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Headache trigger test: could amylin be the culprit?

NCT ID NCT07340775

Not yet recruiting Knowledge-focused Sponsor: Danish Headache Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study gives people with persistent post-traumatic headache a hormone called amylin (or a placebo) to see if it triggers migraine-like headaches. The goal is to understand why headaches continue after a mild brain injury. Only 21 adults will take part, and the results may help design future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

pramlintide (amylin analogue)

What this could lead to

If it works, this could help explain why some people get headaches after a head injury, pointing toward new treatment targets.

What could go wrong

This is a very small, early-phase study (21 people) that only looks at headache triggers, not treatment. Results may not apply to everyone with post-traumatic headache.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

brain disorder central nervous system disorder headache disorder Headache Disorders, Secondary nervous system disorder Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Post-Traumatic Headache Signs and Symptoms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMINO ACIDS, PEPTIDES, AND PROTEINS AMYLIN BRAIN DISEASES CENTRAL NERVOUS SYSTEM DISEASES HEADACHE DISORDERS HEADACHE DISORDERS, SECONDARY HORMONES HORMONES, HORMONE SUBSTITUTES, AND HORMONE ANTAGONISTS NERVOUS SYSTEM DISEASES NEUROLOGIC MANIFESTATIONS PAIN PATHOLOGICAL CONDITIONS, SIGNS AND SYMPTOMS PEPTIDE HORMONES PEPTIDES POST-TRAUMATIC HEADACHE PRAMLINTIDE SIGNS AND SYMPTOMS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Rigshospitalet Glostrup

    Glostrup Municipality, 2600, Denmark

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••