Functional gastric disease

This pilot trial will test a disposable endoscope in 40 adults undergoing POEM procedures for achalasia or gastroparesis. The goal is to see if the single-use scope works as well as standard reusable scopes, potentially reducing infection risk. All participants receive standard c…

This study tests whether domperidone, a drug that speeds up stomach emptying, can help people with type 1 diabetes keep their blood sugar in a healthy range. About 70 adults with type 1 diabetes who have slow stomach emptying but no digestive symptoms will take either domperidone…

This study will test whether standard treatment to eliminate H. pylori bacteria can improve ongoing stomach and gut symptoms in 100 adults. Participants will receive antibiotics and acid-reducing medication, and their symptoms will be tracked using a questionnaire. The goal is to…

This study tests whether a dietary supplement made from ginger and perilla (Dispepril®) can improve stomach symptoms in people with functional dyspepsia, a condition causing fullness, bloating, and pain after eating. 400 adults will be randomly assigned to take the supplement alo…

This study looks at whether adding Cognitive Behavioral Therapy (CBT) to standard medical care can reduce stomach symptoms in adults with functional dyspepsia, a condition causing pain or discomfort after eating. About 90 adults aged 18-65 will be randomly assigned to receive eit…

This study tests whether adding digestive enzymes to standard treatment helps people with functional dyspepsia, a condition causing stomach fullness, pain, and burning. 120 adults will take either enzymes plus standard care or standard care alone for 4 weeks. Researchers will tra…

This study tests whether Anakinra, a drug that reduces inflammation, can prevent dangerous drops in blood sugar after meals in a patient who had his stomach removed. The 52-year-old man also has kidney failure and needs dialysis. Over 10 weeks, he will receive either Anakinra or …

This study looks at whether changing the settings on an already-implanted stomach pacemaker (Enterra™) can reduce chronic abdominal pain in people with gastroparesis, a condition where the stomach empties slowly. Researchers will randomly assign 150 adults to one of three stimula…

This study tests if a gentle electrical stimulation on the outer ear can activate the vagus nerve and reduce nausea, vomiting, and stomach discomfort in people with diabetes and gastroparesis. Sixty adults with both conditions will receive the treatment and report symptom changes…

This study tests whether electroacupuncture (mild electrical pulses through thin needles) can help patients whose stomachs stop working properly after surgery for digestive tract tumors. Seventy-six adults who had such surgery and developed gastroparesis (stomach paralysis) will …

This study tests whether electroacupuncture—acupuncture with mild electrical pulses—can safely ease symptoms of functional dyspepsia, a condition causing stomach fullness or pain after eating. About 105 adults aged 18 to 80 will be split into groups receiving needles on the abdom…

This study tests whether acotiamide works better than itopride for people with functional dyspepsia, a condition causing fullness, pain, or burning after meals. About 368 adults will take one of the two pills three times daily for 4 weeks and track their symptoms. The goal is to …

This study tests if inflating a small balloon in the stomach during surgery can prevent nausea, vomiting, and slow stomach emptying after pancreatic tumor removal. About 70 adults will be randomly assigned to get the balloon procedure or standard surgery. Researchers will track r…

This study will test whether giving dexamethasone, dexmedetomidine, or both right after gallbladder surgery helps the gut start working again sooner. 160 adults having laparoscopic gallbladder removal will be randomly assigned to one of four groups, including a placebo. The main …

This study looks at whether a multi-strain probiotic capsule can reduce common digestive issues like bloating, fullness, and stomach pain in adults with functional dyspepsia. Sixty participants will take either the probiotic or a placebo daily for 60 days and report their symptom…

This study tests whether a mobile app that plays guided imagery sessions can help reduce chronic abdominal pain in children aged 7 to 12. Participants listen to 10-15 minute audio sessions five days a week for eight weeks, alongside their usual care. The goal is to see if this ap…

This study tests whether a herbal medicine called STW 5-II can reduce inflammation in the gut lining and ease symptoms like stomach pain, bloating, and fullness after eating in people with functional dyspepsia. About 100 adults will take either the herbal remedy or a placebo for …

This study compares two drugs, acotiamide and itopride, to see which one better relieves symptoms like fullness, bloating, and early fullness after meals in people with postprandial distress syndrome. The trial will include 152 adults aged 18-70 who have been diagnosed using stan…

This study follows 200 people with functional dyspepsia, a common stomach disorder causing fullness and pain after meals. Participants will take itopride as part of their normal care. Researchers will track symptom changes over 16 weeks to see if the drug helps in real-world sett…

This study tests a new one-click autofocus system for magnifying endoscopy, which uses computer vision to automatically focus the camera during stomach exams. Researchers will compare it to the standard manual focus method in 93 patients with stomach diseases. The goal is to see …

This study will collect data from 10,000 people undergoing upper endoscopy to build an AI model that predicts the risk of developing stomach or esophageal cancer. Researchers will combine information from endoscopy images, tissue samples, genetics, and gut bacteria. Participants …

This study looks at how emotional state influences the course of functional dyspepsia and irritable bowel syndrome in 150 adults. Participants will fill out questionnaires about their quality of life, mood, and anxiety at the start and after treatment. The goal is to better under…

This study looks at whether combining a blood test for H. pylori bacteria with a painless stomach ultrasound can predict serious complications from peptic ulcers, like bleeding or a hole in the stomach. Researchers will study 230 adults with stomach symptoms to see if these non-i…

This study compares two ways to reconnect the digestive tract after pancreatic cancer surgery (Whipple procedure). The goal is to see which method reduces delayed stomach emptying, a common complication. About 124 adults having this surgery will be randomly assigned to one of the…

This study looks at whether stopping GLP-1 receptor agonists (like Ozempic or Wegovy) for two weeks before an upper endoscopy lowers the chance of food staying in the stomach. Researchers will review medical records from over 16,000 people to compare those who paused the drug wit…

This study will follow 460 diabetes patients who take semaglutide to see if those with nerve damage (neuropathy) are more likely to develop stomach retention, where food stays in the stomach too long. Participants will have a stomach exam to check for retained food or liquid. The…

This study will compare two groups of people having an endoscopy: those who stopped taking semaglutide for one week beforehand, and those who never took it. The goal is to see if stopping the drug reduces leftover food or liquid in the stomach, which can make the procedure safer …

This study will look at 150 infants and children aged 1 month to 4 years who are admitted to a hospital gastroenterology unit with a gastrointestinal disease. The goal is to find out how common electrolyte disturbances (like low sodium or potassium) are in these children. By meas…