Scientists hunt for genetic clues to rare paralysis disorder

NCT ID NCT05354622

Recruiting now Knowledge-focused Sponsor: Boston Children's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aims to uncover the genetic causes of hereditary spastic paraplegia (HSP), a group of rare neurological diseases that cause progressive muscle stiffness and weakness. Researchers at Boston Children's Hospital will analyze DNA from 200 people with HSP to find genetic variants linked to the condition. The goal is to improve diagnosis and eventually develop better treatments based on each person's genetic profile.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could identify genetic causes of HSP, paving the way for targeted treatments in the future.
What could go wrong: This is an observational study, not a treatment trial. It may not directly benefit participants, and finding meaningful genetic links is not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hereditary disease hereditary spastic paraplegia hereditary spastic paraplegia 26 hereditary spastic paraplegia 3A motor neuron disorder movement disorder Muscle Spasticity musculoskeletal system disorder neurodegenerative disease neurodevelopmental disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEREDITARY SPASTIC PARAPLEGIA MOTOR NEURON DISEASE MOVEMENT DISORDERS NEURODEGENERATIVE DISEASES PEDIATRIC DISORDER SPASTICITY, MUSCLE

Contacts and locations

Locations

Boston Children's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States

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