ANESTHESIA

This study compares light versus deep general anesthesia in older adults (65+ or Indigenous 55+) having major surgery. The goal is to see if lighter anesthesia reduces delirium—sudden confusion after surgery—and long-term thinking problems. About 2,766 participants will be random…

This study compares three different anesthesia approaches during kidney transplant surgery to see which one best supports the new kidney's early function. It involves 60 patients with end-stage kidney disease receiving a living-donor transplant. Researchers will measure how well …

This Swiss study is developing AI software that analyzes patients' facial features and neck movements to predict how difficult it will be to place a breathing tube during anesthesia. The software uses photos and videos taken during pre-surgery consultations to create a risk score…

This study compares two common blood pressure drugs, norepinephrine and phenylephrine, to see which one better prevents kidney injury after major non-cardiac surgery. About 18,000 adults having surgery lasting at least two hours will be included. Hospitals will switch between the…

This study compares two methods of calculating propofol doses for obese patients during surgery to see which one works better with an automated anesthesia delivery system. About 46 obese adults having surgery will take part. The goal is to find a dosing method that avoids giving …

This study compares two medications used to sedate patients during endoscopy (a procedure to look inside the body). The goal is to see if a newer drug called remimazolam works as well as or better than the standard drug propofol. About 100 adults having planned endoscopy will tak…

This study tests whether the drug aprepitant can prevent nausea and vomiting in children and teens after scoliosis surgery. About 100 participants aged 8 to 18 will receive either aprepitant or standard care. The goal is to see if fewer children need rescue anti-nausea medication…

This study tests two different numbing techniques for children getting cavities filled in their back teeth. One method uses a digital device to inject anesthetic into the bone, while the other uses a manual injection into the ligament. The goal is to see which approach causes les…

This study compares two ways to manage pain during and after laparoscopic colorectal surgery. One group gets a standard abdominal nerve block, while the other gets that block plus an additional back nerve block. The goal is to see if the combination reduces pain and the need for …

This study compares standard spinal anesthesia (bupivacaine) with a version that adds dexmedetomidine for women having planned C-sections. Researchers want to see if the combination works just as well or better, with faster recovery and fewer side effects. About 300 healthy pregn…

This study looks at two types of anesthesia—conscious sedation and general anesthesia—used during painless gastroscopy (a stomach exam) in frail adults aged 65 and older. The goal is to see which method causes fewer heart-related problems like irregular heartbeat or blood pressur…

This study tests whether giving methadone as a pill before heart surgery works better than giving it through an IV during surgery for controlling pain afterward. About 100 adults having planned heart surgery will take part. Researchers will measure how much extra pain medicine pa…

This study compares two methods of pain control after total shoulder replacement: a single injection of a long-lasting numbing medicine (Exparel) versus a small tube (catheter) that delivers numbing medicine continuously. About 56 adults having shoulder replacement will be random…

This study tests whether itopride, a drug that helps move food through the stomach, can reduce the risk of food or liquid remaining in the stomach before surgery in people taking semaglutide (a diabetes medication). The trial will enroll 60 adults aged 40-60 who are on semaglutid…

This study compares three different medicines (dexmedetomidine, fentanyl, and magnesium sulphate) given alongside standard anesthesia during brain surgery. The goal is to see which one reduces the total amount of main anesthetic needed and helps patients wake up faster for a brai…

This study compares two pain management approaches for children aged 3-17 having tonsil surgery. One uses standard opioids, the other uses non-opioid drugs to control pain and reduce side effects like nausea and agitation. The goal is to see if the opioid-sparing method works jus…

This study tests if a nerve block (PENG block) can control pain after hip replacement as well as or better than the standard method of injecting pain medicine into the surgical area. Sixty adults having hip replacement will be randomly assigned to receive one of the two pain trea…

This study tests two medicines, labetalol and lignocaine, to see which one better prevents sudden rises in heart rate and blood pressure when a breathing tube is placed for gallbladder surgery. About 116 adults having planned gallbladder removal will receive one of the drugs befo…

This study tests whether using epidural anesthesia (numbing the lower chest) instead of general anesthesia (being fully asleep) can improve patient satisfaction and reduce risks during laparoscopic kidney removal. About 80 adults scheduled for this surgery will be randomly assign…

