BRAIN DISEASES

This study is testing a new medical device called the Supernova stent retriever for treating acute ischemic strokes caused by large blood clots. The device is designed to physically remove clots from blocked brain arteries to restore blood flow. Researchers will enroll 100 stroke…

This study is testing a small, drug-coated tube (stent) placed inside a narrowed brain artery to keep it open and prevent future strokes. It will enroll 300 adults who have already had stroke symptoms and whose narrowed arteries haven't improved with medication alone. Researchers…

This study is testing if a simple, non-invasive treatment can help people recover better after a life-threatening brain bleed caused by a burst aneurysm. The treatment involves repeatedly inflating and deflating a blood pressure cuff on the arm or leg, which may trigger the body'…

This study is testing if combining virtual reality (VR) training with a gentle, non-invasive brain stimulation technique can help people recover arm and hand function after a stroke. Researchers will enroll 100 adults who had a stroke at least three months ago to see if this comb…

This study is testing the safety of an experimental virus therapy called G207 for children and young adults with recurrent or hard-to-treat brain tumors in the cerebellum. The virus is designed to infect and kill cancer cells while sparing healthy ones. Researchers will also test…

This study is testing whether the drug donanemab is safe and effective at slowing the progression of early Alzheimer's disease. It will involve about 1,500 people who have mild memory problems and confirmed Alzheimer's-related brain changes. Participants will receive either the d…

This study is testing a device that combines gentle magnetic brain stimulation with memory and thinking exercises. It aims to see if this non-invasive treatment can help slow or improve thinking problems in people with mild Alzheimer's disease. About 158 participants will receive…

This study is testing whether two drugs, elacestrant and abemaciclib, work together to control breast cancer that has spread to the brain. It will involve about 73 adults whose cancer is fueled by estrogen and has spread to the brain. The first part finds the safest dose, and the…

This study is testing a smartphone app designed to help doctors and patients better understand and manage depression day by day. It will compare 200 adults with depression who use the app to track symptoms and medication with those receiving standard care. The goal is to see if u…

This study tests whether a live video call between paramedics on scene and a hospital neurologist can improve the accuracy of diagnosing a stroke before the patient arrives at the hospital. Faster and more accurate diagnosis in the ambulance could help get patients the right trea…

This study is testing a new method to improve the quality of brain MRI scans by reducing blurring and distortions caused by a patient's breathing. It involves 100 adults already scheduled for a routine brain MRI at a Swedish hospital. The new technique processes the scan data dif…

This study is testing a portable, headset-like device that measures brain waves (EEG) to help ambulance crews quickly identify if a patient is having a severe type of stroke. The goal is to get these patients directly to the right specialized hospital for urgent treatment, avoidi…

This study is testing if becoming more physically active can help preserve memory and thinking skills in people with a specific sleep disorder that puts them at very high risk for developing Parkinson's disease or a related dementia. Researchers will use a motivational smartphone…

This study aims to understand how blood flow and oxygen delivery affect brain development in children and young adults with sickle cell anemia. Researchers will use MRI scans and a special breathing test to measure how well blood vessels in the brain can expand when needed. The g…

This study aims to follow 5000 adults over many years to understand what factors lead to brain diseases like stroke and dementia. It will track people who already have a diagnosis, are at high risk, or are currently healthy, using questionnaires and medical records. The goal is t…

This study aims to understand if COVID-19 vaccines affect brain health, specifically looking for signs of stroke or dementia. Researchers in Hong Kong will follow 500 healthy adults, comparing brain scans and memory tests from before and after vaccination to those from unvaccinat…

This study aims to understand how deep brain stimulation (DBS) works to improve movement and speech in people with conditions like Parkinson's disease or essential tremor. Researchers will test 60 patients who are already scheduled for DBS surgery, adding extra measurements durin…

This study aims to understand how well a proven emergency stroke treatment works in everyday hospital practice across the Asia-Pacific region. Researchers will follow 350 adult stroke patients to see what factors help or hinder successful treatment in real-world settings, compare…

This study aims to understand why some people with atrial fibrillation (AF, an irregular heartbeat) still have a stroke even while taking blood-thinning medication. Researchers will follow 500 stroke patients with AF for about a year, collecting blood samples and heart scan data.…

This study aims to understand how a specific protein (BD-tau) in the blood changes in the first 48 hours after a stroke. Researchers will take blood samples every hour from 100 patients who have just had a stroke to see exactly when this marker rises and stops rising. The goal is…