Stomach drug may speed up digestion for semaglutide users before surgery

NCT ID NCT07254715

Recruiting now Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 4 trial tests whether itopride, a drug that helps move food through the stomach, can reduce the risk of aspiration during anesthesia in people taking semaglutide. Sixty diabetic patients scheduled for hysterectomy will receive itopride or a placebo for 7 days before surgery. The main goal is to see if itopride lowers leftover stomach contents after fasting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Itopride (a drug that helps move food through the stomach)
What this could lead to: If it works, this could offer a simple way to reduce stomach contents before surgery for people on semaglutide, lowering aspiration risk.
What could go wrong: This is a small, early-phase trial with only 60 participants. Results may not apply to all patients, and itopride may not significantly improve gastric emptying.

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Conditions

The condition(s) this trial relates to.

gastroparesis type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANESTHESIA SEMAGLUTIDE-INDUCED GASTRIC MOTILITY

Contacts and locations

Locations

faculty of medicine, Ain Shams University
RECRUITING

Cairo, Cairo Governorate, 11591, Egypt

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