DEMENTIA

This study tests whether changing the dose schedule of donanemab can lower the risk of a brain swelling side effect called ARIA-E while still clearing amyloid plaques. About 1,175 adults with early symptomatic Alzheimer's will receive different dosing regimens over 91 weeks. The …

This study tests a heart medication, nicorandil, as a possible treatment for hippocampal sclerosis of aging — a brain condition that looks like Alzheimer's but is different. Researchers want to see if the drug is safe and can slow brain shrinkage in people aged 75 and older with …

This study tests a device that delivers light and sound stimulation to people with mild to moderate Alzheimer's disease. About 670 participants will use either the active device or a sham (inactive) device for one hour daily over 12 months. The goal is to see if the stimulation c…

This study tests whether giving tranexamic acid before major gastrointestinal surgery can lower the chance of delirium (sudden confusion) after the operation. Delirium is common in older or frail patients and may be caused by inflammation harming the brain. The trial involves 826…

This study tests the drug lecanemab in 40 people who have a genetic form of Alzheimer's disease. The goal is to see if removing amyloid plaques from the brain can delay the start of symptoms or slow the disease. Participants previously received another anti-amyloid drug and will …

This study tests whether experimental drugs can slow down memory and thinking problems in people who have a genetic mutation that causes Alzheimer's disease. About 490 adults aged 18-80 with a family history of early-onset Alzheimer's will receive either the study drug or a place…

This study tests whether deep brain stimulation (DBS) can improve thinking and memory in people recently diagnosed with early Alzheimer's disease. Two participants will have electrodes implanted in a brain area that produces a key memory chemical. The goal is to see if daily one-…

This study tests whether adding an experimental drug (E2814) to a standard Alzheimer's treatment (lecanemab) can slow memory loss and brain changes in people who have a genetic mutation that causes Alzheimer's. About 197 adults aged 18-80 with mild symptoms or no symptoms but car…

This study tests a new tool called ToolBoxDetect that helps doctors quickly and easily check for early signs of memory loss or dementia during regular visits. About 41,500 adults aged 65 and older from diverse primary care clinics will take a short computer-based test. The goal i…

This study looks at a new way to analyze brain scans, called Cortical Disarray Measurement (CDM), to see if it can help diagnose Alzheimer's disease more accurately. Researchers will follow 400 people with mild memory or thinking problems over time. The goal is to see if CDM chan…

This study is developing a web application that lets people test their own speech and memory from home. It uses machine learning to analyze speech patterns for early signs of conditions like Alzheimer's or dementia. The goal is to catch cognitive problems early so people can get …

This study tests a website called 'Small Steps' that helps people aged 65 and older make small changes to their daily habits—like sitting less, moving more, and sleeping better—to lower their risk of dementia. Participants use the website for 36 weeks and are randomly placed in e…

This study looks at whether carefully stopping certain medications (called anticholinergics) can help prevent dementia in older adults. 344 people aged 65 and older who take these drugs are being followed for two years. Researchers will compare thinking skills, mood, and quality …

This study tests whether a special diet called the MIND diet can help prevent memory loss and dementia in people who have had a stroke. Researchers will compare the MIND diet to usual post-stroke care in 250 adults aged 55 and older. The goal is to see if the diet protects the br…

This study is following older adults for six years to see if using hearing aids can slow down memory loss and thinking problems, and possibly reduce the risk of dementia. It continues a previous 3-year trial where half the participants received hearing aids and the other half rec…

This study tests a 6-week online program called Learning Skills Together (LST) for family caregivers of people with Alzheimer's or related dementias. The program teaches practical caregiving skills to help caregivers feel more confident and less depressed. About 216 caregivers wi…

This study tests whether adding MK-1167 to standard Alzheimer's medication can improve memory and thinking in people with mild to moderate Alzheimer's dementia. About 350 participants will receive either MK-1167 or a placebo for 24 weeks. The main goals are to see if the drug imp…

This study tests whether adding sodium benzoate (a common food preservative) to a non-invasive brain stimulation technique called tDCS can improve thinking and daily function in people with early Alzheimer's or mild cognitive impairment. About 140 participants will receive tDCS f…

This study tests a program that focuses on the strengths of people with mild dementia and their family caregivers, rather than their limitations. The program aims to improve thinking skills and make caregiving feel more manageable. About 272 older adults with mild dementia or mil…

This study tests a home-based exercise program for older adults with mild cognitive impairment or dementia. Participants play a special video game that challenges balance and thinking, while a coach supervises them remotely via telemedicine. The goal is to see if this approach ca…

This study tests a nature-based program led by caregivers for people with mild cognitive impairment or dementia living at home. About 48 pairs (a person with memory issues and their caregiver) will be randomly assigned to either start the program right away or wait. The program i…

This study looks at whether a 12-month nurse-led program can help people with mild cognitive impairment or dementia and their caregivers. About 200 participants from a Stanford research center will either get monthly nurse support or standard care. The goal is to improve symptoms…

