MOVEMENT DISORDERS

This study is collecting real-world information on how a specific brain ablation procedure affects patients' quality of life. It will follow 200 people with Parkinson's disease, dystonia, or essential tremor who are scheduled to receive the treatment. The goal is to understand th…

This study is a long-term registry tracking 60 people with advanced Parkinson's disease who have already received a specific, approved brain procedure. The procedure uses focused ultrasound to create a small lesion in a part of the brain to help control severe movement problems t…

This National Institutes of Health study provides botulinum toxin (like Botox) injections to treat movement disorders such as dystonia, tremors, and muscle spasms. It serves two main purposes: training doctors in proper injection techniques and maintaining a group of patients for…

This study aims to collect long-term safety and effectiveness data on Abbott's deep brain stimulation (DBS) systems. It will follow 1,000 patients with Parkinson's disease, essential tremor, or dystonia for five years after their device is implanted and programmed. The goal is to…

This study is testing whether a new, non-invasive brain stimulation technique can help reduce tremors and improve walking in people with Parkinson's disease. Researchers will compare the effects of real stimulation to a fake (sham) stimulation in 50 participants. The goal is to s…

This study is testing two different exercise schedules for Veterans with moderate Parkinson's disease. It compares a high-volume schedule (intense weeks followed by rest) to a steady, moderate weekly schedule. The goal is to see which approach better improves walking speed, daily…

This study is testing whether weekly mindfulness sessions, attended together by a person with Parkinson's and their main caregiver, can help reduce stress and improve their relationship. Researchers will enroll 100 pairs in Hong Kong, with half receiving the mindfulness program a…

This study is testing a lightweight, wearable robotic suit (an exoskeleton) designed to help people with leg stiffness (spasticity) from spinal cord injuries. The goal is to see if the device can safely stretch the legs and assist with walking, potentially improving movement and …

This study aims to build a large collection of blood, spinal fluid, and health information from people with ALS and healthy volunteers. Researchers will follow 800 ALS patients and 200 healthy controls for up to 5 years, collecting samples and tracking symptoms. The goal is to cr…

This study aims to better understand rare genetic disorders that cause both epilepsy and movement problems in children. Researchers are collecting medical history and genetic information from 500 children worldwide who have these conditions. By analyzing this data, they hope to f…

This study aims to understand the genetic causes of hereditary spastic paraplegia (HSP), a group of rare inherited disorders that cause progressive muscle stiffness and weakness. Researchers will analyze DNA from 200 participants who have been diagnosed with progressive spasticit…

This study aims to understand how brain activity relates to symptoms in movement disorders like Parkinson's disease, essential tremor, dystonia, and ataxia. Researchers will record brain signals from 100 adult patients, either from the scalp or through a deep brain stimulator if …

This study aims to develop computer algorithms that can interpret brain and body signals to control assistive devices like robotic arms or wheelchairs. Researchers are testing these systems with 50 healthy volunteers who will wear non-invasive sensors while performing or imaginin…