ANESTHESIA

This study compares light versus deep general anesthesia in older adults (65+ or Indigenous 55+) having major surgery. The goal is to see if lighter anesthesia reduces delirium—a common, serious complication that can cause confusion and long-term brain decline. About 2,766 partic…

This study compares three different anesthesia approaches during kidney transplant surgery to see which one best supports the new kidney's early function. It involves 60 patients with end-stage kidney disease receiving a living-donor transplant. Researchers will measure how well …

This study compares two common blood pressure medications, norepinephrine and phenylephrine, given during major surgery to prevent kidney injury afterward. About 18,000 adults having non-cardiac surgery lasting at least two hours will be included. Hospitals will switch between th…

This study compares two medications, dexmedetomidine and dexamethasone, added to a standard nerve block for arm surgery. The goal is to see which one helps the block work faster, last longer, and reduce the need for painkillers afterward. About 44 adults aged 18-70 having upper l…

This study compares giving oral methadone before heart surgery versus intravenous methadone during anesthesia to see which better controls post-surgery pain. About 100 adults having elective cardiac surgery will participate. The goal is to reduce the total amount of opioids neede…

This study tests whether the drug aprepitant can prevent nausea and vomiting in children and teens after scoliosis surgery. About 100 participants aged 8 to 18 will receive either aprepitant or standard care. The goal is to see if fewer kids need rescue anti-nausea medication aft…

This study looks at two different numbing methods for children getting cavities filled in their back teeth. One method uses a digital device to inject numbing medicine into the bone, while the other uses a manual injection into the gum. The goal is to see which method causes less…

This study compares two ways to manage pain in children aged 3-17 having tonsil surgery. One uses standard opioids, the other uses a non-opioid drug combo. The goal is to see if the opioid-free approach controls pain just as well while reducing side effects like nausea and agitat…

This study compares a new compact version of a computer-controlled anesthesia delivery system to an older version. The goal is to see if the new system keeps patients at the right depth of anesthesia more consistently during surgery. About 150 adults having non-cardiac surgery wi…

This study looks at whether slowly increasing the dose of the sleep medicine propofol based on each patient's needs can keep blood pressure more stable than the usual one-size-fits-all starting dose. It involves 320 adults aged 55 and older having planned non-heart surgery. The g…

This study tests whether a virtual reality simulation that mimics an MRI scan can help children aged 4-18 stay calm enough to complete the real scan without anesthesia. About 288 children will either use the VR prep, read a booklet, or receive usual care before their MRI. The mai…

This study looks at how different strengths of the numbing medicine ropivacaine affect how fast and how long ankle blocks work for people having bunion surgery. About 174 adults will be randomly assigned to receive one of three concentrations. The goal is to find the best strengt…

This study compares two ways to manage pain after laparoscopic colorectal surgery. One group gets a standard abdominal nerve block, and the other gets that block plus an additional sacral block. The goal is to see which approach reduces pain and the need for strong painkillers. A…

This study tests two common medicines, labetalol and lignocaine, to see which one better prevents sudden increases in heart rate and blood pressure when a breathing tube is placed during gallbladder surgery. About 116 adults having planned gallbladder removal will take part. The …

This study compares two medications used to sedate patients during endoscopy (a procedure to look inside the body). The goal is to see if a newer drug called remimazolam works as well as or better than the standard drug propofol. About 100 adults having planned endoscopy will tak…

This study looks at 100 women having gynecologic surgery to see if a mix of intravenous and inhaled anesthesia helps them recover better than inhaled anesthesia alone. Recovery is measured using a questionnaire about pain, comfort, and daily activities. The goal is to find which …

This study tests whether using epidural anesthesia instead of general anesthesia can improve patient satisfaction and reduce complications during laparoscopic kidney removal. About 80 adults scheduled for this surgery will be randomly assigned to one of the two anesthesia methods…

This study tests if a nerve block (PENG block) works as well as the usual painkiller injection for hip replacement surgery. About 60 adults getting hip replacement will be randomly assigned to one of the two pain relief methods. Researchers will measure pain levels and muscle str…

This study tests a new type of nerve block, called a deep rectus sheath block, to see if it reduces pain after laparoscopic gallbladder removal. Sixty adults having this surgery will receive the block, and researchers will measure how much morphine they need in the first 24 hours…

This study tests whether avoiding opioids during breast cancer surgery can reduce side effects like nausea and breathing problems, while still controlling pain. About 200 adults having a lumpectomy or mastectomy will be randomly assigned to receive either opioid-free or standard …

