C-Section drug showdown: norepinephrine beats phenylephrine for stable blood pressure

NCT ID NCT07327320

Completed Disease control Sponsor: Tam Anh Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compared two medications, norepinephrine and phenylephrine, given continuously during C-sections to prevent dangerously low blood pressure. 98 women participated. Norepinephrine was more effective, causing low blood pressure in only 14.9% of cases compared to 42.6% with phenylephrine, and also led to steadier heart rates. Both drugs were safe for the babies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: norepinephrine and phenylephrine
What this could lead to: If confirmed, this could lead to a preferred drug for preventing low blood pressure during C-sections, improving safety and comfort for mothers.
What could go wrong: This is a single, small Phase 4 trial. Results may not apply to all hospitals or patients, and long-term effects were not studied.

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Conditions

The condition(s) this trial relates to.

hypotensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANESTHESIA CESAREAN SECTION CONTROLLED HYPOTENSION FOR NASAL SURGERIES HYPOTENSION, CONTROLLED SPINAL

Contacts and locations

Locations

Tam Anh TP. Ho Chi Minh General Hospital

Ho Chi Minh City, Ho Chi Minh, 700000, Vietnam

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