This study tests a website tool called WeCareToFeedDysphagia designed to reduce stress and burden for people caring for older adults with Alzheimer's or related dementias who also have trouble swallowing. About 800 caregivers will either get access to the tool or not, and all wil…

This study is testing a specially designed garment for elderly people with dementia who have incontinence and often remove their protective pads. The goal is to create a more dignified and comfortable option that reduces stress for both patients and caregivers. About 40 participa…

This study tests whether a combination of two cannabis ingredients (THC and CBD) can reduce agitation in people with dementia who are eligible for hospice care. About 120 participants will receive either the study drug or a placebo for 12 weeks. The main goal is to see if agitati…

This study tests a special guide (Swedish Palliative Care Guide) to help nursing home staff provide better care for older adults, including those with dementia. The goal is to make patients and families feel more informed and secure about future care. About 400 residents will tak…

This study tests whether watching 10-minute virtual reality nature videos twice a week for 12 weeks can improve quality of life and mood in nursing home residents with dementia. Sixty residents will be randomly assigned to either the virtual nature group or continue their usual c…

This study tests whether adding a caregiver training program to a visual mapping app (MapHabit) improves daily life for people with Alzheimer's or dementia and reduces stress for their caregivers. Fifty patient-caregiver pairs will use the app for six months, with half also recei…

This study looks at whether playing motion-based games like Wii or the Magic Table can help older adults with mild to moderate dementia feel more engaged and positive. Twenty participants from a community adult day care will either play these games or do regular activities for 10…

This study tests a therapy program delivered remotely via technology for people with mild cognitive impairment or dementia who also have anxiety. The goal is to see if this approach can reduce anxiety and improve quality of life. The study involves 70 participants and uses a rand…

This study tests a special exercise program for older Veterans with dementia living in VA nursing homes. The program, called PLIÉ, combines gentle movement and mental focus to improve physical function, mood, and social engagement. Staff will be trained to lead the classes, and r…

This study tests an online training program for nursing home staff to improve how they talk with residents who have Alzheimer's or other dementias. The goal is to reduce challenging behaviors like agitation or refusal of care. Over 5,000 staff members from nursing homes across th…

This study tests a 12-week coaching program called CuRB-IT for family caregivers of people with dementia. 266 caregivers are randomly assigned to start the program right away or after a delay. The goal is to see if the program reduces care-resistant behaviors and helps caregivers…

This study tests an online Emergency Preparedness Toolkit for caregivers of people with dementia. The toolkit helps caregivers identify a backup caregiver so they can focus on their own health needs during an emergency. About 68 caregivers aged 55 and older who live with their pa…

This study tests whether two different essential oil blends can help people with dementia who experience sundowning (agitation in the late afternoon) and poor sleep. About 35 people living in long-term care facilities will try both formulas at different times. The goal is to see …

This study looks at whether joining a community choir can reduce loneliness for people with dementia and their family or friend caregivers. About 100 participants will take part in choir sessions, and researchers will measure changes in loneliness, mood, and well-being over sever…

This study tests whether providing palliative care at home can improve symptom management for people with advanced dementia and reduce stress for their family caregivers. About 150 patient-caregiver pairs from New York City hospitals will receive either the in-home care program o…

This study explores whether teaching older adults with early-stage dementia how to use aromatherapy through augmented reality (AR) can improve their mood and behavior. 300 participants in Taiwan will be randomly assigned to either AR-based aromatherapy sessions or standard activi…

This study looks at whether training volunteers to visit older adults with memory loss or dementia can improve the volunteers' skills and reduce loneliness in the people they visit. About 342 volunteers and clients in Minnesota are taking part. The training is part of the volunte…

This study looks at whether people with memory problems will wear and use digital devices like smartwatches, sleep headbands, and smartphone apps to collect health data. Researchers will combine this data with routine clinic information to build machine learning models that might…

This study looks at the link between eating nuts and the risk of developing serious diseases like diabetes, heart disease, cancer, and dementia. Researchers will combine data from over 1 million adults worldwide to get clearer answers. The goal is to understand if nuts can help p…

This study asks 1,000 people with neurological diseases like Alzheimer's or Parkinson's, and their caregivers, to share their experiences using a head device called MemorEM. The goal is to learn how to make the device better and easier to use in future studies. No treatment is gi…

This study reviews past data and interviews 350 caregivers who took part in a telehealth education program for dementia. The goal is to see if the program helped reduce caregiver stress and improve their experience. Researchers will measure things like memory problems, depression…

This study follows over 19,000 older adults who previously took aspirin in a clinical trial. Researchers are monitoring for long-term effects, especially on cancer, dementia, and disability. No new treatment is given—participants just continue regular check-ups and phone calls to…

