NEURODEGENERATIVE DISEASES

This study tests whether a natural brain hormone called allopregnanolone can safely slow or reverse memory loss in people with early-stage Alzheimer's. About 100 adults aged 55-80 will receive either the drug or a placebo for several months. The main goal is to see if the drug ca…

This study tests a single dose of NTLA-2001, a gene-editing therapy, in 60 adults with hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN), a genetic disease that damages nerves. The goal is to see if the treatment can stop or slow the disease by lowering a harmfu…

This study tests a drug called donanemab in 1,500 people with early Alzheimer's disease. The goal is to see if it can slow down memory and thinking problems. Participants receive the drug or a placebo for up to 93 weeks, and researchers track changes in daily function and dementi…

This study is testing whether a virtual reality (VR) platform called VIRADIA can accurately measure thinking and movement skills, like attention, balance, and hand coordination. About 200 healthy adults and people with neurological conditions (such as Parkinson's or multiple scle…

This study is testing a new, non-invasive eye scan that uses different colors of light to look for signs of brain diseases like Alzheimer's, Parkinson's, and dementia. Researchers will scan the eyes of 930 adults aged 30 and older, including those with these conditions and health…

This study tests whether increasing daily physical activity using a motivational smartphone app can slow cognitive decline in people with a sleep disorder that often leads to Parkinson's disease. Researchers will enroll 130 participants (80 with the sleep disorder and 50 healthy …

This study tests a device called ATNC MDD-V1 that uses gentle magnetic pulses and brain exercises to improve thinking and memory in people with mild Alzheimer's. About 180 adults aged 60 to 85 who are already on stable Alzheimer's medication will receive either the real treatment…

This study aims to understand how inflammation in the brain contributes to Parkinson's disease. Researchers will give a mild inflammatory substance (LPS) to 30 participants, including people with Parkinson's, those with REM sleep behavior disorder, and healthy volunteers. They wi…

This study uses special brain scans (PET, SPECT, and MRI) to learn more about the brain changes that happen in Parkinson's disease. Researchers want to find a biological marker that could help develop new medicines to slow down the disease. The study involves 42 adults aged 25 to…

This study uses special brain scans (PET, SPECT, and MRI) to find markers of Parkinson's disease in people with certain genetic mutations. Researchers will look at changes in brain chemicals and structure to better understand the disease. The goal is to help develop new treatment…

This study aims to uncover the genetic causes of hereditary spastic paraplegia (HSP), a group of rare nerve diseases that cause progressive muscle stiffness and disability. Researchers will analyze DNA from 200 children and adults with HSP to find gene variants linked to the cond…

This study aims to find a biological marker for Parkinson's disease by using special brain scans (PET, SPECT, and MRI). Researchers will track 44 participants over time to see how certain brain cells and chemicals change as the disease progresses. The goal is to better understand…

This study looks at whether being bilingual helps people with primary progressive aphasia (PPA) respond better to speech therapy. Researchers will give tailored language treatment in both languages to 60 bilingual Spanish speakers and track their progress for a year. Another 30 p…

This study aims to find digital markers of brain energy changes in people with mild cognitive impairment or early Alzheimer's. Researchers will use passive home sensors to measure sleep, movement, and walking speed over 12 weeks. Participants take a daily supplement called nicoti…