This study tests two different mixtures of common anesthesia drugs (propofol and etomidate) to see which one keeps blood pressure more stable and causes fewer side effects during endoscopy. About 200 adults with higher health risks will take part. The goal is to find a safer way …

This study tests whether adding two targeted nerve blocks (one around the colon and one in the belly wall) to standard pain relief can lower pain and the need for strong painkillers after minimally invasive left-sided colon cancer surgery. About 140 adults having elective laparos…

This study tests whether itopride, a drug that helps the stomach empty faster, can reduce the risk of food or liquid staying in the stomach after 8 hours of fasting in people taking semaglutide. The trial involves 60 diabetic patients scheduled for hysterectomy. Researchers will …

This study compares two pain-relief methods for total knee replacement: a single injection versus a continuous catheter that delivers numbing medicine. About 94 adults having knee surgery will be randomly assigned to one of the two groups. The goal is to see which approach reduce…

This study compares standard spinal anesthesia (bupivacaine) with a combination that includes dexmedetomidine for women having planned C-sections. The goal is to see if the added drug improves pain relief and recovery without extra risks. About 300 full-term pregnant women aged 2…

This study compares two methods of calculating propofol doses for obese patients during surgery to see which one works better with an automated anesthesia delivery system. About 46 obese adults having surgery will take part. The goal is to find a dosing method that avoids giving …

This study looks at two types of anesthesia—conscious sedation and general anesthesia—used during painless gastroscopy (a stomach exam) in frail adults aged 65 and older. The goal is to see which method causes fewer heart-related problems like irregular heartbeat or blood pressur…

This study compares two methods of pain control after total shoulder replacement: a single injection of a long-lasting numbing medicine (Exparel) versus a small tube (catheter) that delivers numbing medicine continuously. About 56 adults having shoulder replacement will be random…

This study compares three different medicines (dexmedetomidine, fentanyl, and magnesium sulphate) given alongside standard anesthesia during brain surgery. The goal is to see which one reduces the total amount of main anesthetic needed and helps patients wake up faster for a brai…

This study tests whether interventional radiologists can safely give deep sedation (using ketamine) for procedures that normally require general anesthesia. The goal is to see if this approach works well and is safe, with anesthesiologists on standby if needed. About 40 adults wi…

This study looks at 120 women having laparoscopic gynecologic surgery. It compares two ways of using the breathing machine (volume-controlled vs. pressure-controlled) to see which one better protects lung function and brain oxygen levels during surgery. The goal is to find the sa…

This study watches how a standard dose of dexamethasone, a drug often given during surgery, changes blood sugar levels in 100 adults having non-cardiac surgery. Participants wear a continuous glucose monitor for 10 days after surgery, and their blood sugar is also checked with fi…

This study aims to find out how often heart injury occurs after non-cardiac lumbar surgery and what factors increase that risk. Researchers will follow 180 adults undergoing elective lumbar stabilization surgery for 30 days. The goal is to better understand and identify risk fact…

This study is a large registry that will collect information from up to 50,000 people who receive emergency blood transfusions during active bleeding. The goal is to analyze how transfusions affect blood clotting and other key health measures. By understanding these patterns, res…

This study uses brain scans (fMRI) to understand how low doses of nitrous oxide (laughing gas) affect the way the brain processes pain and forms memories. Healthy volunteers will have their brain activity measured while receiving mild pain stimulation, both with and without the g…

This study follows 2000 adults who are having weight-loss surgery to see how their pain and daily activities change afterward. Researchers will ask patients about their pain levels, side effects, and how much pain interferes with normal life. The goal is to find out what factors …

This study looks at children aged 1 month to 18 years who are fasting before planned surgery with anesthesia. The goal is to find out how often low blood sugar (hypoglycemia) happens and what blood sugar level should trigger treatment. Researchers will measure blood sugar during …

This pilot study in 12 healthy volunteers aims to see if biological sex influences how quickly people recover from unconsciousness caused by the sedative dexmedetomidine. Researchers will also test if a brain measurement technique called TMS-EEG can safely track brain activity du…

This study aims to create a portable, radiation-free software that uses facial recognition and neck movement analysis to predict how difficult it will be to place a breathing tube during anesthesia. Researchers will test the software on 1,800 adults undergoing planned surgery. Th…

This study examines how long patients fast before surgery and whether that affects their recovery. Researchers will track 1.2 million people to see if longer fasting leads to problems like nausea, low blood pressure, or kidney injury. The goal is to improve fasting guidelines for…

This study looks at how two common anesthesia drugs, ketamine and propofol, change brain activity related to memory and pain. Researchers will use MRI and EEG to scan the brains of 60 healthy adults while they receive the drugs alone or together. The goal is to understand how the…

