ANESTHESIA

This study compares two standard blood pressure medications, norepinephrine and phenylephrine, given during major non-cardiac surgery to prevent acute kidney injury. About 18,000 adults having surgery lasting at least two hours will be included. Hospitals will alternate which dru…

This study compares a new compact version of a computer-controlled anesthesia delivery system to an older model. The system automatically adjusts the amount of propofol (sleep medicine) based on the patient's brain activity. Researchers will enroll 150 adults undergoing non-cardi…

This study tests three different approaches given during donor anesthesia to help the new kidney work better right after transplant. The goal is to see which method—mannitol, dopamine, or extra fluids—best improves kidney function. The study involves 60 adults with end-stage kidn…

This study compares light versus deep general anesthesia in older adults (65+ or Indigenous 55+) having major surgery. The goal is to see if lighter anesthesia reduces delirium—sudden confusion—and long-term memory problems. About 2,766 participants will be randomly assigned to o…

This study tests whether slowly increasing the dose of the anesthetic drug propofol based on a patient's needs keeps blood pressure more stable than giving a standard starting dose. Researchers will enroll 320 adults aged 55 and older having non-cardiac surgery. The goal is to se…

This study compares a combination of anesthesia methods (multimodal) to standard anesthesia for people having robotic kidney surgery for cancer. The goal is to see if the special approach helps patients recover more quickly, have less pain, and go home sooner. About 80 adults wil…

This study compares opioid-free anesthesia to standard opioid-based anesthesia in 40 adults undergoing open abdominal aortic aneurysm repair. The goal is to see if avoiding opioids reduces the body's stress response and inflammation during and after surgery. Researchers will meas…

This study compares three different drugs (dexmedetomidine, fentanyl, and magnesium sulphate) used alongside propofol anesthesia for brain surgery. The goal is to see which combination reduces the amount of propofol needed and improves patient outcomes. 108 adults undergoing elec…

This study tests whether avoiding opioids during breast cancer surgery can reduce pain and side effects afterward. About 200 adults having a lumpectomy or mastectomy will be randomly assigned to receive either opioid-free or standard anesthesia. Researchers will measure pain leve…

This study compares two ways to manage pain after total knee replacement: a single-shot nerve block versus a continuous nerve block using a small catheter. About 94 adults having knee surgery will be randomly assigned to one method. The goal is to see which approach reduces opioi…

This study tests whether the drug aprepitant can prevent nausea and vomiting in children and teens after scoliosis surgery. About 100 participants aged 8 to 18 will receive either aprepitant or standard care. The goal is to see if fewer kids need extra anti-nausea medicine after …

This study tests whether a virtual reality (VR) simulation of an MRI scan can help children aged 4-18 stay calm enough to complete the real scan without anesthesia. About 288 children will be randomly assigned to VR preparation, a booklet, or usual care. The main goal is to see i…

This study compares two numbing techniques for dental work in children aged 6 to 12: a computer-controlled injection into the jawbone (digital intraosseous) and a manual injection into the ligament around the tooth. Researchers will measure pain, heart rate, and how well the numb…

This study looks at how different strengths of the numbing drug ropivacaine affect how fast and how long an ankle block works for people having bunion surgery. About 174 adults will be randomly assigned to receive one of three concentrations. The goal is to find the best dose for…

This study tests whether adding dexmedetomidine to the standard spinal anesthetic bupivacaine improves pain relief and recovery for women undergoing planned C-sections. 300 full-term pregnant women will be randomly assigned to receive either bupivacaine alone or bupivacaine plus …

This study tests whether interventional radiologists can safely give deep sedation using ketamine, fentanyl, and midazolam for procedures that normally require general anesthesia. Up to 40 adults will participate. The main goal is to see if the procedure can be completed without …

This study compares two common medications, dexmedetomidine and dexamethasone, when added to a nerve block for arm surgery. The goal is to see which one helps the block work faster, last longer, and reduce the need for painkillers afterward. About 44 adults aged 18-70 will take p…

This study tests whether adding a special nerve block (BAP) to a standard abdominal wall block (TAP) can better control pain and reduce the need for strong painkillers after minimally invasive left-sided colorectal surgery. About 140 adults having elective laparoscopic surgery wi…

This study tests two different mixtures of common anesthesia drugs (propofol and etomidate) to see which one keeps blood pressure more stable and causes fewer side effects during endoscopy. About 200 adults with higher health risks will take part. The goal is to find a safer way …

This study compares giving methadone as a pill before heart surgery versus through an IV during surgery. Researchers want to see which method reduces pain and the amount of extra opioids needed in the days after surgery. About 100 adults having planned heart surgery will take par…

This study tests whether using epidural anesthesia (a numbing shot in the back) instead of general anesthesia (being put to sleep) can improve patient satisfaction and safety during laparoscopic kidney removal. About 80 adults scheduled for this surgery will take part. The goal i…

