Heart surgery without morphine: safer or not?
NCT ID NCT04940689
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether avoiding morphine during heart surgery could reduce common complications like breathing problems, confusion, and gut issues. 268 adults having planned heart surgery were randomly assigned to receive either standard morphine-based anesthesia or a combination of dexmedetomidine and lidocaine. The researchers tracked major complications in the first 48 hours after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dexmedetomidine and lidocaine (instead of morphine)
What this could lead to
If it works, this could lead to safer anesthesia for heart surgery patients, with fewer side effects like breathing trouble or confusion.
What could go wrong
This is a single completed study with 268 people. Results may not apply to all heart surgeries, and the new drugs have their own risks like low blood pressure or slow heart rate.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Amiens Univesrity Hospital
Amiens, France
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CAEN university Hospital
Caen, France
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Lille Hopistal University
Lille, France
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Montpellier University Hospital
Montpellier, France
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Rouen University Hospital
Rouen, France, Normandy, 76031, France