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Tailoring blood flow during surgery may cut deadly complications

NCT ID NCT05648279

Completed Disease control Sponsor: Universitätsklinikum Hamburg-Eppendorf Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This large international trial tested whether keeping a patient's blood flow (cardiac index) at their own personal baseline during major abdominal surgery reduces serious complications. Over 1,100 high-risk adults aged 45 and older took part. The goal was to see if this personalized approach lowers the chance of kidney injury, heart injury, severe infections, or death within a week after surgery compared to standard care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
personalized hemodynamic management (tailoring blood flow during surgery to each patient's own baseline)
What this could lead to
If successful, this approach could become a new standard to reduce serious complications like kidney injury, heart injury, and infections after major abdominal surgery.
What could go wrong
This is a completed trial, but results are not yet published. The benefit may be small or not apply to all high-risk patients. The intervention requires extra monitoring equipment and planning.

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Conditions

The condition(s) this trial relates to.

Postoperative Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANESTHESIA CARDIAC OUTPUT POSTOPERATIVE COMPLICATIONS SURGERY

Contacts and locations

Locations

  • Clínica Universidad de Navarra

    Pamplona, Spain

  • Hvidovre Hospital

    Copenhagen, Denmark

  • LMU Munich

    Munich, Germany

  • Medical University of Graz

    Graz, Austria

  • Rigshospitalet

    Copenhagen, Denmark

  • University Hospital Düsseldorf

    Düsseldorf, Germany

  • University Hospital Marburg

    Marburg, Germany

  • University Hospital Plzen

    Pilsen, Czechia

  • University Hospital RWTH Aachen

    Aachen, Germany

  • University Medical Center Copenhagen Bispebjerg and Frederiksberg

    Copenhagen, Denmark

  • University Medical Center Hamburg

    Hamburg, Germany

  • University Medical Center Schleswig Holstein, Lübeck

    Lübeck, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.