Could a simple pill before heart surgery ease pain and cut opioid use?

NCT ID NCT07221617

Recruiting now Symptom relief Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares giving methadone as a pill before heart surgery versus through an IV during surgery. Researchers want to see which method reduces pain and the amount of extra opioids needed in the days after surgery. About 100 adults having planned heart surgery will take part. The goal is to find a better way to manage post-surgery pain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Methadone
What this could lead to: If it works, this could give doctors a simpler, effective way to manage pain after heart surgery and reduce the need for other opioids.
What could go wrong: This is a small, early-phase study (100 people) comparing two forms of the same drug, so any benefit may be modest. Methadone can cause side effects like slow breathing or heart rhythm changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANESTHESIA CARDIAC SURGERY PAIN, POSTOPERATIVE

Contacts and locations

Locations

Mayo Clinic in Rochester
RECRUITING

Rochester, Minnesota, 55905, United States

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