BRAIN DISEASES

This study tests two devices, Supernova and Neutron, that are threaded through blood vessels to remove clots in people having a severe stroke. The goal is to restore blood flow to the brain within 24 hours of symptoms starting. About 3,000 participants will be followed for 90 day…

This study looks at whether pramlintide, a substance similar to a natural hormone, can cause migraine-like headaches in people who have had persistent headaches for at least a year after a mild traumatic brain injury. About 21 adults aged 18 to 65 will receive either pramlintide …

This study follows 30 adults who had a stroke causing severe arm weakness. Researchers will use brain scans (fMRI) to see how the brain changes and rewires over time. The goal is to better understand why some people recover more movement than others, which could help design bette…

This study looks at whether a natural brain chemical called adrenomedullin can cause migraine attacks in people who already get migraines. Researchers will give the chemical to 26 adults with migraine without aura, after they have taken a preventive migraine drug (erenumab). The …

This study tests whether a special camera can measure color changes in the brain during surgery to tell healthy tissue from diseased tissue. About 50 adults having brain surgery will be recorded. The goal is to see if the camera can provide useful information that might help surg…

This study looks at whether a substance called pramlintide, which is similar to a natural hormone (amylin), can cause migraine attacks in people who have migraine without aura. About 21 adults with a history of this type of migraine will receive either pramlintide or a placebo, a…

This study will follow 630 people with brain arteriovenous malformations (AVMs) and aneurysms to learn how these conditions behave and how well different treatments work. Researchers will track treatment success and complications over time. The goal is to better understand these …