ANESTHESIA

This large international trial tested whether keeping a patient's blood flow (cardiac index) at their own personal baseline during major abdominal surgery reduces serious complications. Over 1,100 high-risk adults aged 45 and older took part. The goal was to see if this personali…

This study compared two medications, norepinephrine and phenylephrine, given continuously during C-sections to prevent dangerously low blood pressure. 98 women participated. Norepinephrine was more effective, causing low blood pressure in only 14.9% of cases compared to 42.6% wit…

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This completed trial tested a new multi-modal monitoring system that combines EEG, brain oxygen levels, blood pressure, and heart rate to better measure anesthesia depth. Researchers enrolled 330 patients undergoing non-cardiac surgery under general anesthesia. The goal was to se…

This study looked at whether adding a small amount of ketamine to standard propofol anesthesia helps keep patients at a consistent depth of sedation during laparoscopic surgery. 106 adults were randomly assigned to receive either ketamine or a placebo (salt water) alongside propo…

This study tested three different drug combinations to sedate patients during upper gastrointestinal endoscopy (a scope procedure to examine the stomach and esophagus). 75 adults were randomly assigned to receive propofol plus either ketamine, dexmedetomidine, or midazolam. Resea…

This study tested whether a nerve block (PECS II) or local anesthesia works better for pain after breast cancer surgery, without using opioids. 124 women undergoing breast surgery were randomly assigned to receive one of the two methods. Researchers measured pain, nausea, and opi…

This study tested whether giving the pain medicine sufentanil as a continuous drip during heart surgery helps patients wake up and leave the ICU sooner compared to giving it as single shots. 65 adults having planned heart surgery took part. The goal was to see if the drip method …

This study tested two different nerve blocks for pain after hallux valgus (bunion) surgery. One group received a standard sciatic block, while the other received a plantar block combined with a distal peroneal block. The goal was to see which approach allows patients to walk bett…

This study tested whether surgeons can give a numbing shot (adductor canal block) during knee replacement surgery as effectively as an anesthesiologist does before surgery. 200 adults with knee osteoarthritis having same-day discharge were randomly assigned to one of the two meth…

This study tested whether a pain plan without strong opioids works as well as one with opioids for children after tonsil surgery. Sixty-two kids aged 3 to 17 were randomly assigned to get either morphine plus other drugs or a combo of dexmedetomidine, acetaminophen, and ketorolac…

This study compared two types of nerve blocks (paravertebral and erector spinae plane block) given before or after video-assisted chest surgery to see which controls pain best. 80 adults participated. The goal was to find the most effective method for reducing acute and long-term…

This study compared two methods of pain relief after hip replacement surgery: a newer technique called erector spinae plane block (ESPB) and the standard epidural. 60 adults having hip replacement took part. Researchers measured pain levels, opioid use, muscle strength, and walki…

This study tested whether an ultrasound-guided belly muscle nerve block (TAP block) can reduce pain and movement during a minimally invasive heart valve replacement (TAVI). Fifty adults having elective TAVI received either the block plus sedation or sedation alone. The goal was t…

This study looked at whether giving a sedative called dexmedetomidine before placing a breathing tube can prevent sudden rises in blood pressure and heart rate in patients with controlled high blood pressure. 70 adults having planned surgery under general anesthesia took part. Th…

This study tested whether using two different nerve blocks together, instead of just one, can reduce the amount of strong painkillers (opioids) needed after lung surgery. 112 adults scheduled for video-assisted thoracoscopic surgery received either a single block or a double bloc…

This study tested whether a device called Optiflow, which delivers warm, humidified oxygen through the nose, could replace the usual face mask during the start of anesthesia. The goal was to see if it could safely oxygenate patients without needing to hold a mask on their face. S…

This study looked at two ways to give pain relief during labor: a standard epidural and a newer technique called dural puncture epidural. The goal was to see which method required fewer extra visits from the doctor to adjust the pain medicine. 130 healthy pregnant women participa…

This study tested whether avoiding morphine during heart surgery could reduce common complications like breathing problems, confusion, and gut issues. 268 adults having planned heart surgery were randomly assigned to receive either standard morphine-based anesthesia or a combinat…

This completed pilot study tested two different IV drug combinations used to sedate people during wisdom tooth removal. One combo used ketamine, the other used propofol instead. Researchers measured how quickly patients recovered, whether they remembered the procedure, and how sa…

This study tested whether transcutaneous electrical acupoint stimulation (TEAS) — a mild electrical pulse on specific acupoints — could reduce postoperative delirium (confusion) in 226 elderly patients having abdominal surgery. Researchers also looked at brain wave (EEG) changes …

This study tested whether adding an extra nerve block (iPACK) to the usual numbing procedure helps people use less strong pain medicine after ACL knee surgery. 90 adults having ACL repair took part. The goal was to see if the extra block improves pain control and recovery.