This study tests whether using positive language during epidural placement can lower pain scores compared to negative phrasing. Thirty pregnant women receiving their first epidural will be randomly assigned to hear either a positive or negative script. The goal is to see if the w…

This study compares two pain-block methods for people having laparoscopic colorectal surgery. Half the participants will get a standard abdominal wall block, while the other half gets that block plus an additional back block. The goal is to see if the combo reduces pain and the n…

This phase 4 trial tests whether itopride, a drug that helps move food through the stomach, can reduce the risk of aspiration during anesthesia in people taking semaglutide. Sixty diabetic patients scheduled for hysterectomy will receive itopride or a placebo for 7 days before su…

This study compares two methods of numbing the shoulder after total shoulder replacement: a continuous catheter that delivers pain medicine over time versus a single injection of long-lasting medication. About 56 adults having shoulder replacement will be randomly assigned to one…

This study tests whether labetalol or lignocaine (lidocaine) is better at preventing sudden rises in heart rate and blood pressure when a breathing tube is inserted for gallbladder surgery. 116 adults having elective laparoscopic gallbladder removal will receive one of the two dr…

This study tests a new type of nerve block, called a deep rectus sheath block, to see if it can reduce pain and the need for morphine after laparoscopic gallbladder removal. The trial will involve 60 adults aged 18 to 80 who are scheduled for this surgery. Researchers will measur…

This study tests whether a nerve block called PENG block can control pain after hip replacement as well as the usual method of injecting numbing medication into the surgical area. Sixty adults getting hip replacement will be randomly assigned to one of the two pain relief methods…

This study compares spinal anesthesia to general anesthesia in men undergoing open simple prostatectomy for an enlarged prostate. The goal is to see if spinal anesthesia leads to less postoperative bleeding, such as fewer blood transfusions or less need for bladder irrigation. Ei…

This study uses brain scans to understand how low doses of nitrous oxide (laughing gas) change the way the brain processes pain and forms memories. Sixty healthy volunteers will receive mild electric shocks while breathing nitrous oxide or normal air, and their brain activity wil…

This study looks at whether the amount of light in the room changes how much anesthesia medicine people need during surgery. 66 adults having general anesthesia will be randomly assigned to wear an eye shield or not. Researchers will measure drug doses, time to fall asleep, and t…

This study looks at whether changing the amount of carbon dioxide (CO2) in a child's breath during anesthesia affects how deeply asleep they are. Researchers will adjust CO2 levels in 100 children aged 3-11 and measure brain activity with a monitor. The goal is to see if higher C…

This study will follow 50,000 adults having planned non-cardiac surgery at two hospitals in Sweden. Researchers want to see if how much physical activity people report doing before surgery can help predict complications like infections, heart problems, or death. The goal is to fi…

This study looks at a new, less invasive way to monitor blood flow during heart ablation procedures. Doctors will use a special device to track heart function beat-by-beat. The goal is to see if this method helps improve care for 27 adult patients having heart ablation.

This study looks at how two common anesthesia drugs, ketamine and propofol, change brain activity related to memory and pain. Healthy adults aged 18-59 will have MRI scans and EEG recordings while receiving the drugs alone or together. The goal is to understand brain connectivity…

This study compares a multilingual AI chatbot (PEAR) with standard face-to-face verbal consent for explaining anesthesia risks. About 120 adults having elective surgery will participate. The goal is to see if the chatbot improves patient understanding and reduces anxiety.

This study watches how a standard dose of dexamethasone, a drug often given during surgery, changes blood sugar levels in 100 adults having non-cardiac operations. Participants wear a continuous glucose monitor for 10 days to track sugar levels more closely than finger-prick test…

This study tests whether a device called the CoreSys monitor can help reduce the body's stress response during abdominal hysterectomy. Thirty women having the surgery will be randomly assigned to standard anesthesia or anesthesia guided by the monitor. Researchers will measure st…

This study tracks how common pain and anesthesia drugs behave in the bodies of children and teens aged 0 to 18. Researchers will measure drug levels in up to 500 participants who are already receiving these medications as part of their standard care. The goal is to create better …

This study tests whether dosing the anesthetic propofol based on adjusted body weight is better than total body weight for obese patients. Using a computer-controlled system, researchers will monitor brain activity to maintain the right depth of anesthesia. The goal is to avoid o…

This study looks at whether military medics with limited experience can use the SaCoVLM™ video laryngeal mask to manage airways and perform intubation. The research has two parts: first, training on a simulator, then using the device on sedated patients having elective surgery. T…

This large clinical trial is testing whether the type of anesthesia used during lung cancer surgery affects the chances of the cancer coming back. Over 5,000 people having surgery for early-stage non-small cell lung cancer will be randomly assigned to receive either intravenous p…

This study will look at up to 1.2 million patients to see how long they fast before surgery and whether longer fasting leads to problems like nausea, low blood pressure, or kidney injury. Researchers want to find out if current fasting guidelines are too strict and might actually…

