Gastroparesis

This trial investigates whether adding a Braun anastomosis—a connection between two loops of the small intestine—during pancreatic cancer surgery can lower the risk of delayed gastric emptying, a frequent complication where the stomach takes too long to empty. About 264 adults sc…

This study tests whether inflating a small balloon in the pylorus (the valve between stomach and small intestine) during minimally invasive esophageal cancer surgery can prevent delayed stomach emptying, a common complication. About 116 patients will be randomly assigned to recei…

This study tests whether a Botox injection into the stomach valve works as well as a surgical cut to prevent food from emptying too slowly after esophagus removal. About 170 adults having elective esophagectomy will be randomly assigned to one of the two procedures. Researchers w…

This study tests whether the Medtronic 780G automated insulin pump can improve blood sugar control in adults with type 1 diabetes who also have gastroparesis (stomach paralysis). Participants will use the device for three months, and researchers will measure how often blood sugar…

This study will follow 600 adults who are already scheduled to receive a standard procedure called POEM, which uses a scope to cut tight muscles in the throat or stomach. The goal is to see how well the procedure works over time for conditions like achalasia, gastroparesis, and Z…

This study tests whether transferring gut bacteria from healthy donors (called washed microbiota transplantation) can help people with diabetic gastroparesis—a condition where the stomach empties too slowly, causing bloating, nausea, and fullness. Researchers will give 46 adults …

This study tests whether traditional Chinese acupuncture can help people whose stomachs stop working properly after partial stomach removal surgery. 176 adults will receive either real or sham acupuncture alongside standard care. The goal is to see if acupuncture shortens the tim…

This early study tests whether a weekly shot of low-dose growth hormone can improve symptoms like nausea, fullness, and belly pain in people with gastroparesis (stomach paralysis) that hasn't responded to standard treatments. Ten adults will receive the drug for 12 weeks, and res…

This study tests whether domperidone, a drug that helps the stomach empty food, can reduce symptoms like pain, bloating, nausea, and vomiting in people with chronic digestive disorders. About 200 patients who have not improved with standard treatments will take domperidone and re…

This program gives domperidone to teenagers aged 12 to 21 who have severe stomach or reflux problems that haven't gotten better with standard treatments. The goal is to see if the drug can reduce their symptoms. Up to 20 participants will be enrolled.

This study looks at whether chewing gum after gastrointestinal surgery can help the bowels start working again sooner. About 96 adults having open abdominal surgery will either chew gum or not, and researchers will measure how quickly they pass gas and have their first bowel move…

This study is tracking how well a procedure called G-POEM helps people with gastroparesis, a condition where the stomach empties too slowly. Researchers will follow 75 adults who are already scheduled for the procedure to see if their symptoms like nausea, bloating, and feeling f…

This study looks at whether sipping water or a carbohydrate-rich drink while waiting for a planned C-section is safer and leads to a better recovery. About 190 women will be randomly assigned to one of the two drinks. Researchers will use ultrasound to check stomach contents and …

This study looks at whether problems with how the stomach and esophagus move increase the risk of aspiration (food or liquid going into the lungs) in children with brain-related disabilities. It compares two drugs, prucalopride and famotidine, to see which better reduces symptoms…

This phase 4 trial tests whether itopride, a drug that helps move food through the stomach, can reduce the risk of aspiration during anesthesia in people taking semaglutide. Sixty diabetic patients scheduled for hysterectomy will receive itopride or a placebo for 7 days before su…

This study looks at whether ear acupuncture can help with slow stomach emptying after abdominal surgeries like Whipple or gastrectomy. Researchers will track symptoms like nausea and fullness in 159 adults aged 40-70. The goal is to see if this simple, needle-based therapy improv…

This study watches 186 adults who take GLP-1 drugs (like Ozempic) and are having planned surgery. Researchers use a stomach ultrasound to check how much food or liquid is left in the stomach after stopping the drug for different lengths of time. The goal is to see if longer pause…

This study collects small tissue samples from the stomach and upper intestine of people with severe gastroparesis (delayed stomach emptying). Researchers look for specific cell abnormalities that might predict whether a patient will benefit from a gastric electrical stimulation d…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study is creating a registry of up to 5,000 patients with various gut movement disorders, such as GERD, gastroparesis, and IBS. Doctors will use standard criteria to make accurate diagnoses and collect patient-reported outcomes. The goal is to improve understanding of these …

