Could a simple pill before heart surgery ease pain and cut opioid use?
NCT ID NCT07221617
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares giving methadone as a pill before heart surgery versus through an IV during surgery. Researchers want to see which method reduces pain and the amount of extra opioids needed in the days after surgery. About 100 adults having planned heart surgery will take part. The goal is to find a better way to manage post-surgery pain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Methadone
What this could lead to
If it works, this could give doctors a simpler, effective way to manage pain after heart surgery and reduce the need for other opioids.
What could go wrong
This is a small, early-phase study (100 people) comparing two forms of the same drug, so any benefit may be modest. Methadone can cause side effects like slow breathing or heart rhythm changes.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Mayo Clinic in Rochester
RECRUITINGRochester, Minnesota, 55905, United States
Contact Phone: •••-•••-••••
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