BRAIN DISEASES

This study tests two drugs, elacestrant and abemaciclib, in people whose breast cancer has spread to the brain. The goal is to see if the combination can shrink or control brain tumors. About 73 adults with ER-positive, HER2-negative breast cancer will take part. The study is cur…

This study tests a special stent coated with rapamycin, a drug that helps keep arteries open, in people with narrowed brain arteries that have not improved with medication. About 300 participants will receive the stent and be followed for up to a year. The main goal is to see if …

This study tests whether a non-invasive treatment called remote ischemic conditioning (RIC) can help people recover after a serious brain bleed (aneurysmal subarachnoid hemorrhage) and aneurysm clipping surgery. RIC uses a blood pressure cuff on the arm to create short, harmless …

This study tests whether injecting a clot-dissolving medicine directly into the brain's arteries can improve recovery for people having a stroke caused by a medium-sized blood vessel blockage. About 282 adults with this type of stroke will be randomly assigned to receive either t…

This study tests a drug called donanemab in 1,500 people with early Alzheimer's disease. The goal is to see if it can slow down memory and thinking problems. Participants receive the drug or a placebo for up to 93 weeks, and researchers track changes in daily function and dementi…

This early-stage trial tests a specially engineered virus, G207, in children and young adults whose cerebellar brain tumors have come back or not responded to standard treatments. The virus is injected directly into the tumor, and a single low dose of radiation is given to help t…

This study tests a portable EEG device called StrokePointer that ambulance crews can use on people with suspected stroke. The goal is to quickly identify patients with a large vessel occlusion stroke who need to go directly to a hospital equipped for clot removal. About 275 adult…

This study tests whether increasing daily physical activity using a motivational smartphone app can slow cognitive decline in people with a sleep disorder that often leads to Parkinson's disease. Researchers will enroll 130 participants (80 with the sleep disorder and 50 healthy …

This study tests whether combining virtual reality training with a gentle brain stimulation technique (tDCS) can improve arm and hand movement in people who have had a stroke. Researchers will enroll 100 adults who are at least 3 months post-stroke and have moderate arm weakness.…

This study is testing whether a smartphone app can help doctors better understand and treat depression. Researchers will track daily symptoms, medication use, and treatment response in 200 adults with depression. The goal is to improve care by giving doctors real-time insights fr…

This study tests a device called ATNC MDD-V1 that uses gentle magnetic pulses and brain exercises to improve thinking and memory in people with mild Alzheimer's. About 180 adults aged 60 to 85 who are already on stable Alzheimer's medication will receive either the real treatment…

This study is tracking 350 adults with severe stroke caused by a blocked large artery in the brain. Researchers want to see how well a procedure called endovascular thrombectomy (which removes the clot) works in real-world hospitals across Asia-Pacific, not just in controlled cli…

This study tests a new way to make brain MRI scans clearer by fixing distortions caused by breathing. Researchers will compare standard images with ones corrected using a special navigator method in 100 adult patients. The goal is to see if the new method improves image quality w…

This study aims to understand if COVID-19 vaccines have any impact on brain health. Researchers will use MRI scans to look at the brains of 500 healthy adults in Hong Kong, comparing scans taken before and after vaccination. The goal is to provide clear, evidence-based informatio…

This study enrolls 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). Researchers want to understand why some strokes happen even when patients take blood thinners. They will collect blood samples and heart ultrasound images, then follow …

This study tests whether a live video call between a neurologist and emergency medical technicians (EMTs) can improve the accuracy of stroke detection in the ambulance. About 512 adults with suspected stroke will be included. The goal is to see if video assistance helps diagnose …

This study looks at how deep brain stimulation (DBS) changes brain activity and movement in people with conditions like Parkinson's disease and essential tremor. About 60 people scheduled for DBS surgery will have temporary brain recordings during their procedure. The goal is to …

This study looks at whether breathing low-oxygen air (hypoxic conditioning), either by itself or combined with exercise, can improve blood vessel health in the brains of older adults. Researchers will enroll 64 inactive people aged 60 to 80 to test this approach. The goal is to f…

This study looks at how blood flow and metabolism changes in the brain affect development in children with sickle cell anemia. Researchers will use MRI scans and a special mask to measure brain blood vessel function. The study includes 120 children aged 4-21, both with sickle cel…

This study is following 5,000 adults in Hong Kong who either have a brain disease (like stroke or dementia) or are at high risk. Researchers will collect medical records and survey data over time to identify what factors lead to brain diseases. The goal is to find ways to keep br…

This study aims to understand how a protein called BD-tau, which is released into the blood when the brain is injured, changes over time in people having a stroke. Researchers will take blood samples every hour for 48 hours from 100 adults with acute ischemic stroke. The goal is …