NERVOUS SYSTEM DISEASES

This study is testing a new medical device called the Supernova stent retriever for treating acute ischemic strokes caused by large blood clots. The device is designed to physically remove clots from blocked brain arteries to restore blood flow. Researchers will enroll 100 stroke…

This study is testing if a simple, non-invasive treatment can help people recover better after a life-threatening brain bleed caused by a burst aneurysm. The treatment involves repeatedly inflating and deflating a blood pressure cuff on the arm or leg, which may trigger the body'…

This study is testing if combining virtual reality (VR) training with a gentle, non-invasive brain stimulation technique can help people recover arm and hand function after a stroke. Researchers will enroll 100 adults who had a stroke at least three months ago to see if this comb…

This study is testing the safety of an experimental virus therapy called G207 for children and young adults with recurrent or hard-to-treat brain tumors in the cerebellum. The virus is designed to infect and kill cancer cells while sparing healthy ones. Researchers will also test…

This study is testing whether the drug donanemab is safe and effective at slowing the progression of early Alzheimer's disease. It will involve about 1,500 people who have mild memory problems and confirmed Alzheimer's-related brain changes. Participants will receive either the d…

This study is testing a device that combines gentle magnetic brain stimulation with memory and thinking exercises. It aims to see if this non-invasive treatment can help slow or improve thinking problems in people with mild Alzheimer's disease. About 158 participants will receive…

This study is testing a smartphone app designed to help doctors and patients better understand and manage depression day by day. It will compare 200 adults with depression who use the app to track symptoms and medication with those receiving standard care. The goal is to see if u…

This program provides access to an investigational drug called AOC 1044 for eligible patients with Duchenne muscular dystrophy (DMD) who have a specific genetic mutation (amenable to exon 44 skipping). It is for patients aged 6 and older who are living in the US, including those …

This study tests whether a live video call between paramedics on scene and a hospital neurologist can improve the accuracy of diagnosing a stroke before the patient arrives at the hospital. Faster and more accurate diagnosis in the ambulance could help get patients the right trea…

This study is testing a portable, headset-like device that measures brain waves (EEG) to help ambulance crews quickly identify if a patient is having a severe type of stroke. The goal is to get these patients directly to the right specialized hospital for urgent treatment, avoidi…

This study is testing if becoming more physically active can help preserve memory and thinking skills in people with a specific sleep disorder that puts them at very high risk for developing Parkinson's disease or a related dementia. Researchers will use a motivational smartphone…

This study is testing a special home visit program for older adults with dementia who were recently hospitalized after a fall. The program, led by an occupational therapist, works with the patient and their caregiver to make the home safer and teach strategies to prevent future f…

This study is testing whether a sedative drug called dexmedetomidine can prevent long-term memory and thinking problems that sometimes occur after heart surgery. It will involve 2,400 patients aged 60 and older who are having planned heart surgery. Researchers will compare the dr…

This study is testing a non-invasive method to help people with chronic spinal cord injury who experience dangerous drops in blood pressure when they sit up, a condition causing dizziness and fatigue. Researchers will use gentle electrical stimulation on the skin over the spine w…

This study is testing if a gentle, non-invasive electrical stimulation on the spine can safely raise and stabilize low blood pressure in people who have had a recent spinal cord injury. It aims to help these individuals avoid dizziness and nausea when sitting up, which currently …

This study aims to build a collection of blood and spinal fluid samples from 1,000 patients with rare neurological diseases where the immune system may be attacking the nervous system. Researchers will analyze these samples to discover new biological markers that could help with …

This study aims to understand how a specific protein (BD-tau) in the blood changes in the first 48 hours after a stroke. Researchers will take blood samples every hour from 100 patients who have just had a stroke to see exactly when this marker rises and stops rising. The goal is…