A new wash could outsmart spine surgery infections without the seroma risk

NCT ID NCT06439953

First seen Aug 14, 2026 ยท Last updated Aug 14, 2026

Summary

This trial compares two ways to clean the wound during spinal instrumentation surgery to prevent surgical site infections. One method uses Irrisept, a chlorhexidine-based antiseptic rinse, while the other uses a vancomycin-saline wash, sometimes with added vancomycin powder. The study includes adults undergoing spine surgery for deformity, tumors, degeneration, or trauma, and tracks infection rates, hospital stay length, readmissions, and mortality. The goal is to see if Irrisept can lower infection risk while avoiding the fluid buildup (seroma) that topical vancomycin powder may cause.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
Irrisept (chlorhexidine gluconate solution) irrigation compared with vancomycin-saline irrigation, with or without topical vancomycin powder
What this could lead to
If Irrisept works better, it could reduce deep spine infections after surgery and avoid the seroma risk linked to topical vancomycin powder.
What could go wrong
This is a single-center trial with 200 patients, so results may not apply broadly. Irrisept may not outperform vancomycin, and any irrigation method carries risks like allergic reactions or tissue irritation.

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Conditions

The condition(s) this trial relates to.

Postoperative Complications Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Rhode Island Hospital

    RECRUITING

    Providence, Rhode Island, 02903, United States

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