New dosing strategy aims to make Alzheimer's drug safer and more effective
NCT ID NCT05738486
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests different dosing schedules of the drug donanemab in about 1,175 people with early symptomatic Alzheimer's disease. The goal is to find a regimen that lowers brain amyloid plaques while reducing the risk of a side effect called ARIA-E (brain swelling or small bleeds). Participants will receive donanemab infusions and be monitored for up to 91 weeks. The study also looks at patient traits that might predict who is more likely to develop ARIA.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Adams Clinical
Watertown, Massachusetts, 02472, United States
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Alzheimer's Research and Treatment Center
Stuart, Florida, 34997, United States
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Alzheimer's Research and Treatment Center
Wellington, Florida, 33414, United States
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Brain Matters Research
Delray Beach, Florida, 33445, United States
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Butler Hospital
Providence, Rhode Island, 02906, United States
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California Neuroscience Research Medical Group, Inc.
Sherman Oaks, California, 91403, United States
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CenExel iResearch, LLC
Decatur, Georgia, 30030, United States
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CenExel iResearch, LLC
Savannah, Georgia, 31405, United States
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Center for Advanced Research & Education
Gainesville, Georgia, 30501, United States
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Charter Research - Lady Lake
The Villages, Florida, 32162, United States
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Charter Research - Winter Park
Orlando, Florida, 32803, United States
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ClinCloud - Maitland
Maitland, Florida, 32751, United States
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ClinCloud - Viera
Melbourne, Florida, 32940, United States
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Columbus Memory Center, LLC
Columbus, Georgia, 31909, United States
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Conquest Research
Winter Park, Florida, 32789, United States
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Excel Medical Clinical Trials
Boca Raton, Florida, 33434, United States
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Finlay Medical Research
Greenacres City, Florida, 33467, United States
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Gadolin Research
Beaumont, Texas, 77702, United States
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Healthy Brain Clinic
Long Beach, California, 90804, United States
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Infinity Clinical Research, LLC
Hollywood, Florida, 33024, United States
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Irvine Clinical Research
Irvine, California, 92614, United States
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JEM Research Institute
Atlantis, Florida, 33462, United States
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Jacksonville Center for Clinical Research
Jacksonville, Florida, 32216, United States
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K2 Medical Research
Clermont, Florida, 34711, United States
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K2 Medical Research
Maitland, Florida, 32751, United States
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K2 Medical Research - Tampa
Tampa, Florida, 33607, United States
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K2 Summit Research
The Villages, Florida, 32159, United States
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Kerwin Medical Center
Dallas, Texas, 75231, United States
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MD First Research - Chandler
Chandler, Arizona, 85286, United States
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MedVadis Research Corporation
Waltham, Massachusetts, 02451, United States
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Neurology Clinic, P.C.
Cordova, Tennessee, 38018, United States
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Neuropsychiatric Research Center of Southwest Florida
Fort Myers, Florida, 33912, United States
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Northwest Clinical Research Center
Bellevue, Washington, 98007, United States
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Palm Beach Neurology
West Palm Beach, Florida, 33407, United States
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Progressive Medical Research
Port Orange, Florida, 32127, United States
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QUEST Research Institute
Farmington Hills, Michigan, 48334, United States
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Re:Cognition Health
Fairfax, Virginia, 22031, United States
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Re:Cognition Health - Birmingham
Birmingham, B16 8LT, United Kingdom
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Re:Cognition Health - Bristol
Bristol, Bristol, City of, BS32 4SY, United Kingdom
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Re:Cognition Health - London
London, London, City of, W1G 9JF, United Kingdom
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Re:Cognition Health - Plymouth
Plymouth, PL6 8BT, United Kingdom
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Re:Cognition Health - Winchester
Winchester, Hampshire, SO21 1HU, United Kingdom
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Re:Cognition Health Guildford
Guildford, Reading, GU2 7YD, United Kingdom
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Renstar Medical Research
Ocala, Florida, 34470, United States
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Suncoast Clinical Research, Inc.
New Port Richey, Florida, 34652, United States
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The Cognitive and Research Center of New Jersey
Springfield, New Jersey, 07081, United States
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The University of Texas Health Science Center at Houston
Houston, Texas, 77054, United States
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Universal Research Group
Tacoma, Washington, 98405, United States
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VIN-Julie Schwartzbard
Aventura, Florida, 33180, United States