This early-stage study tests whether a daily pill called MIB-626 can enter the brain and affect aging-related pathways in people with mild Alzheimer's disease. Researchers will measure the drug and its byproducts in spinal fluid and use advanced brain scans to see if it boosts NA…

This study from Stanford University uses cameras and sensors placed in the homes of 25 older adults (65+) to automatically track behaviors like mood changes and agitation. The goal is to see if this technology can help doctors detect early signs of memory problems or dementia. Pa…

This study looks at why some ICU patients develop long-term memory or thinking problems after leaving the hospital. Researchers are tracking 826 adults who were in the ICU for serious conditions like respiratory failure or shock. They aim to find which factors, such as delirium o…

This study looks at how changes in small brain blood vessels, called cerebral amyloid angiopathy (CAA), may contribute to dementia, especially in Alzheimer's disease. Researchers will use special MRI scans to measure blood vessel reactivity in 120 people, including healthy contro…

This study looks at how often antiepileptic drugs and other psychoactive medications are prescribed in US nursing homes, especially before and after the COVID-19 pandemic. Researchers will analyze data from millions of long-stay residents to see if these drugs are being used more…

This study uses a special brain scan called DaTSCAN to learn more about aging and diseases like dementia, Parkinson's, and mild cognitive impairment. Researchers will compare scan results with clinical diagnoses and other brain images to better understand these conditions. The st…

This study follows 600 people with and without chronic kidney disease (CKD) for up to 4 years to see how memory, thinking, and daily activities change over time. Researchers will compare the two groups and look for risk factors that may lead to cognitive decline, dementia, or str…

This study interviews 6 healthcare support workers in a hospital to understand how they respond to distressed behaviors in people with dementia. The goal is to learn from their experiences and use those insights to improve future training for care staff. No treatments or medicati…

This study aims to find better ways for doctors and patients to talk about what matters most when facing a serious illness like cancer, heart failure, COPD, or dementia. Researchers will track how often and how early these conversations happen in the last six months of life. The …

This study looks at blood markers for Alzheimer's and related dementias in over 13,000 older adults. Researchers want to see if these markers change differently over time in men versus women, and how health conditions and genetics affect them. The goal is to create a personalized…

This study aimed to test a tracking system called Care Companion for family caregivers of people with dementia who are at risk of wandering. It was designed in two stages: first to see if the system was easy to use, and second to measure its effect on caregiver well-being. Howeve…

This study will enroll 100,000 adults aged 45 and older to track early signs of Alzheimer's and Parkinson's disease using phone apps, voice recordings, and movement tests. Researchers aim to create better tools for early diagnosis by combining digital data with genetic and biolog…

This study is testing whether blood tests can accurately diagnose dementia in everyday clinics. Researchers will collect blood samples and questionnaires from 3,165 adults aged 45 and older with memory problems. The goal is to see if these tests are reliable, acceptable to patien…

This study was designed to collect walking data from people with Parkinson's disease, dementia, multiple sclerosis, and other conditions using special sensors worn during daily activities. The goal was to use this data to improve remote diagnosis and fall prevention. However, the…

This study looks at whether trained community health workers can help Korean American elders with possible dementia and their caregivers. About 288 pairs (elder and caregiver) will either get the program or usual care. The goal is to see if the program helps elders get medical ca…

This study from Yale University looks at how live music affects the brains and bodies of people with early Alzheimer's, dementia, or mild cognitive impairment, along with their caregivers. About 60 pairs (patient and caregiver) will listen to live and recorded music while wearing…

This study checks if a Turkish translation of two short quizzes about dementia and urinary incontinence works well for older adults. About 230 people aged 55 and older who can read and write will take the quizzes. The goal is to see how much seniors in the community know about th…

This study looks at whether a virtual reality (VR) education program can improve nursing students' attitudes and knowledge about dementia. About 200 Indonesian nursing students will take part in a single 100-minute class that includes VR experiences, lectures, and discussions. Th…

This long-term study follows 1,500 adults with normal memory, mild cognitive impairment, or Alzheimer's disease. Researchers use brain scans, memory tests, and genetic data to understand how the disease progresses and to improve future clinical trials. The study also aims to incl…

This study looks at whether an interactive virtual reality (VR) game can help nursing students learn about dementia. About 200 Indonesian nursing students will take part in a 30-minute class that includes role-playing with an AI character who has dementia. Researchers will measur…

This study looks at why people with Alzheimer's and other dementias become agitated or aggressive. Researchers will use gentle magnetic and electrical brain stimulation to understand the brain changes behind these symptoms. They will also test if a mild electrical current (tDCS) …

This study looks at how common dementia and memory problems are in Mexican American and non-Hispanic white adults aged 65 and older. Researchers will track changes in thinking skills over time and explore what support patients and their caregivers need. The goal is to find better…

This study aims to better understand how different types of dementia affect the brain over time. Researchers are using advanced brain scans, genetic tests, and yearly cognitive assessments to track changes in nearly 2,000 participants with various dementia types. The goal is to i…