Functional gastric disease

This trial investigates whether adding a Braun anastomosis—a connection between two loops of the small intestine—during pancreatic cancer surgery can lower the risk of delayed gastric emptying, a frequent complication where the stomach takes too long to empty. About 264 adults sc…

This expanded access program offers avexitide to people with post-bariatric hypoglycemia (dangerously low blood sugar) after Roux-en-Y gastric bypass. Eligible patients include those who completed the LUCIDITY trial or other avexitide studies. Participants receive a daily injecti…

This study tests whether a newer acid-reducing drug (vonoprazan) works better than a standard one (esomeprazole) for clearing H. pylori, a bacteria that can cause stomach ulcers and indigestion. About 80 adults with H. pylori will take one of the two drug combinations for 14 days…

This study tests whether inflating a small balloon in the pylorus (the valve between stomach and small intestine) during minimally invasive esophageal cancer surgery can prevent delayed stomach emptying, a common complication. About 116 patients will be randomly assigned to recei…

This study tests whether a continuous glucose monitor (CGM) can better detect low blood sugar episodes in people who had gastric bypass surgery and now have late dumping syndrome. Sixty participants will either use the iCan i3 CGM or standard fingerstick tests for 60 days. The go…

This study tests whether a Botox injection into the stomach valve works as well as a surgical cut to prevent food from emptying too slowly after esophagus removal. About 170 adults having elective esophagectomy will be randomly assigned to one of the two procedures. Researchers w…

This study tests whether the Medtronic 780G automated insulin pump can improve blood sugar control in adults with type 1 diabetes who also have gastroparesis (stomach paralysis). Participants will use the device for three months, and researchers will measure how often blood sugar…

This study tests a new way to treat children with gut-brain disorders like cyclic vomiting and functional dyspepsia. The therapy uses a mild electrical nerve stimulation to the ear, personalized based on each child's nerve activity. The goal is to improve quality of life and redu…

This study will follow 600 adults who are already scheduled to receive a standard procedure called POEM, which uses a scope to cut tight muscles in the throat or stomach. The goal is to see how well the procedure works over time for conditions like achalasia, gastroparesis, and Z…

This study tests whether adding a probiotic called Saccharomyces boulardii to a standard antibiotic cocktail helps clear Helicobacter pylori infections that didn't respond to earlier treatments. About 1,248 adults who have failed prior H. pylori therapy will be randomly assigned …

This study tests if a tube-like device called a stent, placed through a scope, can reverse gastric bypass surgery in 20 people who have serious complications like low blood sugar, blockages, or liver problems. The goal is to see if the stent works as well as surgery to fix these …

This study tests whether transferring gut bacteria from healthy donors (called washed microbiota transplantation) can help people with diabetic gastroparesis—a condition where the stomach empties too slowly, causing bloating, nausea, and fullness. Researchers will give 46 adults …

This study looks at whether a small, wearable continuous glucose monitor (CGM) can accurately diagnose dumping syndrome in people who have had surgery for esophageal cancer. Dumping syndrome happens when food moves too quickly into the small intestine, causing symptoms like dizzi…

This study compares intravenous famotidine (a stomach acid reducer) and oral antacids (like Maalox) for treating dyspepsia (stomach pain) in the emergency department. About 80 adults with upper abdominal pain will rate their pain every 15 minutes for an hour. The goal is to see w…

This study looks at how different FODMAP diets affect gut bacteria, gut barrier function, and symptoms in people with functional gastrointestinal disorders like IBS. About 60 adults will follow either a low FODMAP, gentle FODMAP, or standard dietary advice for two weeks. Research…

This study tests whether two medications, amitriptyline and trifluoperazine, can reduce stomach symptoms in people with functional dyspepsia—a condition where the stomach feels upset without a clear cause. About 120 adults will take one of the drugs or stick with standard treatme…

This study looks at why people with indigestion and diabetes have stomach issues, possibly due to increased sensitivity in the small intestine. Researchers are testing ondansetron, a drug used for nausea, to see if it can reduce symptoms like fullness, discomfort, and nausea. The…

This study tests whether a natural extract from the hyacinth bean (EDL) can reduce stomach symptoms like pain, fullness, and burning in people with functional dyspepsia. About 100 adults will take EDL or a placebo daily for 12 weeks. Researchers will measure symptom changes using…

This study tests whether traditional Chinese acupuncture can help people whose stomachs stop working properly after partial stomach removal surgery. 176 adults will receive either real or sham acupuncture alongside standard care. The goal is to see if acupuncture shortens the tim…

This early study tests whether a weekly shot of low-dose growth hormone can improve symptoms like nausea, fullness, and belly pain in people with gastroparesis (stomach paralysis) that hasn't responded to standard treatments. Ten adults will receive the drug for 12 weeks, and res…

This study tests whether domperidone, a drug that helps the stomach empty food, can reduce symptoms like pain, bloating, nausea, and vomiting in people with chronic digestive disorders. About 200 patients who have not improved with standard treatments will take domperidone and re…

This program gives domperidone to teenagers aged 12 to 21 who have severe stomach or reflux problems that haven't gotten better with standard treatments. The goal is to see if the drug can reduce their symptoms. Up to 20 participants will be enrolled.

