BRAIN DISEASES

This study is testing two medical devices called Supernova and Neutron that are designed to remove blood clots from brain arteries during a stroke. The goal is to restore blood flow quickly to minimize brain damage and help patients recover better. Researchers will track 3,000 st…

This study is testing whether delivering a clot-busting drug directly into a blocked brain artery can help people who have had a stroke caused by a blockage in a medium-sized vessel. About 282 adults who have had this specific type of stroke will be randomly assigned to receive e…

This study is testing whether a special camera can help neurosurgeons see the brain more clearly during surgery. The camera is designed to measure color and light changes that might indicate healthy versus diseased tissue or areas important for brain function. The goal is to prov…

This study aims to understand what causes headaches after a mild head injury. Researchers will give a hormone-like substance called pramlintide to 21 people with long-term post-traumatic headaches to see if it triggers their migraine-like pain. The goal is to learn more about the…

This study aims to understand if a natural brain chemical called adrenomedullin can trigger migraine attacks. Researchers will give participants a migraine prevention drug (erenumab) first to block one pathway, then give adrenomedullin to see if it still causes a migraine. The go…

This study aims to better understand two types of dangerous brain blood vessel abnormalities: arteriovenous malformations (AVMs) and aneurysms. Researchers will follow 630 patients over time to see how these conditions progress naturally and how well different treatments work. Th…

This study aims to understand what causes migraines by testing if a hormone-like drug called pramlintide can trigger a migraine attack. Researchers will give the drug or a placebo to 21 adults with migraine without aura and watch for 12 hours to see if a migraine starts. The goal…