This study tested whether a special nerve block (erector spinae plane block) could help control pain and reduce the need for strong painkillers after breast reduction surgery. 78 adults took part. The goal was to see if adding this block to standard pain management leads to using…

This study tested whether giving methadone as a pill before heart surgery works as well as giving it through an IV during anesthesia. 41 adults having planned heart surgery took part. Researchers measured how much extra pain medicine they needed and their pain scores after surger…

This study compared three oral sedatives—dexmedetomidine, ketamine, and midazolam—given to 60 children aged 3-7 before inguinal hernia surgery. The goal was to see which drug provides the best sedation and pain control. Results could help doctors choose the safest and most effect…

This study looked at whether teaching patients about pain before a planned hysterectomy (removal of the uterus) could help lower their anxiety, stress, and pain after surgery. 62 adults took part and received either standard care or extra education about pain. The goal was to see…

This study tested a new FDA-approved sedative, remimazolam, against the standard drug propofol for people having a heart ultrasound called TEE. The goal was to see if remimazolam keeps blood pressure and heart rate more stable. 105 adults took part, and researchers measured vital…

This study tested whether using a special laser before applying numbing gel can reduce pain during dental procedures. Twenty adults were split into three groups: laser plus numbing gel, fake laser plus numbing gel, or fake laser plus plain Vaseline. Researchers measured pain leve…

This study looked at two common methods to reduce anxiety in children aged 2-12 before an endoscopy: watching short videos or receiving a nasal spray of dexmedetomidine. Researchers measured anxiety levels at different times before the procedure. The goal was to see which approac…

This study tested two methods of giving a nerve block for shoulder surgery to see if one causes less severe 'rebound pain' when the block wears off. Rebound pain is a short but intense pain that can happen as the anesthesia fades. The researchers compared injecting the anesthetic…

This study tested whether a PENG block (a numbing injection near the hip) can lower inflammation and 30-day death risk in patients over 65 having hip fracture surgery. Researchers measured blood markers of inflammation and pain levels in 60 patients. The goal is to see if this ne…

This study compared two types of nerve blocks—PENG and SFIC—for pain control in 100 adults undergoing hip replacement surgery. The goal was to see which block provides faster and better pain relief. Both techniques are used to reduce the need for opioids and improve recovery.

This study tested a special app called PIRA that teaches children aged 4-10 and their parents about surgery in a fun, interactive way. The goal was to see if using the app before surgery reduces anxiety in both kids and parents, and helps kids wake up more calmly from anesthesia.…

This study tested a new drug called HSK3486 to see if it works as well as propofol for putting adults to sleep before elective surgery. 255 people took part in a randomized, double-blind trial. The main goal was to see how many people had a successful start to anesthesia with HSK…

This study looked at 153 people having liver cancer surgery to see if the type of anesthesia they received affected their recovery and immune response. Researchers compared different anesthesia methods and measured blood markers related to inflammation and immune cell activity. P…

This study looked at 172 patients in the intensive care unit after surgery who needed insulin. It compared two different ways of giving insulin through a vein to see which one kept blood sugar levels more stable. The goal was to find out if using a separate line just for insulin …

This study looked at 107 women having a first-time cervical procedure (LEEP) for abnormal cells. Researchers compared how local anesthesia (cervical block) versus general or spinal anesthesia affected the size of the removed tissue. The goal was to see if the anesthesia method in…

This study looked at whether a personalized breathing method during chest surgery could lower the chance of lung problems afterward in children under 5. Sixty-three kids having chest surgery were split into two groups: one got the standard breathing settings, the other got settin…

This study looked at how the body processes lidocaine, a common painkiller, in young (under 40) and elderly (over 70) patients during surgery. The goal was to find the best dose for older adults to manage pain safely while avoiding side effects. 67 participants were monitored to …

This study looked at how different amounts of mannitol, a medicine used to reduce brain swelling, change blood osmolarity (a measure of blood thickness) in people with traumatic brain injury. Researchers observed 64 patients aged 18-40 with mild to moderate head injuries. The goa…