This study is testing whether a daily capsule of holy basil extract can reduce stomach inflammation and improve symptoms like pain, bloating, and nausea in adults with indigestion. Twenty-seven participants will take the supplement for 28 days and undergo endoscopies and blood te…

This study tests whether wearing virtual reality goggles during a colonoscopy or upper endoscopy can help patients need less sedation. Ten adults aged 21 to 65 will receive minimal sedation and wear a VR headset during the procedure. Researchers will measure how much sedative is …

This study tests if a digital hypnotherapy program can reduce stomach and gut symptoms like pain, bloating, and nausea. Researchers will enroll 100 adults with upper GI disorders (e.g., functional dyspepsia) and measure changes using symptom questionnaires. The approach is non-in…

This study tests whether pressing small seeds on specific ear points can help people with functional dyspepsia (chronic stomach discomfort) who also have insomnia. Researchers will track symptom relief and sleep quality in 176 adults over 8 weeks, and explore how the treatment af…

This study looks at whether chewing gum after gastrointestinal surgery can help the bowels start working again sooner. About 96 adults having open abdominal surgery will either chew gum or not, and researchers will measure how quickly they pass gas and have their first bowel move…

This study is tracking how well a procedure called G-POEM helps people with gastroparesis, a condition where the stomach empties too slowly. Researchers will follow 75 adults who are already scheduled for the procedure to see if their symptoms like nausea, bloating, and feeling f…

This study looks at whether sipping water or a carbohydrate-rich drink while waiting for a planned C-section is safer and leads to a better recovery. About 190 women will be randomly assigned to one of the two drinks. Researchers will use ultrasound to check stomach contents and …

This Phase 3 trial tests whether Lianxiaxiaopi Granules, a traditional Chinese herbal medicine, can relieve symptoms of postprandial distress syndrome (stomach discomfort, fullness, or early fullness after meals). 342 adults aged 18-65 will take the granules or a placebo three ti…

This study tests whether using virtual reality can help relieve stomach pain and other symptoms in people with functional dyspepsia, a condition where the stomach feels upset without a clear cause. Researchers at Mayo Clinic will enroll 30 adults who meet specific criteria. Parti…

This study tests whether ketotifen, a drug that stabilizes certain immune cells, can reduce stomach pain in children aged 8-17 with functional dyspepsia and high levels of eosinophils in the gut. Participants will receive both ketotifen and a placebo at different times to compare…

This study tests two digital treatments for children aged 8-17 with chronic stomach pain caused by gut-brain interaction disorders. After a 4-week online education program, participants are randomly assigned to either internet-based cognitive behavioral therapy (iCBT) or gut-dire…

This study tests a daily supplement containing two types of probiotics and ginger extract in 198 adults with functional dyspepsia, a condition causing stomach pain, fullness, and burning. Participants take one capsule daily for 8 weeks. Researchers will measure changes in symptom…

This study tests whether a probiotic called Clostridium butyricum can help reduce anxiety and depression in people with functional dyspepsia (a common stomach disorder). 180 adults will receive either the probiotic or a placebo for 4 weeks, alongside standard stomach medication. …

This study tests whether a probiotic called Bacillus coagulans can reduce anxiety and depression in people with functional dyspepsia, a common stomach disorder. 180 adults will receive either the probiotic or a placebo for 4 weeks, alongside standard treatment. The main goal is t…

This study looks at whether problems with how the stomach and esophagus move increase the risk of aspiration (food or liquid going into the lungs) in children with brain-related disabilities. It compares two drugs, prucalopride and famotidine, to see which better reduces symptoms…

This phase 4 trial tests whether itopride, a drug that helps move food through the stomach, can reduce the risk of aspiration during anesthesia in people taking semaglutide. Sixty diabetic patients scheduled for hysterectomy will receive itopride or a placebo for 7 days before su…

