MOTOR NEURON DISEASE

This early study is testing a device called a brain-computer interface that is implanted into a blood vessel in the brain. It is designed to help people with ALS who have weakness in both arms control external devices, like a computer, using only their thoughts. The study will in…

This study tests a brain-computer interface (BCI) implant for people with ALS or motor neuron disease who have weakness in both arms. The device aims to let them control computers or other devices just by thinking. The main goal is to check safety, such as serious side effects or…

This study tests whether a smartphone app can record and analyze speech to help diagnose and monitor neurodegenerative conditions like dementia, Parkinson's disease, multiple sclerosis, and motor neuron disease. Researchers will compare speech patterns from 150 people with these …

This study explores whether a non-invasive brain-computer interface (BCI) can help people with motor disorders (like spinal cord injury, stroke, or multiple sclerosis) control assistive devices just by thinking about moving. Researchers will use EEG to read brain signals and comb…

This study aims to find better ways to measure how spinal and bulbar muscular atrophy (SBMA) progresses. Researchers will follow 70 men with and without SBMA for up to 2 years, using muscle tests, imaging scans, and lab tests. The goal is to identify reliable markers of disease c…

This study looks at how physical abilities impact the quality of life for people with ALS, a disease that weakens muscles over time. About 30 adults with ALS will fill out questionnaires about their daily function and well-being during regular clinic visits for up to two years. N…

This study is testing a new, painless technique called electrical impedance myography (EIM) to measure muscle health. Researchers will use a mild electric current on the skin to see how it travels through muscles in both healthy volunteers and people with neuromuscular diseases. …

This study aims to uncover the genetic causes of hereditary spastic paraplegia (HSP), a group of rare nerve diseases that cause progressive muscle stiffness and disability. Researchers will analyze DNA from 200 children and adults with HSP to find gene variants linked to the cond…

This study is creating a large collection of biological samples—like blood, spinal fluid, and urine—from 800 people with ALS and 200 healthy volunteers. Researchers will also track participants' health over time using clinic visits and at-home tests. The goal is to provide this d…

This study looks at people with inherited neurological disorders to learn how these diseases develop and change over time. Researchers will collect medical history, do physical exams, and take blood or skin samples for genetic testing. Up to 3,500 children and adults with these r…