This study tests a non-invasive device called Gastric Alimetry that records stomach electrical activity in people with functional dyspepsia or gastroparesis. Researchers will compare recordings taken before and during medication to see if the device can predict which treatment wo…

This study looks at people with gastroparesis (slow stomach emptying) who have a gastric electrical stimulator (GES) implanted. Researchers will turn off the device for up to four hours to see how it changes insulin and other hormone levels. The goal is to understand the device's…

This study looks at whether a nutritional drink with proteins and carbohydrates slows down how fast the stomach empties in people aged 60 to 90. Twenty-five volunteers will drink either the test formula or a plain carbohydrate drink on two separate days, and doctors will track st…

This study looks at how different amounts of clear liquids (like water or juice) affect stomach contents in teens aged 13-17 before an upper GI endoscopy. Participants are randomly assigned to drink 3, 5, 7, or 10 ml of clear fluid per kilogram of body weight two hours before the…

This study uses ultrasound imaging to measure how quickly the stomach empties after feeding in healthy newborns and infants. Researchers will watch the stomach shrink back to its starting size after babies drink clear liquids, breast milk, or formula. The goal is to learn normal …

This study is building a large database of 3000 people with gastroparesis, a condition that causes nausea, vomiting, and stomach pain. Researchers will follow patients over time to see how different treatments—like nerve stimulation, immunotherapy, or pyloric therapies—affect the…

This study is looking at whether long-term blood sugar levels (HbA1c) affect how fast the stomach empties before surgery. Slow stomach emptying can increase the risk of stomach contents entering the lungs during anesthesia. Researchers will use ultrasound to measure stomach conte…

This study looks at whether ultrasound can reliably measure how much is in a child's stomach before surgery, which could help prevent rare but serious complications like breathing in stomach contents. About 60 children aged 2 to 18 will have stomach ultrasounds, and some will als…

This study is creating a registry of 250 people with symptoms of gastroparesis or functional dyspepsia, such as nausea, vomiting, and abdominal pain. Participants will fill out questionnaires, take a nutrient drink test, and have a gastric emptying scan. The goal is to collect da…

This study aims to find out if people with gastroparesis (stomach paralysis) have abnormalities in the pyloric sphincter, the valve between the stomach and small intestine. Researchers will use special imaging tools to measure how flexible and open this valve is. The study will e…

This study is creating a national registry of 216 children, teens, and young adults (ages 8-25) with gastroparesis or similar symptoms. Researchers will track how symptoms like nausea and stomach pain change over 48 weeks using questionnaires and stomach-emptying tests. The goal …

This study looks at whether eosinophilic gastritis, a rare stomach condition, causes problems with how the stomach moves food. Researchers will use a special scan after an oatmeal meal to check stomach emptying in 30 people. The goal is to better understand if these motility issu…

This study aims to develop a simple tool to predict whether a person's stomach will still have food or liquid in it before a sedated endoscopy. Having a full stomach during sedation raises the risk of serious complications like choking. Researchers will study 5,000 adults to iden…

This study looks at whether people taking GLP-1 or GIP medications (like Ozempic or Mounjaro) have more food left in their stomach after standard fasting before surgery. Researchers will use ultrasound to measure stomach volume in 150 adults who either fasted for 8 hours or had a…

This study looks at why people with diabetes develop gastroparesis, a condition where the stomach doesn't empty properly. Researchers will collect blood and stomach tissue samples from 50 participants to examine how certain molecules affect stomach muscle function. The goal is to…

This study tests whether a non-invasive device called Body Surface Gastric Mapping can predict which patients with gastroparesis will benefit from G-POEM surgery. Researchers will monitor 20 patients before and after the procedure using a sticky electrode patch on the stomach are…

This observational study aims to understand stomach electrical activity in children aged 8-25 with digestive issues like slow stomach emptying or chronic pain. Researchers will use a non-invasive device (BSGM) to record stomach signals for up to 4 hours and compare them to health…

This study looks at why some people develop delayed gastric emptying (stomach not emptying properly) after pancreatic surgery. Researchers will review medical records of 3500 patients who had pancreatic surgery to find risk factors, such as surgical method or feeding tube use. Th…

This study looks at how quickly the stomach empties in women during early labor when they drink either water or a sports drink. It includes women with and without epidural pain relief. The goal is to understand digestion during labor, not to test a treatment.