NEURODEGENERATIVE DISEASES

This study is testing whether the drug donanemab is safe and effective at slowing the progression of early Alzheimer's disease. It will involve about 1,500 people who have mild memory problems and confirmed Alzheimer's-related brain changes. Participants will receive either the d…

This study is testing whether a weekly infusion of a natural hormone called Allopregnanolone can help repair brain structure and slow memory loss in people with mild Alzheimer's disease. About 100 participants will receive either the treatment or a placebo for six months, with br…

This study is testing a device that combines gentle magnetic brain stimulation with memory and thinking exercises. It aims to see if this non-invasive treatment can help slow or improve thinking problems in people with mild Alzheimer's disease. About 158 participants will receive…

This study is checking if a new virtual reality (VR) system can accurately test brain function and movement, just like standard paper or face-to-face exams. Researchers will have 200 participants—some healthy and some with neurological conditions—take the same tests in both VR an…

This study is testing if becoming more physically active can help preserve memory and thinking skills in people with a specific sleep disorder that puts them at very high risk for developing Parkinson's disease or a related dementia. Researchers will use a motivational smartphone…

This study aims to understand if speech therapy tailored for bilingual people can help those with primary progressive aphasia, a condition that causes worsening language problems. Researchers will test 60 bilingual participants to see if practicing in both their languages improve…

This study aims to find a measurable sign, or biomarker, of Parkinson's disease progression. Researchers will use specialized brain scans (PET, SPECT, and MRI) on 44 participants to look at chemical and structural changes over a one-year period. The goal is to better understand t…

This study aims to understand the role of brain inflammation in Parkinson's disease. Researchers will compare 30 people with Parkinson's to healthy volunteers. They will use special brain scans before and after giving a compound that causes a mild, temporary inflammatory response…

This study aims to better understand Parkinson's disease by looking at brain chemistry and structure. Researchers will use advanced brain imaging scans (PET, SPECT, and MRI) on 42 participants aged 25-85 to identify biological markers of the disease. The findings could help guide…

This study aims to find a measurable sign, or biomarker, of Parkinson's disease using advanced brain scans. Researchers will scan 45 people who carry genetic mutations linked to Parkinson's to better understand brain changes. The goal is to gather knowledge that helps develop fut…

This study aims to understand the genetic causes of hereditary spastic paraplegia (HSP), a group of rare inherited disorders that cause progressive muscle stiffness and weakness. Researchers will analyze DNA from 200 participants who have been diagnosed with progressive spasticit…

This study aims to see if a small, contactless device placed in the bedroom can detect subtle changes in sleep patterns, walking speed, and daily activity in people with mild memory problems or early Alzheimer's disease. About 40 participants will have the device monitor them at …