MOVEMENT DISORDERS

This study tracks people with advanced Parkinson's disease who have a procedure called Exablate pallidotomy. The procedure uses focused ultrasound to target a small area in the brain to reduce medication-resistant motor complications like tremors and stiffness. Researchers will f…

This study uses botulinum toxin (Botox) injections to treat movement disorders like dystonia, tremors, and spasms. It aims to improve symptoms and train doctors in injection techniques. Up to 2000 people aged 2 and older with these conditions can join. Treatment is ongoing and do…

This study follows 1000 people with movement disorders like Parkinson's disease, essential tremor, and dystonia who receive an Abbott deep brain stimulation (DBS) system. Researchers will measure changes in movement symptoms and track any serious side effects for up to 5 years. T…

This study looks at two different exercise plans for veterans with moderate Parkinson's disease. One group exercises a lot for one week, then rests for three weeks. The other group exercises every week without breaks. Researchers will measure walking speed, daily activity levels,…

This study is testing a portable, wearable leg exoskeleton to help people with spasticity (muscle stiffness) due to spinal cord injury. Ten veterans will use the device for leg stretching, treadmill walking, and overground walking to see if it improves joint motion, muscle activi…

This study tests whether an 8-week mindfulness program for people with Parkinson's disease and their family caregivers can reduce negative emotions and improve their relationship. About 200 Chinese patient-caregiver pairs will either take the mindfulness classes or continue usual…

This study tests a non-invasive brain stimulation method called temporal interference stimulation (TIS) to see if it can reduce tremors and improve walking in people with Parkinson's disease. Researchers will compare real stimulation to a sham (fake) treatment in 50 adults aged 5…

This study aims to develop algorithms that can help people with paralysis control assistive devices like robotic arms or wheelchairs using their brain and body signals. Healthy participants will wear non-invasive sensors (such as EEG or muscle activity monitors) and perform or im…

This study explores whether a non-invasive brain-computer interface (BCI) can help people with motor disorders (like spinal cord injury, stroke, or multiple sclerosis) control assistive devices just by thinking about moving. Researchers will use EEG to read brain signals and comb…

This study aims to better understand the brain activity behind movement disorders like Parkinson's disease, essential tremor, dystonia, and ataxia. Researchers will record electrical signals from the scalp or from implanted deep brain stimulation devices in 100 adults. They will …

This study aims to see if a new computer algorithm can accurately measure how many calories people with movement limitations burn each day. Researchers will compare readings from a wearable accelerometer against a precise water-based test. The study involves 125 adults who can wa…

This study aims to uncover the genetic causes of hereditary spastic paraplegia (HSP), a group of rare nerve diseases that cause progressive muscle stiffness and disability. Researchers will analyze DNA from 200 children and adults with HSP to find gene variants linked to the cond…

This study is creating a shared database of children who have had deep brain stimulation (DBS) for conditions like dystonia, epilepsy, or Tourette syndrome. By collecting information from multiple hospitals, researchers hope to learn which children benefit most, which brain targe…

This study is gathering information from 200 people with Parkinson's disease, dystonia, essential tremor, or other movement disorders who are already scheduled to receive radiofrequency (RF) ablation as part of their routine care. The goal is to see how this treatment affects qua…

This study is creating a large collection of biological samples—like blood, spinal fluid, and urine—from 800 people with ALS and 200 healthy volunteers. Researchers will also track participants' health over time using clinic visits and at-home tests. The goal is to provide this d…

This study looks at brain activity in people with Parkinson's disease or essential tremor who are already scheduled for deep brain stimulation (DBS) surgery. Researchers want to understand how the brain handles both movement problems and non-motor issues like memory or mood chang…

This study looks at children who have both epilepsy (seizures) and movement problems like twitching or trouble controlling muscles. Researchers will collect medical and genetic information from 500 children across many countries. The goal is to learn more about these rare conditi…