ANESTHESIA

This trial compares two medications—remifentanil and nicardipine—given during nasal surgery to lower blood pressure and reduce bleeding. Both are already used in practice, but it is unclear which provides a better surgical view and fewer side effects. The study includes adults un…

This trial compares two ways to lower blood pressure on purpose during ear, nose, and throat surgery. One uses only remifentanil, a fast-acting opioid; the other adds nicardipine, a drug that widens blood vessels. The goal is to see which approach gives surgeons a clearer view an…

This study compares two drugs, vasopressin and norepinephrine, given during and after surgery to remove chronic blood clots from the lungs. The goal is to see which drug better controls blood pressure in the lungs without harming the rest of the body. About 90 adults scheduled fo…

This study compares two ways of giving fluids to patients in the intensive care unit after major surgery. One group gets fluids based on a daily body scan that measures water inside and outside cells, while the other group gets fluids based on standard checks like blood pressure …

This trial tests whether oliceridine, a newer opioid, causes less coughing than the standard drug sufentanil when given at the start of general anesthesia. Coughing during this phase can be dangerous, especially for patients with high pressure in the head or eyes. The study invol…

This early study tests whether a liquid sedative called dexmedetomidine, given by mouth, can safely and effectively sedate children aged 3 to 6 for MRI scans. Currently, many young children need general anesthesia for MRI, which carries risks and requires needles. The trial will …

This study tests whether giving patients a QR code that links to a video about anesthesia can lower their anxiety before elective surgery. About 284 adults scheduled for surgery will either receive standard information alone or standard information plus the video. Researchers wil…

This study tests whether an AI-powered app can improve follow-up for patients recovering from surgery with a continuous nerve block for pain. 166 adults will use either the AI app or a standard automated messaging system. The goal is to see if the AI reduces the number of times p…

This study looks at whether drawing different colors and shapes can help calm adults who are anxious while waiting for surgery. About 175 people scheduled for elective surgery will participate. Researchers will measure their anxiety levels before and after the drawing activity to…

This study tests whether applying mild electrical stimulation to specific acupoints on the wrist before anesthesia can prevent low blood pressure in older adults undergoing surgery. Researchers will compare high-frequency versus low-frequency stimulation in 84 participants aged 6…

This study tests two different freezing medications given in the spine for knee replacement surgery. The goal is to see which one lets patients move their legs and leave the hospital faster. 170 adults having outpatient knee replacement will take part.

This study tests whether a new drug combination (anricofen plus ciprofol) can provide safer deep sedation for elderly patients undergoing ERCP, a procedure to treat bile duct problems. The goal is to reduce breathing complications and speed up recovery compared to the standard se…

This study compares a newer anesthesia drug, remimazolam, with the standard drug propofol (both combined with a painkiller) for people having chest surgery. The goal is to see if remimazolam causes fewer problems like low oxygen levels or low blood pressure during the operation. …

This study tests whether gentle electrical stimulation on acupoints can reduce stomach acid backing up into the throat during general anesthesia with an i-gel breathing tube. About 116 adults having surgery will be randomly assigned to receive the stimulation or no stimulation. T…

This study tests whether an ultrasound-guided retrolaminar block (a numbing injection near the spine) can lower the amount of opioids patients need after lumbar spine fusion surgery. Forty-four adults will be randomly assigned to receive either the active block or a sham injectio…

This study tests a new device called SafeLM™, a video-equipped breathing mask for children during surgery. Researchers want to see how easy it is to place, how well it seals the airway, and if it causes any problems. About 60 children aged up to 18 who need general anesthesia wil…

This study will look at data from 918 adults who had planned heart surgery to find out why some develop atrial fibrillation, a common and serious irregular heartbeat. The researchers will also examine whether newer anesthesia methods, like a nerve block, might help protect agains…

This study tests whether using a brain oxygen monitor to guide oxygen levels during lung surgery can reduce harm from too much oxygen. Sixty adults having elective lung surgery will be randomly assigned to either standard high oxygen or a lower oxygen strategy guided by brain oxy…

This observational study will follow 200 adults with Brugada Syndrome who need anesthesia for surgery or other procedures. Researchers want to see how often dangerous heart rhythms occur during and up to 30 days after anesthesia. They will also check if certain anesthetic drugs o…

This study watches how children aged 2 to 12 transition from inhaled anesthesia to intravenous anesthesia during surgery. Doctors use a brain-wave monitor (BIS) to guide the switch and track how much medication is needed. The goal is to better understand the process and improve s…

This study looks at how multitasking impacts the performance of anesthesiologists during a simulated medical scenario. Researchers will test 35 anesthesia doctors and residents to see how well they handle multiple tasks at once. The goal is to better understand how multitasking a…

