Can a simple pill speed up knee replacement recovery?
NCT ID NCT06618820
First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether taking tranexamic acid (TXA) by mouth for an extended period after total knee replacement can improve recovery. TXA is already used during surgery to reduce bleeding, but its benefits when continued afterward are unclear. The study will compare different durations of extended oral TXA against a placebo in 120 adults undergoing knee replacement, measuring pain, range of motion, and how much patients notice their knee in daily activities.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tranexamic acid (TXA) taken orally as extended-release capsules after knee replacement surgery
- What this could lead to
- If effective, extended oral TXA could become a standard part of recovery after knee replacement, helping patients regain function faster and with less pain.
- What could go wrong
- This is a single-center trial with 120 participants, and results may not apply to all patients. TXA can increase the risk of blood clots, though the trial excludes high-risk individuals.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Campbell Clinic
Germantown, Tennessee, 38138, United States
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