Pause or pop? study tests if stopping GLP-1 drugs before endoscopy reduces stomach risks
NCT ID NCT06533527
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed Phase 4 trial at the Cleveland Clinic enrolled 69 adults with type 2 diabetes or obesity who take GLP-1 medications. Participants were randomly assigned to either continue or pause their GLP-1 drug before an upper endoscopy. The goal was to see if holding the medication reduces the amount of food or liquid left in the stomach, which can interfere with the procedure or cause dangerous aspiration. The study did not test a new treatment but aimed to improve safety guidelines for common procedures.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
GLP-1 medications (e.g., tirzepatide, semaglutide, liraglutide, dulaglutide)
What this could lead to
If successful, this could lead to updated guidelines on whether to pause GLP-1 drugs before endoscopy to reduce stomach contents and aspiration risk.
What could go wrong
This is a small, single-center trial with only 69 participants. Results may not apply to all patients or settings, and the study does not test a new treatment.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cleveland Clinic
Weston, Florida, 33331, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States