This study will give 120 surgery patients one of three anesthetics—propofol, dexmedetomidine, or esketamine—and use high-density EEG to measure brain activity while they are unconscious. The goal is to understand how each drug disrupts brain communication and to find markers that…

This study compares a new visual bronchial blocker (with a tiny camera) to the standard blind method for placing a breathing tube during lung surgery. About 652 adults having lung, esophagus, or chest surgery will take part. The goal is to see if the camera-guided tool improves f…

This study will measure how much sevoflurane (an anesthesia gas) is used when ventilators are set to a very low fresh gas flow of 0.3 L/min. Researchers want to see if this ultra-low flow saves resources without affecting patient care. Data from 30 adult surgery patients will be …

This study will monitor the brain activity of 64 full-term newborns receiving propofol anesthesia for surgery. Researchers aim to identify specific brain wave patterns that show how deeply sedated the baby is. The goal is to improve anesthesia monitoring for this vulnerable group…

This study tests whether a machine-learning tool built into electronic health records can help doctors reduce kidney injury after surgery. Over 25,000 adults having non-emergency surgery will take part. Doctors are randomly assigned to see the tool's risk prediction, see it with …

This study watches brain activity in 300 adults during high-risk surgeries like heart or spine operations. Researchers use special monitors to track brain waves and pressure, linking them to patient outcomes. The goal is to understand why some people develop confusion or brain in…

This study looks at why some older people experience confusion or memory problems after major surgery. Researchers will test 40 patients aged 70 and older before and after colorectal or urological surgery. They will use memory tests and blood samples to see if they can link chang…

This study looks at 128 adults having gallbladder surgery to see if using a low-flow (more eco-friendly) versus normal-flow sevoflurane anesthesia changes heart electrical signals linked to dangerous rhythms. Researchers will measure these signals before, during, and after surger…

This study surveys 200 healthcare professionals (doctors, nurses, and students) about how they remove breathing tubes after a patient has been on a ventilator. The goal is to describe which techniques are used most often, especially the use of positive pressure during removal. Th…

This study will compare the quality of pre-anesthesia consultations done by video call versus in-person for pregnant women. 250 participants will be randomly assigned to one of the two methods. The main goal is to see if the video consultation misses any important safety informat…

This observational study in Danish public hospitals will survey 1,000 patients about their experiences before anaesthesia. Researchers want to learn what matters to patients and how well current consultations address their needs. The goal is to improve person-centred care by unde…

This study tests a computer program that learns from patient data to predict how the body will respond during anesthesia. Researchers will check if the AI can accurately forecast changes in brain activity and vital signs. 115 adults having planned surgery will take part. The goal…

This study looks at two different gas flow levels (low vs. minimal) for the anesthesia drug sevoflurane during robot-assisted prostate cancer surgery. The goal is to see which flow rate better maintains healthy breathing and oxygen levels during the procedure. About 70 men having…

This study tests whether adding visual aids to the standard written consent form helps patients better understand anesthesia procedures and risks. About 236 adults scheduled for surgery will be randomly assigned to receive either the usual consent form or one with extra pictures.…

This observational study will monitor brain activity (EEG) in 330 people during anesthesia or sedation to see how it relates to drug levels and patient factors. It includes children with and without autism, adults over 70, and adults having sedation for endoscopy. The goal is to …

This study looks at two ways of giving fluids during liver surgery: one that limits fluids and one that gives more. The goal is to see which approach leads to fewer serious problems after surgery, especially kidney injury. About 90 adults having planned liver surgery will take pa…

This study will test a new device called SaCo VLMA that helps patients breathe during laparoscopic surgery under general anesthesia. Researchers will compare it to other airway devices in 20 adults having short elective surgeries. They will measure how easy it is to place, how we…

This study looks at how general anesthesia affects certain brain chemicals and thinking skills. Researchers will compare 160 adults having gallbladder surgery: those who have never had anesthesia before and those who have had it multiple times. The goal is to understand if repeat…

This study is about translating and testing a questionnaire called QoR-15 for Romanian-speaking patients. The questionnaire measures how well people recover after surgery and anesthesia. Researchers will ask 250 adults to fill it out to make sure it works correctly in Romanian. T…

This study looks back at medical records of 300 adults who had a minor amputation (at or below the ankle) to see if the type of anesthesia used affects their recovery. Early data suggests that using a nerve block instead of general anesthesia may lead to fewer complications and a…

This observational study will collect data from 15,000 heart surgery patients across many hospitals worldwide. Researchers will look at how anesthesia, heart-lung machines, and surgical techniques are used, and track patient outcomes like recovery time and complications. The goal…

This study looks at whether lidocaine, a numbing medicine, changes the signals used to monitor nerves during spine surgery. 44 adults having spine surgery will get either lidocaine or a placebo. The goal is to see if lidocaine affects the nerve monitor readings, which could help …