This study looks at how well blood sugar is controlled in people with diabetes and how it affects brain oxygen levels during surgery. Researchers will use a special light device to measure brain oxygen and track recovery after surgery. The goal is to understand if better blood su…

This study tests a new method to monitor how deep a patient is under anesthesia during surgery. Instead of using standard monitors, researchers will analyze chemicals in the patient's exhaled breath to predict anesthesia depth. The goal is to find a non-invasive way to manage ane…

This study looks at how the body processes anesthetics and painkillers in children and teenagers up to age 18. By measuring drug levels in the blood, researchers hope to find the right doses for safer and more effective pain control. The study is currently recruiting 500 particip…

This study follows up with children 1-2 years after surgery to see if using a brain monitor (EEG) during anesthesia affects their long-term behavior. Researchers will compare kids who had EEG-guided anesthesia with those who had standard care. The goal is to understand if better …

This study tests a new anesthesia technique for heart bypass surgery that aims to be better for patients, cheaper, and kinder to the environment. About 116 adults having planned bypass surgery will be split into two groups: one gets the new 'optimized recovery' anesthesia, the ot…

This study uses brain scans (fMRI) to understand how the sedative remimazolam affects memory, pain perception, and brain activity. About 60 healthy adults will receive the drug and then perform memory tasks while experiencing mild pain. The goal is to learn more about how the dru…

This study looks at whether the type of anesthesia given during lung cancer surgery can influence whether the cancer comes back. About 5,384 people having surgery to remove non-small cell lung cancer will be randomly assigned to receive either inhaled gas anesthesia or intravenou…

This study tests whether a device called CoreSys can help doctors manage stress during abdominal hysterectomy. The monitor tracks consciousness, pain, and stress levels during surgery. 30 women having the procedure will be split into two groups: one with standard anesthesia care,…

This study explores whether a person's genetic makeup influences how they recover from surgery. Researchers will track 20,000 adults having planned operations, looking at complications like nausea, vomiting, and pain. The goal is to identify genetic factors that could help predic…

This study aims to count all the work done by anesthesiologists in Catalonia over 14 days. By tracking activity in operating rooms, ICUs, pain clinics, and delivery rooms, researchers hope to see if resources match the workload. Over 13,600 patients will be included, with no rest…

This study looks at whether the way doctors describe an epidural procedure can change how much pain a person feels. Researchers will compare positive versus negative phrasing in 30 pregnant women getting their first epidural. The goal is to see if positive words can lower pain sc…

This study looks at whether the amount of light in the operating room changes how much anesthesia medicine people need during surgery. 66 adults having general anesthesia will be randomly assigned to wear an eye shield or not. Researchers will measure drug doses, time to fall asl…

This study looks at whether spinal anesthesia or general anesthesia leads to fewer lung problems after hip surgery in older adults. It involves 40 people aged 65 and older who have waited more than 48 hours for surgery. Researchers will measure oxygen levels and lung function to …

This study looks at 110 adults having surgery to see if brain wave patterns and simple thinking tests can predict the exact amount of anesthesia needed to reach deep sleep. Researchers will measure brain activity before and during anesthesia to understand why people need differen…

This study tests a specific method for removing breathing tubes after abdominal surgery to prevent lung collapse and other breathing problems. It involves 270 adults at moderate to high risk for lung complications. The goal is to see if a careful, step-by-step extubation process …

This study tests whether a multilingual AI chatbot called PEAR helps patients understand anesthesia risks better than the usual face-to-face talk with a doctor. About 120 adults having planned surgery will take part. The goal is to see if the chatbot improves understanding and re…

This study aims to understand why some people experience low blood pressure after receiving general anesthesia for surgery. Researchers will monitor heart function and blood flow in 250 adults before and after anesthesia. The goal is to identify key changes that lead to this comm…

This study looks at whether military medics who have little experience with intubation can safely use a special video laryngeal mask called SaCoVLM™. The study has two parts: first, training on a simulator, then using the device on sedated patients having elective surgery. The go…

This study looks at whether a non-invasive lung maneuver can help doctors know if a child under general anesthesia needs fluids for low blood pressure. About 48 children having surgery at Boston Children's Hospital will take part. The goal is to avoid unnecessary treatments and i…

This study looks at how low levels of carbon monoxide in the blood during anesthesia affect certain proteins linked to inflammation and cell health. Researchers will compare two types of anesthesia gas flow in 120 adults having surgery. The goal is to understand if small amounts …