This study tests whether combining a nerve-stimulating device (placed on the ear) with behavioral therapy can reduce stomach pain and anxiety in people with functional dyspepsia, a condition where the stomach feels upset without a clear cause. Researchers will track symptoms and …

This study tests whether a simple biofeedback technique—teaching people to control their abdominal and chest muscles using a video—can reduce visible bloating after meals. 100 adults with irritable bowel syndrome, dyspepsia, or functional bloating will be randomly assigned to eit…

This study tests whether press needles (small needles taped to the skin) on body and ear acupuncture points, combined with medication, can reduce symptoms and improve quality of life in people with functional dyspepsia (stomach pain or discomfort without a clear cause). About 38 …

This study tests a type of talking therapy called exposure-based cognitive behavioral therapy (CBT) for adults who have both functional dyspepsia (a stomach condition causing pain and fullness) and avoidant/restrictive food intake disorder (ARFID), leading to weight loss. Fifty p…

This study looks at whether ear acupuncture can help with slow stomach emptying after abdominal surgeries like Whipple or gastrectomy. Researchers will track symptoms like nausea and fullness in 159 adults aged 40-70. The goal is to see if this simple, needle-based therapy improv…

This study tests a drink made from Chios mastic, a natural resin, to see if it can reduce indigestion symptoms. Sixty adults with dyspepsia will drink either the mastic beverage or a placebo daily for three months. Researchers will measure changes in symptom severity and quality …

This study watches 186 adults who take GLP-1 drugs (like Ozempic) and are having planned surgery. Researchers use a stomach ultrasound to check how much food or liquid is left in the stomach after stopping the drug for different lengths of time. The goal is to see if longer pause…

This study collects small tissue samples from the stomach and upper intestine of people with severe gastroparesis (delayed stomach emptying). Researchers look for specific cell abnormalities that might predict whether a patient will benefit from a gastric electrical stimulation d…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study is creating a registry of up to 5,000 patients with various gut movement disorders, such as GERD, gastroparesis, and IBS. Doctors will use standard criteria to make accurate diagnoses and collect patient-reported outcomes. The goal is to improve understanding of these …

This study tests a non-invasive device called Gastric Alimetry that records stomach electrical activity in people with functional dyspepsia or gastroparesis. Researchers will compare recordings taken before and during medication to see if the device can predict which treatment wo…

This study looks at people with gastroparesis (slow stomach emptying) who have a gastric electrical stimulator (GES) implanted. Researchers will turn off the device for up to four hours to see how it changes insulin and other hormone levels. The goal is to understand the device's…

This study aims to find out how many relatives of people with celiac disease have non-celiac wheat sensitivity (NCWS) or other gut issues like IBS. Participants will follow a strict wheat-free diet for 6 weeks and report their symptoms. The goal is to better understand the link b…

This study looks at whether a nutritional drink with proteins and carbohydrates slows down how fast the stomach empties in people aged 60 to 90. Twenty-five volunteers will drink either the test formula or a plain carbohydrate drink on two separate days, and doctors will track st…

This study looks at how different amounts of clear liquids (like water or juice) affect stomach contents in teens aged 13-17 before an upper GI endoscopy. Participants are randomly assigned to drink 3, 5, 7, or 10 ml of clear fluid per kilogram of body weight two hours before the…

This study uses ultrasound imaging to measure how quickly the stomach empties after feeding in healthy newborns and infants. Researchers will watch the stomach shrink back to its starting size after babies drink clear liquids, breast milk, or formula. The goal is to learn normal …

This study is building a large database of 3000 people with gastroparesis, a condition that causes nausea, vomiting, and stomach pain. Researchers will follow patients over time to see how different treatments—like nerve stimulation, immunotherapy, or pyloric therapies—affect the…

This observational study is investigating whether heterotopic gastric mucosa (HGM), a patch of stomach-like tissue found in the upper esophagus, is associated with swallowing difficulties (dysphagia) and indigestion (dyspepsia). Researchers will compare symptoms and quality of li…

This study is looking at whether long-term blood sugar levels (HbA1c) affect how fast the stomach empties before surgery. Slow stomach emptying can increase the risk of stomach contents entering the lungs during anesthesia. Researchers will use ultrasound to measure stomach conte…

This study looks at whether ultrasound can reliably measure how much is in a child's stomach before surgery, which could help prevent rare but serious complications like breathing in stomach contents. About 60 children aged 2 to 18 will have stomach ultrasounds, and some will als…

This study is creating a registry of 250 people with symptoms of gastroparesis or functional dyspepsia, such as nausea, vomiting, and abdominal pain. Participants will fill out questionnaires, take a nutrient drink test, and have a gastric emptying scan. The goal is to collect da…

