Which anesthetic keeps nerve signals clearer during spine surgery?

NCT ID NCT07718152

Not yet recruiting Knowledge-focused Sponsor: Affiliated 2 Hospital of Nantong University Source: ClinicalTrials.gov ↗

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This trial tests two newer intravenous anesthetics, ciprofol and remimazolam, to see which one interferes less with nerve-signal monitoring during spine surgery. Each participant receives both drugs in a random order during stable parts of the operation, allowing a direct comparison. The goal is to find the anesthetic that provides clearer signals for motor and sensory nerve monitoring, which helps surgeons avoid nerve damage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: two newer intravenous anesthetics, ciprofol and remimazolam, given with remifentanil
What this could lead to: If one anesthetic consistently preserves nerve-signal quality better, it could become the preferred choice for spine surgeries that require monitoring, potentially reducing the risk of nerve injury.
What could go wrong: This is a small, single-center trial with only 60 participants, so results may not apply broadly. The study compares signals during stable windows, not actual surgical outcomes, so clinical benefits remain uncertain.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANESTHESIA INTRAOPERATIVE NEUROPHYSIOLOGICAL MONITORING SPINE SURGERY

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