This study used a special belt (electrical impedance tomography) to monitor lung function in 30 children aged 1 to 6 years during anesthesia for MRI scans. The goal was to see how much lung collapse occurs and how quickly it resolves after the procedure. The findings could help m…

This study looked at whether checking patients by phone before surgery leads to more cancellations than checking them in person. Researchers reviewed records of 1176 adults scheduled for non-cardiac surgery at two hospitals. The goal was to see if phone assessments are a safe and…

This study looked at 332 stroke patients to see if general anesthesia or conscious sedation is better during a procedure to remove blood clots from the brain. The goal was to find which method leads to better recovery and fewer complications within the first week. The results cou…

This study looked at how a low dose of the sedative drug dexmedetomidine affects pain signals in the brain. Researchers used brain scans to measure changes in fluid flow. 17 healthy adults took part. The goal was to understand the drug's pain-relieving effects, not to test a new …

This study tested whether an alert in the electronic medical record can encourage anesthesia providers to reduce excessive fresh gas flow during surgery. Over 300 providers participated at Stanford University. The goal was to see if the alert leads to lower gas use over time.

This study looked at how a low dose of the anesthetic sevoflurane affects memory and brain responses to pain. Forty-two healthy adults inhaled sevoflurane or no drug while receiving mild electric shocks and performing memory tasks. Brain scans (fMRI) measured activity changes. Th…

This study observed over 6,400 adults undergoing elective surgery to see how doctors prescribe sugammadex, a drug that reverses muscle paralysis from anesthesia. Researchers collected data from routine care, without extra tests or treatments. The goal was to understand prescripti…

This study tested whether giving 50% or 100% oxygen before removing a breathing tube after anesthesia leads to fewer drops in oxygen levels. 119 patients were monitored after surgery. The goal is to find the safest oxygen setting to prevent breathing problems during recovery.

This study looked at whether using remifentanil, a fast-acting opioid, during general anesthesia for emergency C-sections affects how well premature babies adapt after birth. Researchers compared two groups of mothers and their premature babies: one group received remifentanil, t…

This completed study looked at 204 patients who had a kidney removed (nephrectomy) to find out what factors might lead to chronic pain lasting months or years after surgery. Researchers measured pain levels at 1 hour, 3 months, and 1 year after the operation using a simple 0-to-1…

This study looked at whether video consultations (teleconsultations) could work well for children needing anesthesia checkups during the COVID-19 pandemic. Researchers tracked how often these video visits failed and had to switch to a phone call or in-person visit. The goal was t…

This study looked at 200 adults having day surgery with general anesthesia. One group received their pain medication prescription before surgery, the other after. Researchers tracked how many people had moderate-to-severe pain at home within 24 hours. The goal was to see if givin…

This study looked at whether giving spinal anesthesia quickly (15 seconds) or slowly (90 seconds) changes blood pressure and heart function in elderly patients with hip fractures. Eighty-four patients were randomly assigned to one of the two speeds. The researchers measured blood…

This study compared two methods—CoolStick and ethyl chloride spray—for checking how well anesthesia numbs the skin before a planned C-section. 64 pregnant patients were included. The goal was to see which tool works better for measuring numbness to light touch and cold. This was …

This study tested a new method to remove carbon dioxide from anesthesia breathing circuits without using chemical filters. Current chemical filters can produce harmful compounds, increase costs, and create environmental waste. The study involved 286 low-to-medium risk surgery pat…

This study looked at 485 patients who had coronary artery bypass surgery to see if a computer method called fuzzy logic could better predict who is at risk of dying. Fuzzy logic is a way to handle uncertain information, similar to how doctors think. The goal is to create a tool t…

This study tested a new method (MTPI) for giving anesthesia drugs to make inserting a breathing tube faster and easier. It involved 154 adults with higher airway risk (e.g., obesity). The goal was to see if MTPI works better than the standard approach.

This study used artificial intelligence to learn the patterns of reduced blood flow to the brain during planned surgeries. 60 patients having carotid artery surgery or stroke clot removal were monitored with non-invasive devices. The goal was to teach AI to recognize these patter…

This study compared two methods for placing a special breathing tube (double-lumen tube) used in lung surgery. 916 adults having thoracic surgery were randomly assigned to get the tube placed using either a video laryngoscope (with a camera) or a traditional direct laryngoscope. …

This study tested a new portable device called MARIE that measures carbon dioxide (CO2) in the breath of 40 adults after surgery. The goal was to see if MARIE works as well as standard hospital monitors for detecting breathing problems early. Researchers compared MARIE's readings…

