MENTAL DISORDERS

This study tests a gamified mobile health app designed to reduce suicide risk in adults with mental disorders after they leave the hospital. Researchers will enroll 640 participants in Shenzhen, China, and use game-like features to encourage treatment adherence and follow-up visi…

This large trial tests whether the sedative dexmedetomidine can prevent long-term memory and thinking problems that often follow heart surgery. Researchers will give the drug to 2,400 adults aged 60 and older during and after their operation, then track their cognitive function f…

This study tests whether a new drug called HNK can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with their depression …

This study tests whether adding a group-based stabilization and skill-training program to regular individual therapy helps people with long-lasting post-traumatic stress recover better. About 160 adults receiving outpatient mental health care will take part. Half will get the com…

This pilot study tests whether adding ear acupressure (small seeds taped to ear points) to standard nicotine patches or gum can reduce cravings, withdrawal symptoms, and anxiety in psychiatric inpatients who must stop smoking during their hospital stay. Sixty participants will be…

This study tests two approaches—mindfulness training and patient-centered pain management visits—to help adults with chronic pain who take long-term opioids. The goal is to reduce pain, improve quality of life, and lower the risk of opioid misuse. About 300 participants will be f…

This study looks at how the brain processes emotions by using tiny electrical pulses in people with epilepsy who already have electrodes implanted for surgery. Researchers will measure brain activity and physical responses like sweat to understand how certain brain areas control …

This study looks at whether giving extra money to lower-income parents for three years can improve their children's mental health and brain function. Researchers will follow 500 children, ages 5 to 14 at the start, and measure stress, inflammation, and brain activity using scans.…

This study tests whether a 3-day training program called REFOCUS helps mental health teams provide care that supports personal recovery. About 760 people with severe mental disorders (like schizophrenia or bipolar disorder) will take part across 18 centers. Researchers will measu…

This study looks at brain activity in children with overactive bladder and daytime wetting compared to healthy children. Researchers use MRI scans to see if brain areas that control the bladder work differently. They also test if a gentle nerve stimulation treatment (TENS) change…

This study looks at how brain structure and gene activity in the blood are linked in people with early schizophrenia. About 1,899 participants, including healthy volunteers, will have brain scans and blood tests at the start and after one year of regular medication. The goal is t…