DEMENTIA

This clinical trial is testing several different drugs to see if they can slow down or prevent cognitive decline in people who carry genetic mutations that cause inherited Alzheimer's disease. The study includes 490 participants who either have early symptoms or are still symptom…

This study is testing different dosing schedules for the Alzheimer's drug donanemab to find the best balance between clearing harmful brain plaques and minimizing a serious side effect called ARIA-E, which is brain swelling. It involves about 1,175 adults with early memory proble…

This trial is testing whether adding an experimental anti-tau drug (E2814) to an approved anti-amyloid drug (lecanemab) can better slow the progression of Alzheimer's disease in people who have a specific genetic mutation that causes it. It involves about 200 participants, some w…

This study is testing whether a daily treatment using special light and sound stimulation can slow the progression of Alzheimer's disease. About 670 people with mild to moderate Alzheimer's will use either the active stimulation device or a look-alike sham device at home for a ye…

This study is following older adults for six years to see if using hearing aids can slow down memory loss and thinking problems, and reduce the risk of developing dementia. It builds on a previous 3-year trial and involves about 629 participants aged 70-84 who have untreated hear…

This large study is testing if a widely used medication called tranexamic acid (TXA) can prevent or reduce delirium—a serious state of sudden confusion—after major gastrointestinal surgery. It involves 826 older adults at high risk for complications, comparing the drug to a place…

This study is testing if adding a common food preservative (sodium benzoate) to a non-invasive brain stimulation treatment (tDCS) can help people in the early stages of Alzheimer's disease. It involves 140 participants with mild memory problems who will receive brain stimulation …

This study is testing whether an investigational drug called JNJ-63733657 can slow the progression of early Alzheimer's disease. The drug is an antibody designed to target and clear tau protein, one of the key abnormal proteins that builds up in the Alzheimer's brain. About 523 p…

This study is testing the drug lecanemab in people who have a genetic form of Alzheimer's disease and have already been in a related long-term trial. The main goal is to see if aggressively removing amyloid plaque from the brain years before symptoms typically appear can signific…

This study is testing whether nicorandil, an existing heart medication, is safe and might help slow brain shrinkage in older adults with a dementia type often mistaken for Alzheimer's. It will involve 64 participants aged 75+ who have this specific brain condition. The goal is to…

This study aims to see if a special brain scan called DaTSCAN can help doctors better understand and diagnose conditions like dementia, Parkinson's disease, and mild memory problems. Researchers will scan 500 adults aged 40-90 who have one of these conditions and compare the scan…

This study is testing a new, quick iPad-based tool called ToolboxDetect to help primary care doctors spot early signs of memory and thinking problems in older adults during their annual wellness visits. It aims to see if this 7-8 minute test is better than usual care at finding c…

This study is testing a personalized website called 'Small Steps' that helps older adults make lifestyle changes to reduce their risk of developing dementia. Participants aged 65 and over use the website to plan small, manageable changes to sit less, move more, and improve their …

This study aimed to test a tracking device called Care Companion, designed to help family caregivers monitor loved ones with dementia who are at risk of wandering away. The research planned to first check if the system was practical to use, then measure if it actually reduced car…

This study is testing whether a special training program for caregivers makes a visual mapping technology more helpful for people with Alzheimer's or other dementias. The technology uses picture-based schedules to help with daily tasks and independence. Researchers want to see if…

This small pilot study is testing whether a simple, caregiver-led nature activity program can improve wellbeing for people living with mild cognitive impairment or dementia and their family caregivers. The program involves 8 weekly sessions of guided nature activities. Researcher…

This study is testing whether a year-long support program led by a nurse can help people with dementia and their caregivers. 200 participants from a Stanford research center are randomly assigned to receive either their usual care or usual care plus monthly phone/video sessions w…

This study is testing whether a new website tool called WeCareToFeedDysphagia can help reduce stress and burden for caregivers of dementia patients who have trouble swallowing. Researchers will compare caregivers who use the website tool to those who don't, measuring their stress…

This study is testing a new home exercise program for older adults with mild memory loss or dementia. Participants use a special video game system at home to do balance and thinking exercises, which are supervised remotely by a therapist through video calls. The goal is to see if…

This study is testing whether a liquid medicine containing THC and CBD (compounds from cannabis) can reduce agitation and distress in people with advanced dementia who are eligible for hospice care. About 120 participants will take either the active medicine or a placebo for 12 w…

This study is testing a specially designed garment for elderly people with dementia who have incontinence and behavioral problems. The goal is to create a comfortable, dignified alternative to standard protective wear, which can be stressful for patients to wear and upsetting for…

This study is testing if playing motion-based games, like Wii or using an interactive 'Magic Table,' can improve mood and engagement for older adults with mild to moderate dementia. About 20 participants from a specific adult day care center will try these games and be compared t…

This study is testing whether joining a community choir can help reduce feelings of loneliness for people living with dementia at home and for the family or friends who care for them. About 100 participants will join one of five choirs, and researchers will measure loneliness, mo…

This study is testing whether a special virtual reality program can help older adults feel better and think more clearly. The program uses nostalgic scenes from Taiwanese culture to spark memories and includes brain-training games. Researchers will compare 90 older adults who try…

This Yale University study is exploring whether attending live music concerts can help reduce anxiety and improve emotional connection for people in the early stages of Alzheimer's disease and their caregivers. Researchers will measure brain activity, heart rate, and survey respo…

