Functional gastric disease

This study tests a new drug called MBX 1416 in 10 people who have low blood sugar episodes after weight loss surgery. Participants receive two injections of the drug, a low dose and a high dose, about two weeks apart. The goal is to see if the drug can raise the lowest blood suga…

This study tested a new robotic surgery technique that protects the vagus nerve during spleen removal and blood vessel disconnection in 60 cirrhosis patients with portal hypertension. The goal was to see if it reduces common side effects like diarrhea and delayed stomach emptying…

This study tested whether adding a traditional Chinese herbal formula (Banxiaxiexin decoction) to standard antibiotics can better treat H. pylori infection and related indigestion. 104 adults with both conditions took either the herbal combo or standard therapy for 14 days. The m…

This study tested whether transplanting specific stomach bacteria (probiotics) could relieve symptoms of functional dyspepsia, a common digestive disorder. 74 adults with indigestion but no H. pylori infection received either the probiotic or a placebo. The main goal was to see i…

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This study tested a drug called mizagliflozin in 15 people who had gastric bypass surgery and suffer from dangerously low blood sugar after eating. The goal was to see if the drug could reduce these episodes and improve safety. The trial is now complete, and results will help det…

This study tested a special capsule with a magnet inside that doctors can control from outside the body. The capsule takes pictures of the stomach to see how it moves and digests food. Researchers wanted to see if this device could help diagnose conditions like gastroparesis and …

This study tested a new, noninvasive technique called magnetogastrogram (MGG) to measure the stomach's electrical activity without radiation. Researchers studied 22 people, including those with diabetes, gastroparesis, and other stomach conditions, to see if the test can tell nor…

This study tests whether a mild electrical pulse to the ear (taVNS) can change how the brain and stomach interact in people with chronic indigestion or gastroparesis. Researchers will use brain scans and stomach electrical readings to see if the stimulation helps. The goal is to …

This study tests whether a chair-based yoga program is practical and acceptable for people with functional dyspepsia or gastroparesis—conditions that cause nausea, vomiting, and stomach pain. Ten adults will attend two one-hour yoga sessions and practice at home. Researchers will…

This study tested whether cognitive behavioral therapy (CBT) can reduce symptoms of gastroparesis, a condition where the stomach empties slowly, causing nausea, bloating, and pain. Twenty-seven adults with idiopathic gastroparesis received CBT sessions and were assessed before an…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested a new syrup, called Fibroin Syrup, to see if it is safe and can help reduce symptoms of gastroesophageal reflux disease (GERD), like heartburn and regurgitation. The study included 47 adults with non-erosive reflux disease (NERD) who had symptoms for at least 8 …

This study looked at 60 people with a common stomach condition called functional dyspepsia, which causes pain and fullness after meals. Participants were split into two groups: one followed standard advice (small meals, avoid fatty/spicy foods), and the other tried a low FODMAP d…

This study tested a new drug called naronapride in 328 adults with moderate to severe gastroparesis (stomach paralysis). Participants took either 10, 20, or 40 mg of the drug or a placebo daily for 12 weeks. The goal was to see if the drug could reduce symptoms like nausea, vomit…

This study tested if taking itopride once daily works as well as taking it three times a day for people with ongoing stomach discomfort (functional dyspepsia). Over 500 adults participated, and researchers measured symptom changes over 8 weeks. The goal was to see if a simpler do…

This study tested whether a device that sends small electrical pulses to the stomach can help children with severe, long-lasting nausea and vomiting. Thirty kids who hadn't gotten better with standard treatments took part. Each child had a temporary pacing lead placed through a t…

This study tested a drug called DLBS2411 in 106 adults with functional dyspepsia, a condition causing stomach pain and fullness without a clear cause. Participants took either the drug or a placebo twice daily for 4 weeks. The goal was to see if the drug improves quality of life …

This small study tested whether taking glutamine powder three times a day can reduce stomach symptoms and improve gut barrier health in people with functional dyspepsia (chronic indigestion without a clear cause). Twelve participants were randomly assigned to receive either gluta…

This study tested if listening to hypnotherapy audio files can help children and teens with stomach pain and bowel problems linked to stress. 32 participants used the audio treatment at home. The goal was to see if this approach is practical and effective, potentially offering a …

This study tested whether taking artemisia and green tea extracts for 8 weeks can improve stomach health in adults with functional dyspepsia (indigestion without a clear cause). 100 participants were randomly assigned to receive the extracts or a placebo. The main goal was to see…

This study tested an experimental drug called CIN-102 (deudomperidone) to see if it can reduce nausea, vomiting, and other stomach symptoms in adults with diabetic gastroparesis—a condition where the stomach empties too slowly. About 382 participants took either the drug or a pla…

This study tested a non-instrumental biofeedback technique to help people with irritable bowel syndrome or dyspepsia who experience visible abdominal bloating after meals. 41 participants were taught to control their abdominal and chest muscles using a video guide, then practiced…

