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Which epidural technique best handles a cesarean emergency?

NCT ID NCT05514431

Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

Researchers at Mayo Clinic are reviewing records from 1,500 women who had an epidural for labor pain and then needed a cesarean delivery. They are comparing three epidural placement techniques: traditional epidural, dural puncture epidural (DPE), and combined spinal-epidural (CSE). The goal is to see which technique most reliably provides enough anesthesia for the cesarean surgery. This study could help doctors choose the best epidural method for laboring women.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Epidural catheter placement using one of three techniques: traditional epidural, dural puncture epidural (DPE), or combined spinal-epidural (CSE)
What this could lead to
If one technique proves more reliable for surgical anesthesia, it could guide how doctors place epidurals for labor, improving outcomes for women who need a cesarean delivery.
What could go wrong
This is a retrospective review, not a controlled experiment, so it can only show associations, not cause and effect. Results may not apply to all hospitals or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2017

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Parturients that undergo intrapartum cesarean delivery with an epidural already in situ.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Women with neuraxial labor analgesia (CSE, DPE, or Epidural) who have an intrapartum cesarean delivery 2. Singleton gestation Exclusion Criteria: 1. No local anesthetic given in epidural for cesarean delivery (in emergency situation) 2. Inadvertent dural puncture

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Conditions

The condition(s) this trial relates to.

agnosia pain agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Analgesia Anesthesia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • BC Women's Hospital

    Vancouver, British Columbia, Canada

  • Mayo Clinic

    Rochester, Minnesota, 55902, United States

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