NERVOUS SYSTEM DISEASES

This program provides access to an experimental drug, AOC 1044, for people with Duchenne muscular dystrophy (DMD) whose genetic mutation can be treated by skipping exon 44. The goal is to help control the disease by allowing the body to produce a shorter but still functional dyst…

This study tests whether a non-invasive treatment called remote ischemic conditioning (RIC) can help people recover after a serious brain bleed (aneurysmal subarachnoid hemorrhage) and aneurysm clipping surgery. RIC uses a blood pressure cuff on the arm to create short, harmless …

This study tests whether injecting a clot-dissolving medicine directly into the brain's arteries can improve recovery for people having a stroke caused by a medium-sized blood vessel blockage. About 282 adults with this type of stroke will be randomly assigned to receive either t…

This study tests a single dose of NTLA-2001, a gene-editing therapy, in 60 adults with hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN), a genetic disease that damages nerves. The goal is to see if the treatment can stop or slow the disease by lowering a harmfu…

This study tests a drug called donanemab in 1,500 people with early Alzheimer's disease. The goal is to see if it can slow down memory and thinking problems. Participants receive the drug or a placebo for up to 93 weeks, and researchers track changes in daily function and dementi…

This study tests whether a sedative called dexmedetomidine can prevent long-term memory and thinking problems that often occur after heart surgery. About 2,400 adults aged 60 and older having bypass or valve surgery will receive either dexmedetomidine or a placebo during their op…

This early-stage trial tests a specially engineered virus, G207, in children and young adults whose cerebellar brain tumors have come back or not responded to standard treatments. The virus is injected directly into the tumor, and a single low dose of radiation is given to help t…

This study tests a portable EEG device called StrokePointer that ambulance crews can use on people with suspected stroke. The goal is to quickly identify patients with a large vessel occlusion stroke who need to go directly to a hospital equipped for clot removal. About 275 adult…

This study tests whether increasing daily physical activity using a motivational smartphone app can slow cognitive decline in people with a sleep disorder that often leads to Parkinson's disease. Researchers will enroll 130 participants (80 with the sleep disorder and 50 healthy …

This study tests a non-invasive spinal stimulation technique to help people with a recent spinal cord injury (within 30 days) manage blood pressure drops when sitting up. Participants will receive both real and sham stimulation during a sit-up test to see if it can prevent dizzin…

This study tests whether combining virtual reality training with a gentle brain stimulation technique (tDCS) can improve arm and hand movement in people who have had a stroke. Researchers will enroll 100 adults who are at least 3 months post-stroke and have moderate arm weakness.…

This study is testing whether a smartphone app can help doctors better understand and treat depression. Researchers will track daily symptoms, medication use, and treatment response in 200 adults with depression. The goal is to improve care by giving doctors real-time insights fr…

This study tests a special home-based program (COTID) for people aged 75+ with dementia who were hospitalized after a fall. The program involves an occupational therapist making home safety changes and training a family caregiver to provide support. Researchers will track whether…

This study tests whether gentle electrical stimulation on the back can help people with chronic spinal cord injury maintain healthy blood pressure when they sit up. Participants will lie on a tilt table while their blood pressure is measured with and without stimulation. The goal…

This study tests a device called ATNC MDD-V1 that uses gentle magnetic pulses and brain exercises to improve thinking and memory in people with mild Alzheimer's. About 180 adults aged 60 to 85 who are already on stable Alzheimer's medication will receive either the real treatment…

This study aims to collect blood samples and medical data from 1000 people with rare neurological diseases that may be caused by the immune system attacking the body. The samples will be used by researchers to find new biomarkers and develop better treatments. Participants must h…

This study tests whether temporarily stimulating a specific part of the brain can improve hand, arm, and speech function in people who had a stroke at least 6 months ago. Ten participants will have a thin wire placed in the brain for less than 30 days to deliver mild electrical p…

This study tests whether a live video call between a neurologist and emergency medical technicians (EMTs) can improve the accuracy of stroke detection in the ambulance. About 512 adults with suspected stroke will be included. The goal is to see if video assistance helps diagnose …

This study tests a new brain scanning method called fNIRS to see if it can predict how unconscious patients with severe stroke or brain injury will recover. Researchers will compare fNIRS results with standard tests in 30 patients and healthy volunteers. The goal is to find a sim…

This study aims to understand how a protein called BD-tau, which is released into the blood when the brain is injured, changes over time in people having a stroke. Researchers will take blood samples every hour for 48 hours from 100 adults with acute ischemic stroke. The goal is …