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Which blood pressure drug protects organs better during spine surgery?

NCT ID NCT07796282

Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 01, 2026 · Last updated Sep 03, 2026 · Updated 2 times

Summary

This trial compares two common medications, phenylephrine and norepinephrine, used to treat low blood pressure during complex spine surgery. The goal is to see which drug better maintains blood flow to organs during the operation and leads to fewer complications and a smoother recovery. About 50 adults scheduled for major spine fusion will receive one of the two drugs, and researchers will measure blood lactate levels as a marker of tissue health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Phenylephrine hydrochloride infusion and norepinephrine bitartrate infusion
What this could lead to
If one drug works better, it could guide safer blood pressure management during spine surgery, reducing complications and speeding recovery.
What could go wrong
This is a small, single-center trial, so results may not apply to all patients. Both drugs are standard, so the difference may be small.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Scheduled for elective complex spine surgery including posterior fusion of 5 or more levels of the thoracic and/or lumbar region. * ASA physical status classification I-III. * Able to provide informed consent. Exclusion Criteria: * Known allergies or contraindication to NE or PE. * Pregnant or breastfeeding women. * Emergency surgeries. * Persistent atrial fibrillation * LVEF \< 40% * Moderate or severe valvular dysfunction * RVSP ≥ 60 mm Hg * Liver failure or cirrhosis * eGFR \< 15 and/or on hemodialysis * Minimally invasive or endoscopic surgeries

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intraoperative hypotension Spine surgery Tissue perfusion

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Mayo Clinic

    Jacksonville, Florida, 32224, United States

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