Kids' drug dosing mystery: new study aims to crack the code

NCT ID NCT03427736

Recruiting now Knowledge-focused Sponsor: Chi Dang Hornik Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 06, 2026 · Updated 3 times

Summary

This study tracks how common pain and anesthesia drugs behave in the bodies of children and teens aged 0 to 18. Researchers will measure drug levels in up to 500 participants who are already receiving these medications as part of their standard care. The goal is to create better dosing guidelines tailored to young patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ketorolac, Hydromorphone, Ketamine, Oxycodone, Morphine
What this could lead to: If successful, this could lead to safer, more effective dosing guidelines for pain and anesthesia drugs in children.
What could go wrong: This is an observational study, not a treatment trial. It only measures drug levels, so it won't directly improve care for participants.

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Conditions

The condition(s) this trial relates to.

Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANESTHESIA PAIN

Contacts and locations

Locations

Alfred I. DuPont Hospital for Children
ACTIVE_NOT_RECRUITING

Wilmington, Delaware, 19803, United States
Ann and Robert H. Lurie Childrens Hospital of Chicago
RECRUITING

Chicago, Illinois, 60611, United States
Baylor College of Medicine
WITHDRAWN

Houston, Texas, 77030, United States
Cardinal Glennon Children's Hospital
ACTIVE_NOT_RECRUITING

St Louis, Missouri, 63104, United States
Children's Hospital Colorado
TERMINATED

Aurora, Colorado, 80045, United States
Dell Children's Medical Center of Texas
WITHDRAWN

Austin, Texas, 78723, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27701, United States
Hospital Sainte-Justine
ACTIVE_NOT_RECRUITING

Montreal, Quebec, T3T 1C5, Canada
Lucile Packard Children's Hospital
RECRUITING

Stanford, California, 94305, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Oregon Health and Science University
ACTIVE_NOT_RECRUITING

Portland, Oregon, 97239, United States
The Hospital for Sick Children
RECRUITING

Toronto, Ontario, M5G 1X8, Canada
Washington University School of Medicine
ACTIVE_NOT_RECRUITING

St Louis, Missouri, 63110, United States

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