Can a new anesthetic protect older Patients' blood pressure during surgery?
NCT ID NCT07808125
First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time
Summary
This study looks at whether the anesthetic ciprofol causes fewer dangerous drops in blood pressure during surgery than the standard drug propofol in older adults. Researchers will review records from 85,000 patients aged 65 and older who had non-cardiac surgery under general anesthesia. They will compare how often and how severely blood pressure falls below safe levels with each drug.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ciprofol, an anesthetic drug, compared with propofol
- What this could lead to
- If ciprofol proves safer, it could become a preferred anesthetic for older adults, reducing complications from low blood pressure during surgery.
- What could go wrong
- This is a retrospective study, not a controlled experiment, so other factors may explain the results. Also, the findings may not apply to all patients or settings.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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85,000 people
The number who actually took part.
- Started
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Jan 2013
- Finished
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Sep 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
This was a multicentre retrospective observational study of elderly patients aged 65 years or older who underwent non-cardiac surgery at three hospitals between 1 January 2013 and 1 September 2024. The analysis included surgical procedures performed under general anaesthesia in which either ciprofol alone or propofol alone was used. Procedures with missing key identifiers, uncertain general-anaesthesia status, absent event records, invalid anaesthesia times, or an anaesthesia duration of 24 hours or longer were excluded. Procedures without at least one valid intraoperative MAP measurement within the anaesthesia time window, as well as records with missing age or invalid sex information, were also excluded. Missing preoperative MAP values were not an exclusion criterion. The final analytical population comprised approximately 85,000 surgical procedures.
- Ages
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65 years and older
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Surgical procedures recorded at the three participating hospitals: NanYi, AnYi, and ZhongDa 2. Surgical procedures with a non-missing PATIENT\_ID 3. Patients who received either ciprofol alone or propofol alone during anesthesia 4. Surgical procedures performed under general anesthesia 5. Surgical procedures with a corresponding record in the anesthesia event dataset 6. Surgical procedures with valid anesthesia start and end times, including times supplemented from operation-room or event records when necessary 7. Surgical procedures with an anesthesia duration greater than 0 minutes and less than 24 hours 8. Surgical procedures with at least one valid intraoperative MAP measurement recorded within the anesthesia time window 9. Patients with available age information 10. Patients with a recorded sex of male or female Exclusion Criteria: 1. Surgical procedures with a missing PATIENT\_ID 2. Procedures involving both ciprofol and propofol, neither drug, missing drug indicators, or other invalid drug coding 3. Non-general anesthesia procedures or procedures for which the anesthesia method could not be confirmed as general anesthesia 4. Surgical procedures with both the operation department and operation name missing 5. Surgical procedures without a corresponding anesthesia event record 6. Surgical procedures with invalid anesthesia timing, including an anesthesia end time earlier than or equal to the anesthesia start time 7. Surgical procedures with an anesthesia duration of 24 hours or longer 8. Surgical procedures without any valid intraoperative MAP measurement within the anesthesia time window 9. Patients with missing age 10. Records with sex values other than male or female
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Nanjing First Hospital, Nanjing Medical University
Nanjing, Jiangsu, 210006, China
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