This study is testing a new remote therapy program designed to help reduce anxiety in people living with mild cognitive impairment or dementia. The program uses video calls and a special software platform to deliver cognitive behavioral therapy techniques. Researchers are measuri…

This study is testing whether digital brain games (on a device) or physical, hands-on puzzles and activities are better at helping older adults with mild to moderate Alzheimer's disease. It involves over 500 participants in Portugal and aims to see which type of activity best sup…

This study is testing a special group exercise program called PLIÉ for Veterans with dementia living in VA long-term care centers. The program aims to help residents improve their physical function, mood, and social engagement. Researchers are also training staff to lead these cl…

This study is testing a new program that uses augmented reality (AR) glasses or screens to guide people with early-stage dementia through calming aromatherapy activities. The goal is to see if this high-tech, hands-on approach can help reduce common symptoms like anxiety, agitati…

This study is testing whether special blends of essential oils, like lavender and orange, can help people with dementia. It aims to reduce the evening agitation known as 'sundowning' and improve sleep quality. Researchers are comparing two different oil formulas given to 35 parti…

This research aims to understand how common dementia is among older Mexican Americans compared to non-Hispanic whites in Texas. Researchers are visiting homes to track participants' cognitive health over time and examine what factors might contribute to differences between groups…

This study aims to understand why people with chronic kidney disease (CKD) often develop memory loss and thinking problems. Researchers are following 600 people, with and without CKD, for up to five years, tracking their cognitive function and taking brain scans. The goal is to i…

This study is observing over 19,000 older adults who previously participated in an aspirin trial to see if there are any delayed health effects years after stopping the medication. Researchers are primarily watching for long-term impacts on cancer, dementia, heart disease, and ph…

This study aims to understand how reduced blood flow in the brain's small vessels relates to Alzheimer's disease progression over time. Researchers will follow 120 older adults, including healthy controls and people with early memory problems, for three years using MRI scans and …

This study aims to see if new blood tests can accurately diagnose different types of dementia in real-world medical settings. Researchers will follow 3,165 people aged 45+ with memory concerns at UK memory clinics over three years. Participants will give blood samples and complet…

This study is looking back at data from a program that provided education and support to caregivers of people with dementia. Researchers will review past records and conduct follow-up interviews with about 350 caregivers to see if the program helped them feel less burdened and im…

This study aims to understand why many intensive care unit (ICU) survivors develop long-term thinking and memory problems. Researchers followed 826 adult ICU patients to see if confusion during their stay (delirium) or strong sedative medications increase the risk of these cognit…

This study aims to better understand how Alzheimer's disease develops and progresses over time. It will follow 1,500 older adults, including those with normal memory, mild memory problems, and dementia, for up to five years. Researchers will use memory tests, brain scans, and blo…

This study is testing whether an interactive virtual reality (VR) game can help train future nurses to care for people with dementia. 200 nursing students in Indonesia will try a VR simulation where they role-play with an AI character representing a person with dementia. Research…

This large observational study aims to find better ways to detect Alzheimer's and Parkinson's diseases at their earliest stages, before significant symptoms develop. Researchers will enroll up to 100,000 participants aged 45 and older, using smartphone apps and wearable devices t…

This study is evaluating a training program for volunteers who visit and support older adults with memory loss, dementia, or Alzheimer's. The program is being tested in a real-world setting by a social service organization in Minnesota. Researchers are analyzing data to see if th…

This small, early-stage study is testing whether an oral supplement called MIB-626 can reach the brain and affect biological pathways related to aging in people with mild Alzheimer's disease. Researchers will measure the supplement's levels in spinal fluid and brain scans in 22 p…

This study aims to gather feedback from patients with neurological diseases like Alzheimer's and Parkinson's about their experience using the MemorEM head device. About 1,000 patients and their caregivers will share their thoughts through monthly surveys to help improve the devic…

This study aims to find better ways for doctors to talk with seriously ill patients about their end-of-life care preferences. It will test different communication strategies with 5,000 Duke Health patients who have conditions like cancer, heart failure, COPD, or dementia. The goa…

This study aims to understand how blood tests for Alzheimer's disease work differently in men and women. Researchers will analyze blood samples from over 13,000 older adults to see if these tests predict dementia risk differently based on sex and other health factors. The goal is…

This study aims to better understand and track different types of dementia, like Alzheimer's and vascular dementia, by observing how the brain changes over time. Researchers are using yearly MRI brain scans, genetic tests, and memory assessments on nearly 2,000 participants to cr…

This study is testing whether a virtual reality (VR) education program can improve nursing students' attitudes, knowledge, and willingness to help people living with dementia. It involves 200 nursing students in Indonesia, who are randomly assigned to either try the VR program or…

This study examines whether nursing homes have been increasingly prescribing anti-seizure medications to dementia patients instead of monitored psychiatric drugs, especially during the COVID-19 pandemic. Researchers will analyze prescription records and health outcomes for millio…

This study aims to understand the experiences of healthcare support workers when responding to distressed behaviors in people with dementia. It involves six workers from a hospital ward sharing their stories. The goal is to use these insights to guide the development of better tr…

This study is testing whether a community-based education and navigation program, led by trained community health workers, can help Korean American elders with signs of dementia get connected to medical care. It also aims to see if the program improves caregivers' knowledge, conf…