ANESTHESIA

This study aims to find the best anesthesia approach during kidney transplant surgery to help the new kidney work better right after the operation. Researchers will compare three different methods: using a drug called Mannitol, using a drug called Dopamine, or simply giving extra…

This study is testing whether specially trained radiologists can safely use a deep sedation drug called ketamine for certain imaging-guided procedures, instead of requiring full general anesthesia with an anesthesiologist. Researchers want to see if this approach works well for p…

This study aims to find the safest mix of two common anesthesia drugs, propofol and etomidate, for patients with heart or lung conditions undergoing common endoscopy procedures. Researchers will compare two different drug ratios to see which one better maintains stable blood pres…

This study aims to find the safest anesthesia method for frail patients over 65 having a painless stomach exam. Researchers will compare two common sedation approaches to see which one causes fewer heart-related problems like abnormal heart rate or blood pressure. The goal is to …

This study is testing if a specific 'open lung' technique for removing the breathing tube after abdominal surgery can reduce lung complications like pneumonia or collapsed lung. It will involve 270 adults at high risk for these problems. The main goal is to see if running this la…

This large study aims to find out which of two common blood pressure medications is better at preventing kidney and heart injuries after major surgery. It will involve 18,000 adults having long operations and compare the standard drugs norepinephrine and phenylephrine. The goal i…

This study aims to find out which of two common breathing machine settings is safer for patients undergoing gynecologic surgery. Researchers will compare how the settings affect lung pressure and brain oxygen levels in 120 patients. The goal is to reduce the risk of lung collapse…

This study aims to find a better way to predict if a child under anesthesia needs IV fluids to treat low blood pressure. Researchers will test a simple breathing maneuver on 48 children having surgery at Boston Children's Hospital. The goal is to help doctors give the right treat…

This study is testing whether using a lighter level of general anesthesia during major surgery can help protect older adults' brains. It compares 'light' anesthesia to the usual 'deep' anesthesia to see if the lighter approach reduces post-surgery confusion (delirium) and long-te…

This study compares two different anesthesia approaches for patients having minimally invasive kidney removal surgery. Researchers want to see if epidural anesthesia (numbing medication delivered to the spine) leads to better patient satisfaction and recovery compared to traditio…

This study aims to see which of two add-on drugs, dexmedetomidine or dexamethasone, works better when mixed with a standard numbing shot for arm surgery. Researchers will give the nerve block to 44 adults having upper limb surgery to see which drug helps the numbness start faster…

This study is testing if slowly increasing the dose of an anesthesia drug (propofol) based on a patient's needs leads to more stable blood pressure during surgery compared to a standard starting dose. It involves 320 patients aged 55 and older having non-heart surgery. The goal i…

This study is testing if a medication called Itopride can help empty the stomach faster in diabetic patients who take semaglutide and are having surgery. Semaglutide can slow stomach emptying, which increases the risk of complications during anesthesia. Researchers will use ultra…

This study aims to find the best way to manage pain after total shoulder replacement surgery. Researchers are comparing a single long-acting numbing injection to a temporary catheter that delivers numbing medicine for 1-2 days. The study will measure pain levels, opioid medicatio…

This study is testing a new pain management strategy for people having minimally invasive colon surgery. Researchers will compare a combination of two targeted nerve blocks against standard pain medication to see if it better reduces pain and the need for opioid drugs in the firs…

This study is comparing two different ways to manage pain after knee replacement surgery. Researchers want to see if using a continuous pain medication catheter works better than a single injection at reducing opioid painkiller use. The study involves 94 patients aged 18-65 who a…

This study aims to find out which of two common drugs works better to prevent dangerous spikes in heart rate and blood pressure when a breathing tube is placed for gallbladder surgery. Researchers will compare labetalol and lignocaine in 116 patients having this common operation.…

This study is comparing two methods to control pain after total hip replacement surgery. It will test if a newer ultrasound-guided nerve block (called a PENG block) works as well as the current standard method, which is an injection of numbing medicine during surgery. The study a…

This study is testing if giving methadone as a pill before surgery works as well as giving it through an IV during surgery to control pain afterward. It involves 100 adults having planned heart surgery. The main goal is to see which method better reduces the need for strong paink…

This study aims to find the best strength of a numbing medicine (ropivacaine) for ankle blocks in patients having bunion surgery. Researchers are comparing three different strengths to see which one starts working fastest and provides the longest-lasting pain relief after surgery…

This study is testing whether adding a drug called dexmedetomidine to standard spinal anesthesia for planned C-sections can make the pain relief last longer and improve recovery. Researchers will compare the two approaches in 300 women having elective C-sections. The main goal is…

This study is comparing two different pain management plans for children aged 3-17 having tonsil surgery. One plan uses strong opioid painkillers, while the other tries to avoid them by using different medications. The goal is to see if the opioid-free plan controls pain just as …

This study is testing a new type of nerve block to help control pain after laparoscopic gallbladder removal surgery. Researchers will compare pain levels and medication use in 60 patients who receive the new block versus standard pain control. The goal is to see if this method pr…

