in 256 people who either have brain plaques but no symptoms, or have mild memory problems due to Alzheimer's. Participants take the pill or a placebo for about 1.5 years, with regular check-ups to monitor safety and brain changes via PET scans and spinal fluid tests. The goal is to see if the drug can reduce harmful plaques and other disease markers.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER'S DISEASE

Contacts and locations

Locations

Aarhus Universitetshospital Skejby

Aarhus N, 8200, Denmark
Ambulates Gesundheitszentrum der Charité GmbH

Berlin, 12200, Germany
CHU de Rouen Hopital

Rouen, 76031, France
Centro de Investigación Clínica UC-CICUC

Santiago, 8330034, Chile
Charing Cross Hospital

London, W6 8RF, United Kingdom
Complejo Asistencial Universitario de Salamanca

Salamaca, Salamanca, 37007, Spain
ECRC Experimental and Clinical Research Center, Charité Campus Berlin Buch, Memory Clinic

Berlin, 13125, Germany
ETG Neuroscience Sp. z o.o.

Warsaw, 02-777, Poland
EUROMEDIS Sp z o o

Szczecin, 70-111, Poland
Fondazione Istituto Neurologico Mondino IRCCS

Pavia, Lombardy, 27100, Italy
Fundacio ACE

Barcelona, 08028, Spain
Gerontopole

Toulouse, 31059, France
Groupement Hospitalier Est - Hôpital Neurologique

Bron, 69677, France
Hop Guillaume Et Rene Laennec

Saint-Herblain, 44800, France
Hopital B Roger Salengro

Lille, 59037, France
Hospital Clinico Univ de Chile

Santiago, Chile
Hospital General De Catalunya

Sant Cugat del Vallès, Barcelona, 8195, Spain
Hospital Quiron de Madrid

Pozuelo de Alarcón, Madrid, 28223, Spain
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Dr. Peset

Valencia, 46017, Spain
Hospital Universitario Reina Sofia

Córdoba, 14004, Spain
Hospital Universitario la Fe

Valencia, 46026, Spain
Hospital Victoria Eugenia

Seville, 41009, Spain
Hospital Virgen del Rocío

Seville, 41013, Spain
Hôpital Lariboisière

Paris, 75010, France
Hôpital Robertsau

Strasbourg, 67000, France
Hôpital de la Timone

Marseille, 13385, France
IRCCS Ospedale San Raffaele

Milan, Lombardy, 20132, Italy
Inha University Hospital

Incheon, 22332, South Korea
Manchester Mental Health and Social Care Trust

Manchester, M13 9WL, United Kingdom
NEURO-CARE Sp. z o.o. Sp. Komandytowa

Katowice, 40-749, Poland
NZOZ Vitamed

Bydgoszcz, 85-079, Poland
NZOZ WCA

Wroc?aw, 53-659, Poland
Ospedale Cardinale Panico

Tricase (LE), Apulia, 73039, Italy
Podlaskie Centrum Psychogeriatrii

Bia?ystok, 15-756, Poland
Policlínica Guipuzcoa

Donostia / San Sebastian, Guipuzcoa, 20014, Spain
ProNeuro Centrum Medyczne

?ory, 44-240, Poland
RE:Cognition Health

London, W1G 8TA, United Kingdom
Rigshospitalet, Hukommelsesklinikken

Koebenhavn Oe, 2100, Denmark
Scottish Brain Sciences

Edinburgh, EH12 9DQ, United Kingdom
Senior Sp. Z O.O. Poradnia Psychogeriatryczna

Sopot, 81-855, Poland
Southampton General Hospital

Southampton, SO16 6YD, United Kingdom
Surrey and Borders NHS Foundation Trust

Chertsey, KT16 9AU, United Kingdom
Szpital Uniwersytecki w Krakowie

Krakow, 30-688, Poland
TUM Klinikum rechts der Isar;Ambulanz für neurokognitive Erkrankungen

München, 81675, Germany
Umberto I Policlinico di Roma-Università di Roma La Sapienza

Rome, Lazio, 00185, Italy

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