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Which anesthetic keeps nerve signals clearer during spine surgery?

NCT ID NCT07718152

Knowledge-focused Sponsor: Affiliated 2 Hospital of Nantong University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This trial tests two newer intravenous anesthetics, ciprofol and remimazolam, to see which one interferes less with nerve-signal monitoring during spine surgery. Each participant receives both drugs in a random order during stable parts of the operation, allowing a direct comparison. The goal is to find the anesthetic that provides clearer signals for motor and sensory nerve monitoring, which helps surgeons avoid nerve damage.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
two newer intravenous anesthetics, ciprofol and remimazolam, given with remifentanil
What this could lead to
If one anesthetic consistently preserves nerve-signal quality better, it could become the preferred choice for spine surgeries that require monitoring, potentially reducing the risk of nerve injury.
What could go wrong
This is a small, single-center trial with only 60 participants, so results may not apply broadly. The study compares signals during stable windows, not actual surgical outcomes, so clinical benefits remain uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18 to 75 years. 2. Scheduled to undergo elective spine surgery. 3. Planned intraoperative monitoring with MEP and SEP/SSEP. 4. Expected surgical duration sufficient to complete two study drug periods and intraoperative monitoring windows, preferably at least 3.5 to 4 hours. 5. American Society of Anesthesiologists physical status I to III. 6. Able to provide written informed consent, or consent provided by a legally authorized representative where applicable. Exclusion Criteria: 1. Known allergy or contraindication to ciprofol, remimazolam, benzodiazepines, propofol-related formulations, opioids, or relevant excipients. 2. Severe preoperative motor or sensory deficit preventing interpretable target MEP or SEP baseline recordings. 3. Implanted cardiac pacemaker, skull defect, or other condition considered unsuitable for transcranial electrical stimulation. 4. Severe neuromuscular disease, poorly controlled epilepsy, severe cognitive impairment, or inability to complete postoperative neurological assessment. 5. Severe hepatic or renal dysfunction, severe hemodynamic instability, shock, or requirement for high-dose vasoactive medications before enrollment. 6. Long-term benzodiazepine, sedative-hypnotic, antiepileptic drug use, or drug/alcohol dependence that may substantially alter anesthetic response. 7. Expected need for continuous deep neuromuscular blockade during surgery, preventing valid MEP monitoring. 8. Any other condition judged by the investigators to make participation unsuitable or unsafe.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia Intraoperative neurophysiological monitoring Spine surgery

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