This study looked at how two different hand muscles recover from muscle relaxants given during surgery. In 57 patients, researchers used EMG monitors to compare recovery in the thumb muscle versus the pinky muscle. The goal was to see if one muscle gives a better signal for when …

This study tested three different breathing devices (GMA-Tulip, i-gel, and LMA-Supreme) in 498 adults having surgery under general anesthesia. The goal was to see which device provided the best airway support and safety. Doctors used a small camera to check how well each device w…

This study tested two types of glottis mask airways (a tube placed in the throat to help patients breathe during anesthesia) to see which one reduces the risk of stomach acid backing up into the throat. The tulip-shaped tip is designed to fit the larynx better than the classical …

This study tested two non-invasive monitors that track pain in children aged 1-12 during surgery. The monitors measure skin conductance and a pain index to see how well they detect pain events. Researchers compared their readings to find which one is more reliable for guiding pai…

This study looked at 120 children with glaucoma or suspected glaucoma who needed eye exams under anesthesia. The goal was to see if a standard anesthesia plan could produce consistent and reliable eye pressure measurements. Researchers measured how deep the anesthesia was and com…

This study looked at 320 adults who had heart surgery to see how well two different risk scores (EuroSCORE-II and POSPOM) predict the chance of dying in the hospital. Researchers calculated each patient's scores before surgery and compared them to what actually happened. The goal…

This study tested whether a non-invasive monitor called the Nociception Level (NoL) index can measure pain in children under general anesthesia. Researchers gave 30 children aged 5 to 12 brief, mild electrical stimulations of different strengths before surgery and recorded how th…

This study looked at whether a video call (telemedicine) is as good as an in-person visit for checking a patient's health before surgery. 172 adults scheduled for surgery at a French hospital took part. Researchers compared how well each method captured important details like med…

This study tested how well BD NRFit spinal needles and syringes work in real-world medical settings. A total of 161 patients receiving anesthesia or pain relief procedures were included. Researchers measured successful needle placement, syringe function, and safety issues like he…

This study looked at over 3,600 adults having major surgery to find out which of two blood pressure drugs (norepinephrine or phenylephrine) works best to prevent complications like kidney injury or death. Patients received one of the two drugs during their operation. The goal was…

This study used a special brain imaging technique called near-infrared spectroscopy to see how the brain responds to pain and sounds while people are under general anesthesia. 44 healthy volunteers aged 12-30 were given either a painkiller (remifentanil) or a placebo. The goal wa…

This study tested whether a 4-channel EEG brain monitor can help doctors give the right amount of sedation during ERCP, a procedure to treat bile duct problems. 84 adults received propofol sedation, and the monitor tracked their brain activity to guide dosing. The goal was to kee…

This study looked at 348 people who had open heart surgery with a heart-lung machine. Researchers wanted to see if the ratio of time on the machine to time the heart was stopped affected complications or death. The goal is to find a better way to predict and improve recovery afte…

This study tested whether a short power-nap (less than 30 minutes) can help anesthesiology residents perform better after working night shifts. 44 residents took part in high-fidelity simulations to measure their technical and non-technical skills. The goal was to see if napping …

This study looked at how the brain processes what we see while under anesthesia. Researchers used brain scans (fMRI) to measure brain activity in 36 healthy adults during sedation with propofol. They also tested if using ultrasound on the brain could help people wake up faster. T…

This study looked at whether a short mental training session could help anesthesia residents feel less stressed before performing an epidural on a pregnant patient. Thirty-two residents were split into two groups: one got mental preparation, the other did not. Researchers measure…

This study looked at whether patients getting ready for surgery can effectively preoxygenate themselves by holding the oxygen mask. 110 adults scheduled for surgery under general anesthesia took part. The main goal was to see how many could reach a high oxygen level within 3 minu…

This completed study looked at how two different anesthesia gas flows affect eye pressure and optic nerve during kidney stone surgery. Sixty adults having the procedure were randomly assigned to receive either minimal low-flow or high-flow anesthesia. Researchers measured eye pre…

This study tested whether giving a small amount of fluid (3 ml per kg over 2 minutes) can predict if a child needs more fluids during surgery. Researchers measured heart function after the small test and compared it to the standard larger fluid dose. The goal is to help anesthesi…

This study tested a new method to set breathing machines for 60 children under anesthesia. Instead of using standard formulas, doctors adjusted the machine based on real-time carbon dioxide measurements. The goal was to find the right air volume to keep children breathing safely.…