This study tests whether adding two specific nerve blocks (BAP and TAP) to standard pain relief can lower pain and reduce the need for strong painkillers after minimally invasive left-sided colorectal surgery. About 140 adults having elective laparoscopic surgery will be randomly…

This study compares two pain-block methods for people having knee replacement surgery. One group gets a single injection, the other gets a continuous catheter that delivers numbing medicine for longer. The goal is to see which method reduces the need for opioid painkillers. About…

This study tests a new type of nerve block (deep rectus sheath block) to reduce pain after laparoscopic gallbladder removal. 60 adults having this surgery will receive the block, and researchers will measure how much morphine they need in the first 24 hours. The goal is to see if…

This study looks at whether slowly increasing the dose of the sleep medicine propofol based on each patient's needs can keep blood pressure more stable compared to a standard starting dose. It involves 320 adults aged 55 and older having planned non-cardiac surgery. The goal is t…

This study tests whether interventional radiologists can safely give deep sedation (using ketamine) for procedures that normally require general anesthesia. The goal is to see if this approach works well and is safe, with anesthesiologists on standby if needed. About 40 adults wi…

This study tests two different mixtures of common anesthesia drugs (propofol and etomidate) to see which one keeps blood pressure more stable and causes fewer side effects during endoscopy. About 200 adults with higher health risks will take part. The goal is to find a safer way …

This study compares two common medications, dexmedetomidine and dexamethasone, when added to a nerve block for arm surgery. The goal is to see which one helps the block work faster, last longer, and reduce the need for painkillers afterward. About 44 adults aged 18-70 having uppe…

This study looks at how different concentrations of the numbing drug ropivacaine affect how fast and how long an ankle block works for people having bunion (hallux valgus) repair surgery. About 174 adults will be randomly assigned to receive one of several concentrations. The goa…

This study will examine the medical records of up to 1.2 million people who had surgery or a procedure with anesthesia. Researchers want to see if the time spent fasting before surgery affects things like nausea, low blood pressure, or kidney problems. The goal is to learn if cur…

This study is a registry that will gather information from 50,000 people who receive emergency blood products during active bleeding while under anesthesia. The goal is to analyze how blood clotting and other lab values change during transfusion, and to track deaths within one mo…

This study tests a new anesthesia technique for heart bypass surgery that aims to be better for the planet and patients. About 116 adults having planned bypass surgery will either get the new 'optimized recovery' anesthesia or standard care. Researchers will compare costs, carbon…

This study aims to understand why some people experience low blood pressure after receiving general anesthesia for surgery. Researchers will monitor heart function and blood flow in 250 adults before and after anesthesia. The goal is to identify key changes that lead to this comm…

This study aims to count all the work done by anesthesia doctors in Catalonia over 14 days. It includes surgeries, intensive care, pain management, and delivery rooms. Over 13,000 patients will be included with no restrictions. The goal is to gather data to plan future staffing a…

This study looks at whether a device called CoreSys can help reduce the body's stress response during a hysterectomy (removal of the uterus). The stress response can cause inflammation and slow recovery. Thirty women having open abdominal hysterectomy will be randomly assigned to…

This study looks at 120 women having laparoscopic gynecologic surgery to see if one type of breathing machine setting (volume-controlled vs. pressure-controlled) works better for lung and brain health. Participants are placed head-down and have gas pumped into the belly, which ca…

This study is looking at whether a person's genes can help predict problems after surgery, such as nausea, vomiting, and pain. Researchers will follow 20,000 adults having surgery and collect their genetic information along with other health data. The goal is to better understand…

This study explores whether measuring chemicals in a patient's exhaled breath can accurately track how deeply they are anesthetized during surgery. Researchers will enroll 500 adults having long surgeries and compare breath readings to standard brain-wave monitoring. The goal is …

This study aims to find out how often heart injury occurs after lower back surgery and what makes some patients more at risk. Researchers will follow 180 adults for 30 days after their operation. The goal is to better understand and possibly prevent these heart complications in t…

This study looks at 110 adults having surgery to see if brain wave patterns and simple thinking tests can predict the exact amount of anesthesia needed to reach deep sleep. Researchers will measure brain activity before and during anesthesia to understand why people need differen…

