Brain scans track Alzheimer's clues over decades
NCT ID NCT00950430
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study uses special brain scans (PET imaging) to measure amyloid buildup—a protein linked to Alzheimer's—in healthy older adults, people with mild memory problems, and those with dementia. Participants receive scans every 2-3 years for up to 20 years to see how amyloid changes over time and relates to memory decline. The goal is to improve early diagnosis and understanding of Alzheimer's and related dementias.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Pittsburgh Compound B (C-11 PiB) and F-18 FDG
- What this could lead to
- If successful, this could lead to better early detection and tracking of Alzheimer's and other dementias, helping doctors diagnose and monitor these diseases more accurately.
- What could go wrong
- This is an observational imaging study, not a treatment trial. It may not directly improve patient outcomes, and results may take many years to yield practical benefits.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ALZHEIMER'S DISEASE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Mayo Clinic
Rochester, Minnesota, 55905, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could your brain help unlock Alzheimer's secrets?
- Can a nudge in your chart unlock Life-Saving genetic clues?
- Can a gene therapy clear the toxic tau tangle in Alzheimer's?
- Can a new drug tame Alzheimer's? early trial aims to find out
- Could a brain disease change behavior years before diagnosis?
- Skin, speech, and brain scans may unmask hidden neurodegeneration