New sleep drug for surgery could rival propofol

NCT ID NCT04711837

Completed Symptom relief Sponsor: Haisco-USA Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new drug called HSK3486 to see if it works as well as propofol for putting adults to sleep before elective surgery. 255 people took part in a randomized, double-blind trial. The main goal was to see how many people had a successful start to anesthesia with HSK3486 compared to propofol.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HSK3486 injectable emulsion
What this could lead to: If successful, HSK3486 could offer a new option for putting people to sleep before surgery, possibly with less injection pain than current drugs.
What could go wrong: This is a late-stage trial, but the drug may not prove safer or more effective than propofol. Results may not apply to all surgeries or patient types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANESTHESIA

Contacts and locations

Locations

Arizona Research Center

Phoenix, Arizona, 85053, United States
Duke University

Durham, North Carolina, 27705, United States
Endeavor Clinical Trials, LLC

San Antonio, Texas, 78229, United States
HD Research

Bellaire, Texas, 77401, United States
JBR Clinical Research

Salt Lake City, Utah, 84107, United States
Lotus Clinical Research, LLC

Pasadena, California, 91105, United States
New York City Heath and Hospitals

New York, New York, 10013, United States
Phoenix Clinical Research, LLC

Tamarac, Florida, 33321, United States
Plano Surgical Hospital

Plano, Texas, 75093, United States
Stony Brook University Hospital

Stony Brook, New York, 11794, United States
The Ohio State University Research Foundation

Columbus, Ohio, 43210, United States
The University of Chicago Medicine

Chicago, Illinois, 60637, United States
UNC Health Care System

Chapel Hill, North Carolina, 27599, United States

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