Can a common mineral keep spine surgery safer?

NCT ID NCT06975072

Recruiting now Knowledge-focused Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

This trial is taking on new participants right now.

First seen Aug 21, 2026 · Last updated Aug 21, 2026

Summary

This trial investigates whether a single dose of magnesium sulfate, given during spinal fusion surgery, changes the signals used to monitor nerve health. The study includes adults undergoing open thoracolumbar fusion with planned neuromonitoring. Researchers will measure magnesium levels in the blood and track how the monitoring signals respond, to see if this common pain-relieving adjunct is safe to use during these procedures.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Magnesium sulfate given as a single intravenous bolus
What this could lead to: If magnesium sulfate proves safe during nerve monitoring, it could become a standard way to reduce pain and opioid use after spinal surgery without compromising patient safety.
What could go wrong: This is a small, early-phase study with only 40 participants, so results may not apply to all patients. Magnesium can affect heart and kidney function, and its impact on monitoring signals is still uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Adult patients (\>18 years of age) undergoing open thoracolumbar fusion with planned neuromonitoring Exclusion Criteria: 1. Patients with a history of significant cardiac disease (LVEF \<35%, 2nd/3rd-degree block without a pacemaker, or significant arrhythmia) 2. Patients with kidney disease (GFR \<30), or hepatic dysfunction (history of cirrhosis) 3. Allergy or sensitivity to magnesium 4. Patient with neuromuscular disease such as myasthenia graves

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Conditions

The condition(s) this trial relates to.

Pain vertebral column disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PAIN SPINE SPINE FUSION SPINE SURGERY SPINE SURGERY WITH MOTOR EVOKED POTENTIAL MONITORING SPINE SURGERY WITH NEUROMONITORING

Contacts and locations

Locations

University of California San Francisco Hospital
RECRUITING

San Francisco, California, 94143, United States

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