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Which anesthetic keeps blood pressure steadier during aortic surgery?

NCT ID NCT07806006

Disease control Sponsor: Seoul National University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time

Summary

This trial tests whether the anesthetic remimazolam keeps blood pressure more stable than the standard drug propofol in adults undergoing surgery to repair an aortic aneurysm. Maintaining steady blood pressure during these procedures helps protect vital organs. Researchers will measure how much blood-pressure-supporting medication each patient needs during surgery to see which anesthetic offers better stability.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
remimazolam (an intravenous anesthetic) compared with propofol (another intravenous anesthetic)
What this could lead to
If remimazolam keeps blood pressure steadier than propofol during aortic repair, it could become the preferred anesthetic for these high-risk surgeries, reducing complications.
What could go wrong
This is a small, single-blind trial, so results may not apply broadly. Remimazolam can cause side effects like any anesthetic, and its benefit over propofol is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 44 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- Adults aged 20 years or older scheduled for thoracic or abdominal endovascular aortic repair (TEVAR/EVAR) under general anesthesia for thoracic or abdominal aortic aneurysm Exclusion Criteria: * Known or suspected allergy or hypersensitivity to the study drugs * ASA physical status class IV or higher * Body mass index (BMI) ≥ 30 kg/m\^2 * Chronic use of opioids or benzodiazepines * History of alcohol or drug abuse * Preoperative cognitive impairment * Severe left ventricular dysfunction (left ventricular ejection fraction \< 40%) * Severe hepatic dysfunction (Child-Pugh class C) * Severe hypoalbuminemia (\< 2.0 g/dL) * Acute or chronic renal failure requiring dialysis * Pregnancy or breastfeeding * Emergency procedure

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Conditions

The condition(s) this trial relates to.

abdominal aortic aneurysm aortic aneurysm Aortic Aneurysm, Thoracoabdominal

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aortic aneurysm, abdominal Aortic aneurysm, thoracoabdominal Hemodynamic instability during anesthesia Intraoperative hypotension

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Seoul National University Hospital

    Seoul, 03080, South Korea

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