A new wash could outsmart spine surgery infections without the seroma risk
NCT ID NCT06439953
First seen Aug 14, 2026 ยท Last updated Aug 14, 2026
Summary
This trial compares two ways to clean the wound during spinal instrumentation surgery to prevent surgical site infections. One method uses Irrisept, a chlorhexidine-based antiseptic rinse, while the other uses a vancomycin-saline wash, sometimes with added vancomycin powder. The study includes adults undergoing spine surgery for deformity, tumors, degeneration, or trauma, and tracks infection rates, hospital stay length, readmissions, and mortality. The goal is to see if Irrisept can lower infection risk while avoiding the fluid buildup (seroma) that topical vancomycin powder may cause.
What this could mean
Our plain-language read of the trial. This is informational only โ not medical advice or a prediction.
- Active substance
- Irrisept (chlorhexidine gluconate solution) irrigation compared with vancomycin-saline irrigation, with or without topical vancomycin powder
- What this could lead to
- If Irrisept works better, it could reduce deep spine infections after surgery and avoid the seroma risk linked to topical vancomycin powder.
- What could go wrong
- This is a single-center trial with 200 patients, so results may not apply broadly. Irrisept may not outperform vancomycin, and any irrigation method carries risks like allergic reactions or tissue irritation.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Rhode Island Hospital
RECRUITINGProvidence, Rhode Island, 02903, United States
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