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Brain scan tracer could reveal hidden signs of psychosis in Parkinson's

NCT ID NCT05357612

Recruiting now Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This study uses a special PET scan tracer, [18F]MH.MZ, to measure serotonin 2A receptors in the brains of people with neurodegenerative diseases like Parkinson's. Researchers want to see if these receptors differ between patients with psychosis and healthy people of the same age. Some participants will also take the drug pimavanserin to see how it affects receptor binding. The goal is to better understand the brain changes behind psychosis in these diseases.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a radioactive PET tracer called [18F]MH.MZ, and the drug pimavanserin for some participants
What this could lead to
If successful, this could help doctors better understand and diagnose psychosis in neurodegenerative diseases like Parkinson's.
What could go wrong
This is an early-stage imaging study, not a treatment trial. The tracer may not reliably distinguish between patient groups, and results may not lead to direct clinical benefits.

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Conditions

The condition(s) this trial relates to.

frontotemporal dementia Huntington disease Lewy body dementia multiple system atrophy neurodegenerative disease Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEURODEGENERATIVE DISEASES PARKINSON DISEASE PARKINSON DISEASE PSYCHOSIS

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Vanderbilt University Medical Center

    RECRUITING

    Nashville, Tennessee, 37212, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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