MENTAL DISORDERS

This study tests whether a sedative called dexmedetomidine can prevent long-term memory and thinking problems after heart surgery. About 2,400 adults aged 60 and older having planned heart surgery will receive either dexmedetomidine or standard care. Researchers will check their …

This study tests a drug called donanemab in 1,500 people with early Alzheimer's disease. The goal is to see if it can slow down memory and thinking problems. Participants receive the drug or a placebo for up to 93 weeks, and researchers track changes in daily function and dementi…

This study tests two approaches for adults with chronic pain who take long-term opioids: a mindfulness program called MORE and patient-centered pain management visits. The goal is to see if these methods can reduce pain, improve quality of life, and lower the risk of opioid misus…

This study tests a new drug called (2R,6R)-HNK to see if it can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with thei…

This study tests whether adding ear acupressure (small seeds taped to ear points) to standard nicotine patches can reduce cravings, withdrawal symptoms, and anxiety in psychiatric inpatients who must stop smoking while in the hospital. About 60 adults aged 18-65 will be randomly …

This study tests whether adding a group-based stabilization and skill-training program to regular individual therapy helps people with long-lasting post-traumatic stress. About 160 adults receiving outpatient mental health care will take part. Half will get the combined treatment…

This study looks at how brain structure and gene activity in the blood are linked in people with schizophrenia. Researchers will follow about 1,900 participants for one year, using brain scans and blood tests. The goal is to better understand the disease, not to test a new treatm…

This study looks at brain activity in children with overactive bladder and daytime wetting compared to healthy children. Researchers use brain scans to see if a nerve stimulation treatment changes how the brain controls the bladder. The goal is to understand why some children hav…

This study looks at how the brain manages emotions, especially fear, in people with epilepsy who already have electrodes implanted for surgery. Researchers will record brain activity and use mild electrical stimulation to see how certain brain areas talk to each other during emot…