This study tests whether a new anesthesia method for heart bypass surgery is better for patients and the planet. About 116 adults having planned bypass surgery will receive either the new technique (which uses fewer drugs and a nerve block) or standard anesthesia. Researchers wil…

This study uses brain scans (fMRI) to understand how the sedative remimazolam changes brain activity, memory, and pain perception. About 60 healthy adults will receive the drug and undergo memory tests and mild pain stimulation while being scanned. The goal is to learn how the dr…

This study looks at whether combining intravenous and inhaled anesthesia helps women recover better after gynecologic surgery compared to inhaled anesthesia alone. One hundred women aged 18-65 will be randomly assigned to one of the two methods. Their recovery will be measured us…

This study aims to create a portable, radiation-free software that uses facial recognition and neck movement analysis to predict how difficult it will be to place a breathing tube during anesthesia. Researchers will enroll 1800 adults undergoing planned surgery to test the softwa…

This study observes 80 adults with and without diabetes to see how long-term blood sugar control (measured by HbA1c) affects brain oxygen levels during urologic surgery. Researchers use a special light device (NIRS) to measure brain oxygen and track recovery after surgery. The go…

This study checks whether using a brain monitor (EEG) during children's surgery affects their behavior 1-2 years later. Researchers will compare kids who had EEG-guided anesthesia to those who had standard care. The goal is to see if better anesthesia depth control reduces long-t…

This study looks at two types of anesthesia—conscious sedation and general anesthesia—used during painless stomach exams (gastroscopy) in frail patients aged 65 and older. The goal is to see which method causes fewer heart-related problems like irregular heartbeat, blood pressure…

This study aims to count every anesthesia-related activity in Catalonia over 14 days, including surgeries, ICU care, pain management, and deliveries. Over 13,000 patients will be included without restrictions. The goal is to gather data to plan future resources and staffing needs…

This study is observing 250 adults undergoing surgery to understand how heart function and blood flow change when general anesthesia is given. Researchers focus on those who develop low blood pressure after anesthesia induction. Using echocardiography and blood pressure measureme…

This study tests a special method of removing the breathing tube after abdominal surgery to prevent lung problems. It involves 270 adults at moderate or high risk of lung complications. The goal is to see if a protective extubation approach is practical and followed correctly by …

This study looks at how low levels of carbon monoxide in the blood during anesthesia affect certain proteins linked to inflammation and cell protection. Researchers will compare two types of anesthesia gas flow in 120 adults having surgery. The goal is to understand if small amou…

This small study in 12 healthy volunteers aims to see if biological sex influences how quickly people recover from a sedative called dexmedetomidine. Researchers will also test whether a brain measurement technique (TMS-EEG) can safely track brain activity during sedation without…

This study looks at whether brain activity measured before surgery can predict how much propofol (a common anesthesia drug) a person needs to reach deep anesthesia. Researchers will test 110 adults with cognitive tests and EEG scans before their operation. The goal is to make ane…

This study explores whether a person's genetic makeup influences how they recover from surgery. Researchers will track 20,000 adults having planned operations, looking at complications like nausea, vomiting, and pain. The goal is to identify genetic factors that could help predic…

This study is tracking 2000 adults who are having weight-loss (bariatric) surgery to learn what factors influence their pain and daily functioning afterward. Researchers will use patient questionnaires to measure pain, side effects, and long-term recovery. The goal is to better u…

This study explores whether analyzing a patient's exhaled breath can accurately measure the depth of anesthesia during surgery. Researchers will compare breath concentrations of two common anesthetics with standard brain wave monitoring (BIS) in 500 adults. The goal is to develop…

This study looks at how often children develop low blood sugar (hypoglycemia) after fasting before anesthesia for elective procedures. Researchers will monitor blood sugar levels in over 6,500 children aged 1 month to 18 years to find a clear definition of hypoglycemia and identi…

This study looks at 120 women having laparoscopic gynecologic surgery. It compares two ways of using a breathing machine (volume-controlled vs. pressure-controlled ventilation) to see which one better protects lung function and brain oxygen levels during surgery. The goal is to f…

This study looks at whether a non-invasive lung maneuver can help doctors predict if a child under general anesthesia will benefit from receiving fluids. The goal is to avoid giving unnecessary fluids when they won't help. The study will include 48 children having surgery at Bost…

This study tracks 180 adults having elective lower back surgery to see how often heart injury occurs within 30 days after the operation. Researchers will also identify factors that make this injury more likely. The goal is to better understand and potentially prevent heart compli…

This study looks at whether spinal anesthesia or general anesthesia leads to fewer lung complications after delayed hip fracture surgery in people aged 65 and older. Forty participants will be assigned to one of the two anesthesia types, and their lung function will be measured a…

This registry will collect detailed information from 50,000 patients who receive emergency blood transfusions during active bleeding while under anesthesia. The goal is to analyze how transfusions affect blood clotting, oxygen levels, and other vital signs. By studying this data,…