This study looks at how two common anesthetics, ketamine and propofol, change brain activity, memory, and pain perception. Healthy adults aged 18-59 will have MRI brain scans and EEG recordings while receiving these drugs alone or together. The goal is to understand how these dru…

This study tests a specific method for removing breathing tubes after abdominal surgery to prevent lung collapse and other breathing problems. It involves 270 adults at moderate to high risk for lung complications. The goal is to see if a careful, step-by-step extubation process …

This study looks at whether the type of anesthesia used during lung cancer surgery can influence whether the cancer comes back. About 5,384 people having surgery for early-stage non-small cell lung cancer will be randomly assigned to receive either inhaled gas anesthesia or intra…

This study looks at whether military medics who have little experience with intubation can safely use a special video laryngeal mask called SaCoVLM™. The study has two parts: first, training on a simulator, then using the device on sedated patients having elective surgery. The go…

This study looks at whether the way doctors describe an epidural procedure can change how much pain a person feels. Researchers will compare positive phrasing (like "you may feel pressure") with negative phrasing (like "you may feel a sharp sting") in 30 pregnant women getting th…

This study looks at whether a non-invasive lung maneuver can help doctors know if a child under general anesthesia needs fluids for low blood pressure. About 48 children having surgery at Boston Children's Hospital will take part. The goal is to avoid unnecessary treatments and i…

This study looks at children who must fast before surgery to see how often they develop low blood sugar (hypoglycemia). Researchers will track blood sugar levels in up to 6,580 children aged 1 month to 18 years during anesthesia. The goal is to find a clear definition of hypoglyc…

This study follows 2000 adults who are having weight-loss surgery to learn how pain, pain medicines, and side effects affect their daily lives. Researchers will ask patients about their pain before and after surgery using simple questionnaires. The goal is to find out what leads …

This study looks at whether spinal anesthesia or general anesthesia leads to fewer lung problems after hip surgery in older adults (65+) whose surgery was delayed. Researchers will measure oxygen levels and lung function in 40 participants. The goal is to help doctors choose the …

This study tests a new, compact version of a computer-controlled anesthesia delivery system that automatically adjusts medicine based on brain activity. It involves 150 adults having non-cardiac surgery to see if the new system keeps anesthesia depth more stable than the older ve…

This study looks at whether the amount of light in the operating room changes how much anesthesia medicine people need during surgery. About 66 adults having general anesthesia will be randomly assigned to either wear an eye shield or not. Researchers will measure drug doses, how…

This study looks at how low levels of carbon monoxide in the blood during anesthesia affect certain proteins linked to inflammation and cell health. Researchers will compare two types of anesthesia gas flow in 120 adults having surgery. The goal is to understand if small amounts …

This study looks at how well-controlled blood sugar (measured by HbA1c) affects brain oxygen levels during surgery in people with diabetes. About 80 adults having urologic surgery will be monitored with a special brain oxygen sensor. The goal is to understand the relationship, no…

This study looks at how anesthetics and pain medicines are processed in the bodies of children and teenagers (up to age 18). The goal is to understand how these drugs work in young people to help doctors give safer and more effective doses. The study is currently enrolling 500 pa…

This study uses brain scans (fMRI) to understand how the sedative remimazolam changes brain activity, memory, and pain perception. About 60 healthy adults will receive the drug and undergo memory tests and mild pain stimulation while in the scanner. The goal is to learn how the d…

This study looks at how a low dose of nitrous oxide (laughing gas) affects the brain's response to pain and memory. Healthy volunteers will have brain scans while receiving mild pain stimulation, both with and without the gas. The goal is to understand which brain areas are invol…

This study looks at whether using a special brain monitor during children's surgery can help prevent behavior problems up to two years later. Researchers will compare kids who had brain-guided anesthesia with those who had standard care. About 230 children aged 3-10 who had surge…

This study looks at whether using a mix of intravenous and inhaled anesthesia helps women recover better after gynecologic surgery compared to inhaled anesthesia alone. About 100 women aged 18 to 65 will take a survey about their recovery before and after surgery. The goal is to …

This small pilot study aims to understand if men and women wake up differently from a common anesthesia drug called dexmedetomidine. Researchers will recruit 12 healthy volunteers to measure how long it takes them to become responsive after the drug is stopped. They will also tes…