MENTAL DISORDERS

This study is testing if a mindfulness training program and regular pain management visits with a doctor can help people who have long-term pain and take opioid painkillers. The goal is to see if these approaches can reduce pain, improve daily life, and lower the risks associated…

This study is testing whether the drug donanemab is safe and effective at slowing the progression of early Alzheimer's disease. It will involve about 1,500 people who have mild memory problems and confirmed Alzheimer's-related brain changes. Participants will receive either the d…

This study is testing whether a new, fast-acting drug called (2R,6R)-HNK can help people with major depression who haven't gotten better with standard treatments. Fifty participants will receive intravenous infusions of either the study drug or a placebo over several weeks to see…

This study is testing whether a sedative drug called dexmedetomidine can prevent long-term memory and thinking problems that sometimes occur after heart surgery. It will involve 2,400 patients aged 60 and older who are having planned heart surgery. Researchers will compare the dr…

This study aims to better understand schizophrenia by looking for connections between brain structure, brain function, and genes. Researchers will collect brain scan data and blood samples from young adults recently diagnosed with schizophrenia and follow them for one year. The g…

This study aims to understand how the brain processes and controls emotions like fear and anxiety. Researchers will use mild electrical stimulation and recordings in 30 epilepsy patients who already have electrodes implanted for their medical care. The goal is to map brain circui…