This study is testing whether a newer sedation drug called remimazolam works as well as the commonly used drug propofol for keeping patients comfortable during routine endoscopic procedures like colonoscopies. It will enroll 100 adults to see if the new drug is a practical option…

This study aims to find the best combination of anesthesia drugs for patients having brain tumor surgery. Researchers will compare three different drug add-ons to see which helps control pain best, keeps blood pressure stable, and allows for faster waking after surgery. The goal …

This study is testing whether the specific words a doctor uses can change how much pain a patient feels during an epidural procedure. Researchers will compare pain levels in pregnant patients who hear either a positive or a negative description right before the epidural is placed…

This study aims to see if combining two targeted nerve blocks is better than using just one for pain control after laparoscopic colon cancer surgery. Researchers will compare pain levels and pain medication use in 50 adult patients. The goal is to find the most effective method t…

This study aims to understand how often patients experience heart muscle injury after undergoing lumbar spine surgery, a type of non-heart surgery. Researchers will follow 180 adults having elective back stabilization surgery to track this complication. The main goal is to identi…

This small pilot study aims to understand if men and women wake up differently from a common anesthesia drug called dexmedetomidine. Researchers will enroll 12 healthy volunteers to measure how long it takes them to become responsive after the drug is stopped. They will also test…

This study aims to understand what affects recovery and pain after weight-loss surgery. Researchers will follow 2,000 patients for up to 5 years, collecting information on their pain levels, side effects, and how surgery impacts their daily life and quality of life. The goal is t…

This study is testing a new method to help doctors control how deeply a patient is asleep during surgery. Researchers will measure the levels of anesthetic drugs in a patient's exhaled breath in real-time and see how well this matches the patient's brain activity. The goal is to …

This study aims to understand how different levels of oxygen and anesthetic gas flow during surgery affect the body's carbon monoxide and related cell-protection signals. Researchers will compare two anesthesia techniques in 120 healthy adults having planned surgery lasting over …

This study is testing whether a new video-assisted breathing tube (SaCoVLM™) can help military medics with limited experience safely manage patients' airways. First, medics practice on mannequins, then they use the device on sedated patients during elective surgery. Researchers w…

This study aims to better understand how children and teenagers break down common anesthesia and pain medications like ketamine and morphine. Researchers will observe 460 participants under 18 who are already receiving these drugs as part of their standard medical care. By taking…

This study aims to understand why people need different amounts of anesthesia to fall asleep for surgery. Researchers will measure brain waves and thinking skills in 110 adults before their operation to see if these can predict the precise dose needed. The goal is to create a too…

This study aims to understand how two common anesthesia drugs, ketamine and propofol, affect brain activity related to memory and pain. Researchers will scan the brains of 60 healthy adults using MRI and EEG while they receive the drugs alone and in combination. The goal is to ga…

This study aims to understand how long-term blood sugar control in diabetic patients affects brain oxygen levels during surgery and recovery afterward. Researchers will observe 80 adults having planned urologic surgery, grouping them by their recent blood sugar history. They will…

This study aims to better understand and define low blood sugar (hypoglycemia) in children who must fast before elective surgery with general anesthesia. Researchers will measure blood sugar levels in over 6,500 children aged 1 month to 18 years to identify how common it is and w…

This study is checking if using a special brain monitor during a child's surgery affects their behavior in the long run. Researchers will contact 230 children 1-2 years after their surgery to see if those who had their brain activity monitored during anesthesia behave differently…

This study aims to find out if spinal anesthesia or general anesthesia leads to fewer lung problems after hip fracture surgery in older adults. It will enroll 40 patients aged 65+ whose surgery is delayed more than 48 hours. Researchers will compare oxygen levels, lung function, …

This study aims to count and understand all the work done by anesthesia doctors in Spain. Researchers will track every anesthesia procedure over two weeks to see how much the workload has grown in 20 years. The goal is to gather data to help plan future staffing and resources for…

This study is creating a large registry to collect detailed information about how patients respond to emergency blood transfusions given during active bleeding. It will enroll 50,000 patients who receive clotting products during surgery or trauma care. The goal is to analyze this…

This study uses brain scans (fMRI) to understand how a sedative drug called remimazolam affects memory, pain perception, and brain activity in healthy adults. Researchers will compare brain scans taken with and without the drug while participants perform memory tasks and experien…

This study aims to understand why some people have more complications after surgery than others. Researchers will follow 20,000 adults having planned surgery to see if factors like a person's genetics, the type of surgery, or anesthesia used are linked to problems like severe nau…

This study aims to understand how low doses of nitrous oxide (laughing gas) affect how the brain processes pain and forms memories. Researchers will use MRI brain scans on 60 healthy volunteers while they perform tasks involving mild pain, both with and without the gas. The goal …

This study aims to understand why some patients experience sudden drops in blood pressure after receiving anesthesia before surgery. Researchers will examine heart function and blood flow in 250 adults undergoing surgery with general anesthesia. The goal is to identify the mechan…