This study tested whether a device that gently stimulates the vagus nerve through the ear could reduce delayed stomach emptying after a major pancreatic surgery (pancreaticoduodenectomy). 84 patients were randomly assigned to receive the stimulation during surgery or not. The goa…

This completed Phase 3 trial tested whether ENO Lime, a fruit salt powder, can quickly ease symptoms of indigestion, acidity, and nausea. Forty adults with recent symptoms took a single dose, and their discomfort was measured before and 15 minutes after. The study aimed to see if…

This study tested whether a liquid dietary supplement called Anvitra Gastric Suspension can reduce heartburn, regurgitation, and indigestion in people with GERD. Twenty-seven adults took the supplement three times daily for 14 days. Researchers measured symptom changes using a st…

This study tested a wearable device that delivers mild electrical pulses through the skin, similar to acupuncture, to help relieve stomach symptoms in people with diabetic gastroparesis. 41 participants used the device at either a treatment point or a sham point for 84 days. Rese…

This study followed 300 adults with functional dyspepsia (chronic stomach discomfort) who were taking standard medications like acid reducers or antidepressants. The goal was to see which factors—such as anxiety or sleep problems—might predict whether symptoms improve after 6 mon…

This completed study looked at how meals with different amounts and types of fat and carbohydrates affect digestion and blood sugar/fat levels in 12 healthy adults. Participants ate test meals and had blood samples taken over 5 hours. The goal was to understand how meal compositi…

This completed study looked at whether stomach emptying is slower during a heart attack, which could delay the absorption of crucial antiplatelet drugs. Researchers measured paracetamol levels in the blood every 15 minutes in 23 participants to track stomach emptying. The goal wa…

This study tested whether adding omentopexy — stitching the omentum to the stomach — during sleeve gastrectomy changes stomach shape and emptying. Thirty-six adults having weight-loss surgery were randomly assigned to get the extra stitch or not. Researchers measured stomach angl…

This study looked at 42 infants who had surgery for a rare birth defect called esophageal atresia type III. Researchers gave the babies a sugary drink to see how often they developed dumping syndrome, a condition causing rapid blood sugar changes. The goal was to find out how com…

This study looked at why many critically ill children develop gut problems like slow digestion and leaky gut. Researchers measured certain proteins linked to inflammation in 99 children to see if they cause these issues. The goal was to better understand the problem, not to test …

This completed study tested whether noninvasive brain stimulation can be personalized by measuring heart rate responses. Researchers mapped the scalp to find the best spot for stimulation in 34 healthy participants and people with depression, anxiety, and gut issues. They compare…

This study looked at 18 women who had sleeve gastrectomy surgery 2-3 years earlier. Researchers compared stomach emptying rates between those who lost a lot of weight (over 35% of total weight) and those who lost little (under 25%). They used MRI and a special scan to measure how…

This study looked at whether giving a carbohydrate drink (yogurt with honey) before elective abdominal surgery is safe and helpful for people with type 2 diabetes. 120 patients were split into three groups: non-diabetic controls, non-diabetic with the drink, and diabetic with the…

This study looked at 186 adults taking GLP-1 RA drugs (like Ozempic) who were scheduled for surgery. Researchers used ultrasound to measure stomach contents at different times after the last dose. The goal was to find out how long it takes for stomach emptying to return to normal…

This study looked at whether GLP-1 medications (used for diabetes and weight loss) increase the risk of having food or liquid in the stomach before surgery, even after the recommended fasting period. Researchers used a quick ultrasound to check stomach contents in 94 adults sched…

This completed Phase 4 trial at the Cleveland Clinic enrolled 69 adults with type 2 diabetes or obesity who take GLP-1 medications. Participants were randomly assigned to either continue or pause their GLP-1 drug before an upper endoscopy. The goal was to see if holding the medic…

This study looked at nearly 500 people with stomach and bowel problems to see if a low-FODMAP diet helps reduce symptoms. Researchers also checked for joint hypermobility (very flexible joints) and how the gut microbiome might be linked. The goal is to better understand who benef…

This study looked at whether giving a carbohydrate drink 2 hours before surgery is safe for people with well-controlled type 2 diabetes. 76 adults were split into two groups: one got the drink, the other fasted as usual. Researchers measured blood sugar and checked stomach conten…

This study tested whether dexmedetomidine, a sedative often used during surgery, changes how quickly the stomach empties in people having their gallbladder removed. Researchers used ultrasound to measure stomach volume in 80 patients before and after surgery. The goal was to see …

This study tested how two types of soluble fiber—fructooligosaccharide and partially hydrolyzed guar gum—affect how fast food leaves the stomach and moves through the intestines. Twenty-five healthy adults each tried both fibers and a placebo on separate days. The goal was to see…

This study used bedside ultrasound to see if people taking semaglutide (Ozempic, Wegovy) have more food or liquid in their stomachs before surgery, despite fasting. Researchers compared 88 adults on semaglutide to those not taking it. The goal was to help anesthesiologists decide…