This study aims to find out if people with gastroparesis (stomach paralysis) have abnormalities in the pyloric sphincter, the valve between the stomach and small intestine. Researchers will use special imaging tools to measure how flexible and open this valve is. The study will e…

This study is creating a national registry of 216 children, teens, and young adults (ages 8-25) with gastroparesis or similar symptoms. Researchers will track how symptoms like nausea and stomach pain change over 48 weeks using questionnaires and stomach-emptying tests. The goal …

This study looks at whether eosinophilic gastritis, a rare stomach condition, causes problems with how the stomach moves food. Researchers will use a special scan after an oatmeal meal to check stomach emptying in 30 people. The goal is to better understand if these motility issu…

This observational study looks at how bariatric surgery changes cortisol metabolism and whether that contributes to reactive hypoglycemia (low blood sugar after meals). Researchers will measure cortisol levels during a meal test and check adrenal function in 100 people who had ga…

This study aims to develop a simple tool to predict whether a person's stomach will still have food or liquid in it before a sedated endoscopy. Having a full stomach during sedation raises the risk of serious complications like choking. Researchers will study 5,000 adults to iden…

This study looks at whether people taking GLP-1 or GIP medications (like Ozempic or Mounjaro) have more food left in their stomach after standard fasting before surgery. Researchers will use ultrasound to measure stomach volume in 150 adults who either fasted for 8 hours or had a…

This study looks at why people with diabetes develop gastroparesis, a condition where the stomach doesn't empty properly. Researchers will collect blood and stomach tissue samples from 50 participants to examine how certain molecules affect stomach muscle function. The goal is to…

This study tests whether a non-invasive device called Body Surface Gastric Mapping can predict which patients with gastroparesis will benefit from G-POEM surgery. Researchers will monitor 20 patients before and after the procedure using a sticky electrode patch on the stomach are…

This observational study aims to understand stomach electrical activity in children aged 8-25 with digestive issues like slow stomach emptying or chronic pain. Researchers will use a non-invasive device (BSGM) to record stomach signals for up to 4 hours and compare them to health…

This study looks at why some people develop delayed gastric emptying (stomach not emptying properly) after pancreatic surgery. Researchers will review medical records of 3500 patients who had pancreatic surgery to find risk factors, such as surgical method or feeding tube use. Th…

This study is following 2000 adults with functional digestive disorders like irritable bowel syndrome, dyspepsia, and constipation. Researchers will collect medical data and biological samples (biopsies, blood, urine, stool) during routine care. The goal is to find markers that c…

This study looks at why some babies born with esophageal atresia develop dumping syndrome, a condition causing dangerous blood sugar drops after feeding. Researchers will monitor 15 infants with continuous glucose and heart monitors and a stomach-emptying scan at 3 months old. Th…

This observational study measures the carbon footprint produced during upper GI endoscopy in 75 patients with either dyspepsia (diagnostic scope) or non-variceal upper GI bleeding (therapeutic scope). Researchers track emissions from when a patient enters the endoscopy room until…

This small pilot study aims to see if a new in-ear wearable device can comfortably and reliably measure blood flow changes in the head. Researchers will compare people who have low blood sugar after bariatric surgery to those who don't. The goal is to learn if this device can hel…

This study looks at whether people with a certain stomach lining condition (chronic atrophic gastritis) have different indigestion symptoms than those without it. Researchers will compare symptom patterns in about 315 adults who recently had an endoscopy. The goal is to better un…

This study uses a noninvasive device to stimulate a nerve in the ear and see how it changes brain and stomach activity. Researchers will use MRI scans to measure these effects in healthy adults and people with stomach discomfort. The goal is to better understand how the brain and…

This study looks at how quickly the stomach empties in women during early labor when they drink either water or a sports drink. It includes women with and without epidural pain relief. The goal is to understand digestion during labor, not to test a treatment.

This study looks at whether women with functional dyspepsia (a condition causing stomach pain and discomfort without a clear cause) have different body composition than healthy women. Researchers will use a simple, non-invasive test called bio-electrical impedance to measure fat …

This study looks at how gastric bypass and sleeve gastrectomy affect blood sugar control after eating. Researchers will give two drugs—Exendin-(9-39) and atropine—to understand the roles of hormones and nerves. The goal is to learn why some patients develop low blood sugar after …

This study looks at how a hormone called GLP-1 helps control blood sugar and weight loss after gastric bypass surgery. Researchers will give a drug that blocks GLP-1 to 80 people, including those who had surgery and healthy controls, to measure its effects. The goal is to underst…