Low-Dose anesthesia may change how pain impacts memory
NCT ID NCT06044740
First seen Nov 01, 2025 · Last updated Jun 20, 2026 · Updated 41 times
Summary
This study looked at how a low dose of the anesthetic sevoflurane affects memory and brain responses to pain. Forty-two healthy adults inhaled sevoflurane or no drug while receiving mild electric shocks and performing memory tasks. Brain scans (fMRI) measured activity changes. The goal was to understand how anesthesia and pain together influence memory formation.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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University of Pittsburgh
Pittsburgh, Pennsylvania, 15213, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Sevoflurane (an inhaled anesthetic gas)
What this could lead to
If successful, this could help researchers understand how anesthesia and pain interact to affect memory, potentially improving pain management during procedures.
What could go wrong
This is a very early, small study in healthy volunteers, not patients. It uses low drug doses and artificial pain, so findings may not apply to real-world surgery or chronic pain.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.