New sleep drug for surgery could rival propofol

NCT ID NCT04711837

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new drug called HSK3486 to see if it works as well as propofol for putting adults to sleep before elective surgery. 255 people took part in a randomized, double-blind trial. The main goal was to see how many people had a successful start to anesthesia with HSK3486 compared to propofol.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

HSK3486 injectable emulsion

What this could lead to

If successful, HSK3486 could offer a new option for putting people to sleep before surgery, possibly with less injection pain than current drugs.

What could go wrong

This is a late-stage trial, but the drug may not prove safer or more effective than propofol. Results may not apply to all surgeries or patient types.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Arizona Research Center

    Phoenix, Arizona, 85053, United States

  • Duke University

    Durham, North Carolina, 27705, United States

  • Endeavor Clinical Trials, LLC

    San Antonio, Texas, 78229, United States

  • HD Research

    Bellaire, Texas, 77401, United States

  • JBR Clinical Research

    Salt Lake City, Utah, 84107, United States

  • Lotus Clinical Research, LLC

    Pasadena, California, 91105, United States

  • New York City Heath and Hospitals

    New York, New York, 10013, United States

  • Phoenix Clinical Research, LLC

    Tamarac, Florida, 33321, United States

  • Plano Surgical Hospital

    Plano, Texas, 75093, United States

  • Stony Brook University Hospital

    Stony Brook, New York, 11794, United States

  • The Ohio State University Research Foundation

    Columbus, Ohio, 43210, United States

  • The University of Chicago Medicine

    Chicago, Illinois, 60637, United States

  • UNC Health Care System

    Chapel Hill, North Carolina, 27599, United States