Simple drug may stop Post-Surgery brain fog in High-Risk patients

NCT ID NCT05470816

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving tranexamic acid before major gastrointestinal surgery can lower the chance of delirium (sudden confusion) after the operation. Delirium is common in older or sicker patients and may be caused by inflammation harming the brain. The trial includes 826 adults with two or more risk factors, such as age 70+ or diabetes, and compares the drug to a placebo. The goal is to see if this simple, safe medication can protect brain function and improve recovery.

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Conditions

The condition(s) this trial relates to.

cognitive disorder dementia Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Alfred Health

    Melbourne, Victoria, 3181, Australia

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